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Product Name: Betamethasone Dipropionate
Chemical Name: 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
CAS Number: 5593-20-4
Recommended Use: Pharmaceutical active ingredient, topical corticosteroid
Manufacturer Information: Information provided by pharmaceutical supplier; check local inventory for emergency contact details
Emergency Phone Number: Refer to label or local regulations for specific contacts
SDS Revision Date: See company policy and regulatory requirements for most recent update cycle
Synonyms: Betaderm, Diprolene, Celestoderm V, Diprosone
GHS Classification: Not classified as a hazardous substance or mixture according to GHS standards for health and environment; may cause irritation, allergy, or effects related to corticosteroid activity upon chronic exposure
Label Elements: No special symbol; signal word may not apply
Physical Hazards: Low risk under normal handling, but as a steroid compound, it has potential for sensitization
Health Hazards: Possible allergic reactions, skin or eye irritation, negative effects from repeated exposure include immunosuppression or hormone disturbances
Environmental Hazards: Low levels can persist in water; potential risk for aquatic organisms
Specific Target Organ Toxicity: Endocrine, immune system
Other Hazards: May be harmful if absorbed through skin, ingested, or inhaled at high concentrations
Main Ingredient: Betamethasone Dipropionate
Chemical Formula: C28H37FO7
Purity: Greater than 98% in clinical grade material
Impurities: Minimal, process-related byproducts generally below 0.2% total by chromatographic assays
Other Ingredients: Pharmaceutical excipients or carriers present in formulated products; proprietary and may include solvents, suspending agents, creams, or ointment bases
Concentration Range: Typically 0.02%–0.05% in topical formulations; raw bulk powder is near 100% purity
Inhalation: Move person to fresh air; support breathing with oxygen if needed; seek medical attention for symptoms such as dizziness or respiratory upset
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; consult healthcare provider if irritation develops or persists
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, lifting eyelids to flush thoroughly; contact an ophthalmologist if symptoms do not resolve
Ingestion: Rinse mouth with water; do not induce vomiting; call poison control or seek medical evaluation, especially for large quantities or if symptoms appear
Acute Symptoms: May include headache, skin rashes, or irritation; large exposures can cause immunosuppression or endocrine imbalances
Advice for Healthcare Providers: Symptomatic treatment only; monitor for allergic reactions or unusual systemic effects
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam; avoid using strong water jets
Specific Hazards from Combustion: Thermal decomposition releases carbon oxides, fluorine compounds, possible toxic or irritating fumes
Firefighting Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Precautions: Evacuate area, cool containers with water spray, avoid inhaling combustion byproducts
Special Procedures: Isolate affected area, ventilate after fire is extinguished, collect run-off to prevent environmental contamination
Personal Precautions: Use personal protective equipment including gloves, goggles, and lab coats; avoid breathing dust or vapors
Environmental Precautions: Prevent entry into sewers, watercourses, or soil; report large spills to local authorities
Method for Containment and Clean-Up: Absorb spillage with inert material such as sand or earth; sweep up and place in proper waste disposal container; clean contaminated surface with soap and water
Decontamination: Ventilate area and wash with water and detergent; do not dry sweep to avoid aerosol generation
Waste Disposal: Dispose of collected material according to local hazardous waste regulations
Precautions for Handling: Use in well-ventilated areas; avoid generating dust or aerosols; practice good industrial hygiene such as handwashing after use
Safe Storage Conditions: Store in original, tightly closed containers away from light and moisture; recommended temperature is 2°C–8°C for pharmaceuticals, room temperature for raw material unless manufacturer specifies lower range
Incompatible Materials: Oxidizers, acids, bases may react unfavorably; segregate from other drugs and chemicals where feasible
Special Precautions: Restrict access to trained personnel; avoid direct contact or inhalation of dusts; label containers clearly to prevent accidental use
