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Product Name: Betamethasone Sodium Phosphate
Chemical Name: Betamethasone 21-phosphate disodium salt
CAS Number: 151-73-5
Recommended Uses: Active pharmaceutical ingredient commonly used in anti-inflammatory medications
Supplier/Manufacturer: Pharmaceutical producer or distributor with an accurate manufacturer contact available on packaging
Emergency Contact Number: 24-hour local poison control center or relevant emergency hotline
Classification: Not classified as acutely toxic but may cause health problems with prolonged exposure
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Hazards: Respiratory or skin sensitization possible; possible reproductive toxicity with chronic usage; high doses may suppress immune function
Pictograms: Exclamation mark (irritant), Health hazard, Environmental hazard
Signal Word: Warning
Hazard Statements: May cause allergic reaction; possible harm to organs through prolonged or repeated exposure; toxic to aquatic organisms
Precautionary Statements: Avoid inhalation, use protective clothing, avoid release to environment
Chemical Name: Betamethasone Sodium Phosphate
Concentration: 98-102% (as active ingredient)
Impurities: Trace organic solvents, minor excipients from synthesis and purification
Other Ingredients: Water of crystallization, sodium ions
Inhalation: Remove person to fresh air, keep warm and quiet, seek medical attention for symptoms
Skin Contact: Wash exposed area with soap and water, remove contaminated clothing, seek medical advice if irritation occurs
Eye Contact: Rinse immediately with plenty of running water for at least 15 minutes, seek medical attention if redness or irritation persists
Ingestion: Rinse mouth, do not induce vomiting without medical advice, seek immediate physician attention
Medical Notes: Possible risk to immunosuppressed and pregnant patients; treat symptomatically; provide supportive treatment for respiratory distress
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Extinguishing Media: Strong water jets may cause powder dispersion
Specific Hazards: Decomposition can release toxic fumes such as oxides of phosphorus, carbon monoxide, sodium oxides
Protective Equipment: Self-contained breathing apparatus, full protective gear
Advice for Firefighters: Move containers from fire area if safe, avoid inhaling combustion products, cool exposed containers with water spray
Personal Precautions: Avoid contact with skin and eyes, ensure proper ventilation, wear appropriate PPE (gloves, mask, goggles)
Environmental Precautions: Prevent further leakage or spillage, contain run-off, do not allow entry into drains or surface water
Methods for Cleaning Up: Sweep or scoop spilled product into suitable container for disposal, clean area with damp cloth or vacuum with HEPA filter, wash contaminated surfaces thoroughly
Emergency Procedures: Evacuate non-essential personnel and restrict access until clean-up completes
Handling: Use in a well-ventilated area, avoid generating dust, avoid prolonged or repeated contact with skin or eyes, wash hands after use
Storage: Store in a tightly sealed container, in a cool, dry, well-ventilated area, away from incompatible materials including strong oxidizers and acids
Incompatibilities: Moisture, light, strong acids, strong bases, and oxidizing agents
Special Requirements: Store at recommended temperature range, protect from light and humidity, keep away from food and drink
Exposure Limits: No exposure limits established specifically for this chemical
Engineering Controls: Laboratory fume hood or other effective local exhaust ventilation
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, lab coat, NIOSH-approved respirator for dust
Environmental Controls: Prevent contamination of air, water, soil; use closed systems where possible
Appearance: White or almost white crystalline powder
Odor: Odorless
Molecular Formula: C22H28FNa2O8P
Molecular Weight: 516.39 g/mol
Melting Point: 186-190°C
Solubility: Freely soluble in water; practically insoluble in most organic solvents
pH (1% solution): 7.0–8.5
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible at room temperature
Flammability: Not flammable under normal conditions
Partition Coefficient: log P (octanol/water): very low, indicating high aqueous solubility
Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizing agents; hydrolysis possible in presence of water/moisture
Decomposition Products: Toxic gases including phosphorus oxides, carbon dioxide, carbon monoxide, sodium oxides
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity: Oral LD50 values not firmly established; similar corticosteroids show moderate acute toxicity in animals
Chronic Toxicity: Prolonged exposure may lead to metabolic, endocrine, and immunological effects including adrenal suppression and hyperglycemia
Routes of Exposure: Inhalation, skin, ingestion, eyes
Symptoms: Coughing, throat irritation, headache, skin irritation, nausea depending on route
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Reproductive Toxicity: Animal studies and human case reports indicate risk of teratogenicity and reproductive toxicity with excessive systemic exposure
Other Effects: Allergic skin reactions possible; prolonged or repeated exposure can alter immune response
Aquatic Toxicity: Toxic to aquatic organisms even at low concentrations, risk of long-term adverse effects on aquatic environments
Persistence and Degradability: Limited biodegradation; persists in water and soil for extended periods
Mobility in Soil: High water solubility increases risk of groundwater contamination if released unchecked
Bioaccumulative Potential: Low log P value suggests minimal bioaccumulation, although persistence in the environment remains a concern
Waste Disposal: Handle as pharmaceutical waste; incineration recommended under controlled conditions at licensed facilities
Container Disposal: Rinse thoroughly, render unusable, dispose of according to local regulatory requirements
Precautions: Prevent leaching into soil or water; never dispose with regular solid or liquid waste streams
Regulatory Requirements: Comply with local, regional, and national regulations for disposal of hazardous pharmaceuticals
UN Number: Not classified as hazardous for transport by most regulatory agencies
Proper Shipping Name: Pharmaceutical compound, non-restricted
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions: Avoid direct sun exposure, shocks, and excess moisture during transport; use original packaging and keep sealed
OSHA Designation: Not listed as a hazardous substance
EPA: Drug not subject to RCRA hazardous waste classification, local rules may apply
Canada WHMIS: Not controlled
European Union: Listed in EINECS/ELINCS; meets REACH obligations for pharmaceutical substances
Other Information: All users must follow applicable workplace safety guidelines and good laboratory practices at all times
