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Product Name: Betamethasone Valerate
Chemical Family: Synthetic corticosteroid
CAS Number: 2152-44-5
Synonyms: Betnovate, Betamethasone 17-Valerate
Recommended Use: Topical pharmaceutical ingredient for anti-inflammatory and anti-pruritic purposes
Manufacturer Information: Provided by licensed pharmaceutical suppliers, contact details available on request
Emergency Telephone Number: National or regional poison control centers, local medics
GHS Classification: Not classified as hazardous under GHS, but it can impact skin, eyes, respiratory tract and cause hormone-related effects
Main Hazards: Skin absorption, inhalation of dust, possible allergy, adrenal suppression after prolonged exposure
Label Elements: Avoid unnecessary contact, use in well-ventilated area, keep out of reach of children
Precautionary Statements: Wear suitable gloves, avoid breathing dust or powder, wash skin after handling
Emergency Overview: White or off-white powder, may cause irritation, repeated exposure may harm organs by endocrine disruption
Active Ingredient: Betamethasone Valerate 99%
Molecular Formula: C27H37FO6
Molecular Weight: 476.57 g/mol
Impurities: Less than 1%, trace analogs or derivatives
Other Additives: None in pure form, pharmaceutical preparations may include vehicle excipients
Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes, seek medical assistance if irritation persists
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, consult physician for persistent effects
Inhalation: Move to fresh air, keep at rest, assist breathing if necessary, seek medical attention if symptoms develop
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice
Most Important Symptoms & Effects: Redness, rash, headache, nausea, risk of hormonal effects with significant exposure
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, fluorine-containing compounds may form
Special Protective Equipment: Wear self-contained breathing apparatus, chemical protective clothing
Fire and Explosion Hazards: May emit toxic fumes under fire conditions, dust may present a mild explosion risk in rare, extreme cases
Personal Protection: Use approved respirator, chemical-resistant gloves, goggles, protective clothing
Environmental Precautions: Prevent release into sewage, drains, and watercourses, avoid contamination of natural habitat
Clean-Up Methods: Sweep up without generating dust, place in tightly sealed, labeled containers for disposal, ventilate area
Decontamination: Wash affected area with water and detergent, dispose spills according to local regulations
Safe Handling Practices: Handle in well-ventilated area, avoid contact with skin, eyes, and clothing, avoid inhalation of powder
Storage Conditions: Store at 20–25°C, protect from moisture and light, use airtight containers
Incompatibilities: Avoid storage with strong oxidizing agents and acids
Technical Measures: Implement tools and engineering controls to prevent aerosol formation
Control Parameters: No established occupational exposure limits; minimize exposure as a precaution
Engineering Controls: Local exhaust ventilation, sealed handling systems
Personal Protective Equipment (PPE): Nitrile gloves, chemical safety goggles, lab coat, particulate respirator (if ventilation is inadequate)
Hygiene Measures: Wash hands after handling, avoid eating or drinking in the work area, keep contaminated clothing away from clean zones
Appearance: White to creamy-white crystalline powder
Odor: Odorless
Melting Point: 196–200°C
Boiling Point: Not readily available, decomposes
Solubility: Practically insoluble in water, soluble in acetone, ethanol, methanol, chloroform
pH: Neutral to slightly basic (varies with solvent)
Vapor Pressure: Negligible
Density: Approximately 1.17 g/cm³
Partition Coefficient (Log Pow): 3–4 (estimate, enhances dermal absorption)
Chemical Stability: Stable under standard conditions, sensitive to strong light, oxidizers
Hazardous Reactions: No dangerous reactions if used as directed
Materials to Avoid: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition: Releases CO, CO2, fluorinated gases in a fire
Polymerization: Not known to occur
Acute Toxicity: LD50 not precisely known, low acute oral toxicity in mammals, occupational exposure limits unestablished
Chronic Effects: Endocrine disruption after repeated exposure, skin thinning, immunosuppression in long-term or large doses
Routes of Exposure: Skin, respiratory tract, eyes
Immediate Symptoms: Itching, irritation, headache, dizziness
Long-term Effects: Risk of cortisol suppression, reversible skin or systemic steroid effects, reproductive toxicity deemed unlikely at normal exposure levels
Carcinogenicity: Not classified as a carcinogen by IARC, OSHA, ACGIH, NTP
Ecotoxicity: No detailed data available but as a steroid, toxic to aquatic organisms at high concentrations
Mobility: Low mobility in soil, may persist in the environment
Persistence and Degradability: Not readily biodegradable, potential for environmental accumulation
Bioaccumulation: Possible, steroid compounds can build up in aquatic food chains
Other Adverse Effects: Hormone active substances may disrupt local ecologies, avoid waterway contamination
Product Disposal: Incinerate in an approved facility or dispose according to pharmaceutical waste protocols
Contaminated Packaging: Triple rinse containers, treat as hazardous waste
Waste Code: Refer to local, national, and regional waste management regulations
Precautions: Do not allow entry into ground water, surface water, or soil
UN Number: Not regulated for transport as dangerous goods
Proper Shipping Name: Not subject to ADR/RID, ICAO/IATA, IMDG regulations in most jurisdictions
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Special Precautions: Ship in original packaging, avoid temperature extremes, secure against leaks
Labelling Requirements: No mandatory labeling for bulk pharmaceutical ingredients in most regions, but must comply with pharmaceutical and workplace safety rules
OSHA Status: Not regulated as a hazardous chemical
TSCA Status: Exempt for pharmaceutical use
REACH Status: Substance of medicinal use, not subject to registration
WHMIS: Not classified as hazardous under Canadian regulations for laboratory chemicals
Other Regulations: Prescription drug status, compliance with DEA and FDA in USA, EMA in Europe