Control Parameters: No established workplace exposure limits; handle as a potent pharmaceutical compound
Engineering Controls: Use closed systems, local exhaust ventilation, or fume hoods to reduce airborne exposure
Personal Protective Equipment: Wear nitrile gloves, chemical splash goggles, lab coats, and use respiratory protection when dust or aerosols may be present
Hygiene Measures: Wash hands, face, and exposed skin thoroughly before eating, drinking, or smoking; keep unprotected personnel away
Environmental Controls: Prevent unintended release to water or soil, treat laboratory effluent before discharge
Appearance: White to off-white crystalline powder
Odor: Odorless or mild; not distinctive
Odor Threshold: Not applicable
pH: Not available
Melting Point: 232°C–237°C
Boiling Point: Not applicable; decomposes before boiling
Flash Point: Not determined; solid not expected to present high flash risk
Solubility: Insoluble in water, soluble in methanol, ethanol, and chloroform
Partition Coefficient (log Pow): Approximately 3.6
Vapor Pressure: Negligible at room temperature
Relative Density: Approx. 1.26 g/cm³
Other Properties: Stable under recommended storage and handling conditions; forms fine dust
Chemical Stability: Stable under normal ambient conditions and in original packaging
Reactivity: Non-reactive under standard industrial and storage environments
Hazardous Reactions: Strong oxidants can degrade product; acids and bases may alter potency or structure
Conditions to Avoid: Excessive heat, open flames, strong light, moisture, and incompatible chemicals
Decomposition Products: May yield carbon monoxide, carbon dioxide, fluorine compounds, and irritating vapors during thermal breakdown or combustion
Polymerization: Does not polymerize
Acute Toxicity: Low oral and dermal toxicity reported for topical pharmaceutical doses; large, repeated doses can suppress adrenal function and immunity
Routes of Exposure: Skin, eyes, inhalation, ingestion (less common in intended use)
Symptoms of Exposure: Rash, headache, endocrine or immunological disturbances with significant cumulative exposure
Chronic Effects: Immunosuppression, delayed healing, hormone imbalances, risk of Cushing-like symptoms with misuse
Carcinogenicity/Mutagenicity: Studies do not show significant risk under prescribed uses; limited data in occupational settings
Sensitization: Allergic skin reactions reported for some individuals
Ecotoxicity: Not acutely toxic to aquatic life in low concentrations, but persistence and stability raise concern for long-term impacts
Mobility: Limited mobility in soil; binds strongly to organic matter
Persistence and Degradability: Degrades slowly, especially in dark, cool environments; photolytic degradation possible outdoors
Bioaccumulation Potential: Moderate due to lipophilicity; chronic exposure risks to aquatic organisms possible
Other Adverse Effects: Avoid release into the environment; no evidence of ozone depletion
Waste Treatment Methods: Use licensed hazardous waste disposal contractors; incinerate or treat as chemical waste under local and federal regulations
Contaminated Packaging: Dispose of empty containers as hazardous pharmaceutical waste; do not reuse or recycle without proper cleaning
Additional Precautions: Do not discharge to surface waters or sewers; use designated pharmaceutical collections where available
UN Number: Not regulated for transport under most international rules
UN Proper Shipping Name: Betamethasone Dipropionate or related corticosteroid, non-hazardous
Hazard Class: Not classified as a transport hazard
Packing Group: No special requirements
Environmental Hazards: Not considered environmentally hazardous in transported quantities
Special Transport Precautions: Protect from physical damage, moisture, and sunlight; maintain temperature controls where required by finished product specifications
TSCA (United States): Not listed as a bulk industrial chemical
OSHA Status: Not classified as hazardous under US OSHA regulations for chemical exposure, but recognized as a potent pharmacological substance
WHMIS (Canada): Not controlled; pharmaceutical use subject to health regulations
REACH (EU): Pharmaceutical use exempt from most REACH registration requirements
Other Country-Specific Regulations: Controls apply for handling, use, and disposal under pharmaceutical and workplace health regulations
Labeling Requirements: Follow local and product-specific labeling for hazardous drugs or controlled medications
