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Product Name: Bis(1-Methylethyl) Fluorophosphate
CAS Number: 107-49-3
Synonyms: O,O-Diisopropyl fluorophosphate, DFP
Recommended Uses: Commonly used in biochemical research as a serine protease inhibitor and in laboratory studies; industrial applications remain limited due to high toxicity.
Supplier: Manufacturer’s contact details and emergency telephone number usually found on the product label for immediate queries.
Classification: Acute Toxicity (Oral, Dermal, Inhalation – Category 2), Serious Eye Damage (Category 1), Skin Irritation (Category 2), Specific Target Organ Toxicity (Single Exposure – Category 2).
Signal Word: Danger
Hazard Statements: Fatal if swallowed, in contact with skin, or if inhaled. Causes severe eye damage and skin irritation. May cause respiratory irritation, muscle twitching, and convulsions. Individuals with medical conditions like epilepsy or asthma face greater risk.
Pictograms: Skull and crossbones, exclamation mark, corrosion symbol.
Precautionary Statements: Never breathe dust, vapors, or spray. Wash hands thoroughly after handling, use personal protective clothing. Seek medical attention promptly in the event of exposure.
Chemical Name: Bis(1-Methylethyl) Fluorophosphate
Chemical Formula: C6H14FO3P
Purity: >98% (typical for research-grade material)
Impurities: May contain trace amounts of related phosphates or decomposition products depending on storage and transport conditions.
Other Components: No significant non-hazardous components medically relevant in this compound.
Inhalation: Move affected individual to fresh air immediately. Remove tight clothing and keep body warm. Seek urgent medical help. Artificial respiration may be required if breathing ceases.
Skin Contact: Remove contaminated clothing. Wash skin with plenty of water and soap for at least fifteen minutes. Get immediate medical assistance.
Eye Contact: Rinse eyes directly with plenty of water for at least fifteen minutes, holding eyelids open. Immediate medical attention is crucial.
Ingestion: Rinse mouth. Do not induce vomiting. If person is conscious, offer water in small sips. Medical supervision essential – urgent hospital care is needed.
Important Symptoms: Tremors, muscular twitching, blurred vision, difficulty breathing, convulsions, rapid loss of consciousness.
Medical Attention: Atropine sulfate and pralidoxime chloride are recognized antidotes, available only in emergency medicine settings.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder or carbon dioxide for small fires.
Specific Hazards: Releases toxic gases such as phosphorus oxides, hydrogen fluoride and carbon monoxide during combustion. Heat causes expansion or decomposition which can lead to violent rupture of containers.
Special Protective Equipment: Firefighters wear full protective gear with self-contained breathing apparatus. Avoid inhaling vapors or fumes, use water spray to cool unopened containers.
Other Information: Runoffs from firefighting water may be highly toxic, must be contained and disposed of according to strict protocols.
Personal Precautions: Wear protective equipment: gloves, lab coat, eye protection, and respirators suitable for organophosphates. Ensure adequate ventilation or evacuate area.
Environmental Precautions: Avoid entry into sewers, soil or water bodies. Inform relevant authorities immediately.
Spill Procedures: Absorb spills with inert material such as sand or inert absorbent. Scoop up and place into tightly sealed chemical waste container for proper disposal. Wash affected area thoroughly with alkaline detergent and water. Ventilate area after clean-up.
Handling: Perform all procedures in a chemical fume hood. Keep containers tightly closed. Do not breathe vapors or allow contact with clothing, skin or eyes. No eating, drinking, or smoking in area.
Storage: Store under inert gas (nitrogen or argon), in tightly sealed containers, away from light and incompatible materials like strong oxidizing agents. Keep in a cool, well-ventilated and locked area. Clearly label containers and restrict access to trained personnel.
Recommended Storage Temperature: 2–8°C, away from moisture or heat sources, in a corrosion-resistant, poison-labeled cabinet.
