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Product Name: Bezafibrate
Synonyms: Benzafibrate, Bezalip
Chemical Name: 2-[4-(2-chlorobenzamido)phenoxy]-2-methylpropanoic acid
CAS Number: 41859-67-0
Recommended Use: Pharmaceutical intermediate, laboratory research
Manufacturer/Supplier: Pharmaceutical and chemical supply companies
Emergency Contact: Local poison control center or national emergency number
Classification: Not classified as hazardous under GHS for normal laboratory use, but can be an irritant
Signal Word: None
Hazard Statements: May cause slight irritation to the skin, respiratory tract, and eyes
Precautionary Statements: Handle using standard laboratory precautions, avoid inhalation and prolonged contact with skin or eyes
Symptoms of Exposure: Irritation, redness, sneezing, coughing, nausea if swallowed
Chemical Identity: Bezafibrate
Purity: ≥ 98% (depending on supplier)
Common Impurities: Related substances from synthesis, trace solvents
Molecular Formula: C19H20ClNO4
Molecular Weight: 361.8 g/mol
Inhalation: Remove person to fresh air, provide oxygen if needed, seek medical attention if symptoms persist
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing
Eye Contact: Rinse immediately with plenty of water, keep eyelids apart, seek medical attention if irritation continues
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice
Most Important Symptoms: Eye and skin irritation, coughing, nausea
Extinguishing Media: Use carbon dioxide, dry chemical powder, or appropriate foam
Special Hazards: Emits toxic fumes under fire conditions, including hydrogen chloride and nitrogen oxides
Protective Equipment: Firefighters should wear full protective clothing and self-contained breathing apparatus
Other Advice: Move containers from fire area if safe, cool with water spray to prevent explosion
Personal Precautions: Use personal protective equipment, ventilate area
Environmental Precautions: Prevent entry into waterways, drains, or soil
Containment and Cleanup: Sweep up and place in suitable closed container, avoid raising dust, clean area thoroughly with water and detergent
Handling: Handle in well-ventilated area, avoid dust generation, avoid contact with skin and eyes
Storage: Keep container tightly closed in dry, cool, well-ventilated place, protect from moisture and incompatible substances
Incompatible Materials: Strong oxidizing agents, strong bases
Engineering Controls: Use chemical fume hood, provide adequate ventilation
Eye Protection: Safety goggles
Skin Protection: Lab coat, gloves (nitrile recommended)
Respiratory Protection: Use respirator if dust is generated above permissible limits
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not available
Melting Point: 187–190°C
Boiling Point: Not available
Flash Point: Not available
Solubility: Slightly soluble in water, soluble in ethanol, methanol, chloroform, DMSO
Vapor Pressure: Not available
Partition Coefficient: logP ~3
Decomposition Temperature: Not established
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Excessive heat, moisture, incompatible materials
Materials to Avoid: Strong oxidizers, strong acids or bases
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon oxides
Polymerization: Will not occur under normal handling
Acute Toxicity: Oral LD50 in rats >2000 mg/kg (low toxicity)
Chronic Exposure: Long-term health effects not fully studied, but may cause organ changes at high doses in animal studies
Skin Irritation: Mild irritant
Eye Irritation: Mild irritant
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity: Tests indicate low risk in standard bacterial assays
Reproductive Toxicity: No significant effects observed in animal studies at therapeutic doses
Inhalation Risks: Data not available, minimize exposure
Ecotoxicity: Data limited, low acute aquatic toxicity expected
Persistance and Degradability: May not be readily biodegradable in environment, expected to have moderate persistence
Bioaccumulative Potential: Not expected to bioaccumulate significantly
Mobility in Soil: Expected to have low mobility due to low water solubility
Other Adverse Effects: Avoid release to larger water bodies and soil to reduce environmental impact
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations
Contaminated Packaging: Treat as hazardous chemical waste, rinse before recycling or dispose as hazardous container
Incineration: Use controlled incineration facility with proper emission control
Other Disposal Advice: Do not release to environment, avoid landfill when possible
UN Number: Not assigned
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not regulated
Packing Group: Not required
Environmental Hazards: None identified
Special Precautions: Avoid physical damage and moisture during transport
International Inventories: Listed in many chemical inventories as a pharmaceutical active ingredient
OSHA Status: Not hazardous
TSCA: Not listed
SARA Title III: Not subject to specific reporting
WHMIS Classification (Canada): Not controlled
Other Regulations: Subject to regulations applying to pharmaceuticals and laboratory chemicals, follow country-specific requirements
