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Product Name: Bis(2-Chloroethyl)Methylamine
Synonyms: HN2, Nitrogen Mustard, Mechlorethamine
Chemical Family: Alkylating agent
Recommended Use: Chemotherapy reagent, laboratory chemical
Supplier: Consult chemical manufacturer for details
Emergency Phone: Refer to institutional or regional chemical safety lines
CAS Number: 51-75-2
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) – Category 2; Skin Corrosion/Irritation – Category 1; Serious Eye Damage/Irritation – Category 1; Carcinogenicity – Category 1A; Specific Target Organ Toxicity (Repeated Exposure) – Category 2
Pictograms: Skull and Crossbones, Corrosive, Health Hazard
Signal Word: Danger
Hazard Statements: Fatal if inhaled or swallowed, causes severe skin burns and eye damage, may cause cancer, causes damage to organs
Precautionary Statements: Avoid all contact, use appropriate protective gear, do not breathe dust or vapor, wash thoroughly after handling
Chemical Name: Bis(2-Chloroethyl)Methylamine
CAS Number: 51-75-2
Concentration: >98% (pure substance)
Inhalation: Move person to fresh air, keep airway clear, provide oxygen or CPR if needed, get immediate medical assistance
Skin Contact: Remove contaminated clothing and rinse skin with copious amounts of water for at least 20 minutes, seek urgent medical advice
Eye Contact: Flush cautiously with water for at least 20 minutes, lift eyelids occasionally, immediate medical evaluation is vital
Ingestion: Never give anything by mouth to an unconscious person, rinse mouth, do not induce vomiting, immediate medical attention is required
Most Important Symptoms: Severe irritation and blistering of skin and eyes, respiratory distress, burns, delayed onset of symptoms possible
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Straight streams of water
Special Hazards: Decomposition generates toxic gases including hydrogen chloride, nitrogen oxides
Protective Equipment: Full-body chemical protective suit, self-contained breathing apparatus
Instructions for Fire Fighters: Approach from upwind, cool containers, control runoff, do not breathe fumes
Personal Precautions: Evacuate area, limit access, ventilate space, wear appropriate chemical protective equipment
Environmental Precautions: Prevent chemical from entering sewers, waterways, or soil
Cleaning Methods: Absorb with inert material (sand, earth, vermiculite), collect in sealed containers, thoroughly wash contaminated surfaces with 5% sodium thiosulfate or sodium bisulfite solution, bag all cleanup materials for safe disposal
Handling: Work in chemical fume hood, avoid direct contact, use only with protective equipment, practice spill and exposure prevention, always keep containers tightly closed
Storage: Store in cool, dry, well-ventilated, flameproof area, segregate from incompatible chemicals (acids, bases, oxidizers), protect from moisture and light, use corrosion resistant containers with clear labeling, lock up area if permitted
Control Parameters: Occupational exposure limit not established, minimize exposure as much as possible
Engineering Controls: Certified chemical fume hood, eyewash stations, emergency showers in work area, maintain negative room pressure
Personal Protective Equipment: Impermeable gloves, full-body suit, chemical-resistant boots, face shield with tight fitting goggles, respiratory protection (PAPR or equivalent) for airborne concentrations or spill scenarios
Appearance: Colorless to pale yellow oily liquid
Odor: Fishy, irritating odor
Melting Point: –23°C
Boiling Point: 217°C
Flammability: Not highly flammable, but combustible
Explosive Properties: Not explosive
Vapor Pressure: 0.1 mmHg at 20°C
Solubility: Soluble in water and most organic solvents
pH: Not relevant for pure material
Density: 1.09 g/cm³ at 20°C
Partition Coefficient (log Kow): Data limited; moderate mobility expected
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts violently with strong acids, bases, oxidizing agents, moisture
Hazardous Reactions: May produce toxic fumes of nitrogen oxides and hydrogen chloride under fire or decomposition
Conditions to Avoid: Heat, light, moisture, incompatibles
Decomposition Products: Hydrogen chloride, methylamine, nitrogen oxides, chloroacetaldehyde
Acute Toxicity: Extremely toxic by inhalation, ingestion, dermal contact; LD50 (oral, rat): approx. 2 mg/kg
Chronic Effects: Proven carcinogen (IARC Group 1), mutagen, reproductive toxin
Routes of Exposure: Skin, eyes, inhalation, ingestion
Symptoms: Severe blistering, necrosis, respiratory distress, eye damage; systemic organ toxicity possible
Target Organs: Skin, eyes, respiratory tract, bone marrow, immune system
Sensitization: Likely to cause both skin and respiratory sensitization
Ecotoxicity: Highly toxic to aquatic life, extremely hazardous to soil microorganisms
Persistence and Degradability: Degrades slowly in environment, breakdown accelerated by water and sunlight
Bioaccumulative Potential: Low to moderate; readily distributes in environment
Mobility in Soil: Highly mobile in moist soils, risk of groundwater contamination
Other Adverse Effects: Toxic to birds and mammals, even at low concentration; strict control of releases required
Waste Treatment Methods: Treat as hazardous chemical waste, destroy by controlled incineration at high temperature (<1100°C) with scrubbers
Container Disposal: Triple rinse, destroy by puncture and disposal in accordance with local, regional, national guidelines
Special Precautions: Do not dump into sewers, water systems, or on soil, consult local hazardous waste authorities for proper treatment
UN Number: 2810
UN Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (Bis(2-Chloroethyl)Methylamine)
Transport Hazard Class: 6.1 (Toxic substances)
Packaging Group: I (high danger)
Marine Pollutant: Yes
Labeling Requirements: Toxic, Marine Pollutant, Keep Away from Food
Registry Listings: OSHA: Regulated, IARC: Group 1 Carcinogen, NIOSH: Special handling, EPA: Extremely Hazardous Substance
TSCA: Listed, subject to reporting and handling restrictions
SARA Title III: Section 302 (Extremely Hazardous), Section 313 (Reportable Release)
RCRA: Classified as hazardous waste
REACH Status: Not permitted for general use in the EU; only for research with restriction and notification
Workplace Controls: Strict handling, monitoring, and reporting requirements apply in most regulated regions