Exposure Limits: No specific workplace exposure limit available; compound considered highly toxic by inhalation, ingestion, and skin absorption.
Engineering Controls: Use fume hoods, eyewash stations, and emergency safety showers in work area.
Personal Protective Equipment (PPE): Wear chemical-resistant gloves (butyl rubber or nitrile), safety goggles, laboratory apron or suit, face shield if risk of splash present, and NIOSH-approved respiratory protection where fume concentrations may exist.
Hygiene Measures: Wash thoroughly after handling, use protective creams on exposed skin, never touch face during work.
Appearance: Colorless to pale yellow liquid
Odor: Slightly fruity, faint odor
Melting Point: -65°C
Boiling Point: 69–70°C at 19 mm Hg
Flash Point: Not determined precisely, but considered flammable at elevated temperatures.
Solubility: Moderately soluble in water, soluble in alcohol, ether, and most organic solvents.
Vapor Pressure: 0.41 mmHg at 20°C
Density: 1.077 g/cm³ at 20°C
pH: Not applicable (organic phosphate)
Chemical Stability: Stable under recommended storage conditions (inert atmosphere, cold, dry).
Reactivity: Reacts violently with strong oxidizers, acids, and alkalis. Avoid moisture.
Decomposition Products: Phosphorus oxides, carbon monoxide, hydrogen fluoride, and other hazardous gases form during high heat or fire.
Polymerization: No hazardous polymerization expected under normal use.
Main Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: Extremely toxic. Oral LD50 (rat) 1 mg/kg, Dermal LD50 (rabbit) 3 mg/kg; minimal exposure can be fatal.
Chronic Effects: Repeated or prolonged exposure may cause delayed neurological symptoms including peripheral neuropathy, muscle weakness, and memory disturbances.
Symptoms of Exposure: Salivation, sweating, nausea, headache, blurred vision, breathing difficulty, convulsions, loss of consciousness, and potentially death.
Other Effects: Severe irritant to eyes and skin; inhalation of vapor rapidly produces poisoning symptoms. No known carcinogenic, mutagenic, or reproductive risk from currently available studies.
Ecotoxicity: Very toxic to aquatic life due to high acute toxicity and persistence in water. Fish, invertebrates and algae show marked sensitivity and are at risk from even minor contamination incidents.
Persistence and Degradability: Degrades slowly in water; long-term environmental hazards possible.
Bioaccumulative Potential: Not well documented, but high acute toxicity limits chances for bioaccumulation in food chains.
Mobility in Soil: May leach and contaminate groundwater under improper disposal or accidental spill conditions.
Other Information: High risk for environmental release; spills cause ecosystem disruption, so responsible use and disposal matter.
Disposal Methods: Incinerate at approved facility equipped to process hazardous chemical waste. Local, regional, and national hazardous waste management guidelines govern procedures.
Contaminated Packaging: Triple-rinse empty containers, then puncture and destroy to prevent reuse. Treat rinsate as hazardous waste.
Improper Disposal Risks: Entry into the environment or drainage systems may harm living organisms and pollute water sources.
UN Number: UN 3276
Proper Shipping Name: Organophosphorus compound, toxic, liquid, n.o.s. (Diisopropyl fluorophosphate)
Transport Hazard Class: Class 6.1 (Toxic substances)
Packing Group: I (severe risk)
Labels: Toxic, environmental hazard symbol required.
Transport Precautions: Keep in secure, leak-proof containers. Follow all regulations for hazardous materials in air, rail, road, or sea transit.
TSCA Status (US): Subject to reporting and regulation under Toxic Substances Control Act.
OSHA Status: Extremely Hazardous Substance; use only in compliance with regulatory standards for toxic chemicals.
EU Classification: EC Labeling required; listed as Toxic (T+); Risk phrases R26/27/28, S1/2/36/39/45.
SARA Title III: Listed as extremely hazardous.
Other Regulations: Listed by international conventions restricting toxic organophosphate use; only for research or restricted technical applications.
