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Substance Name: Betahistine Mesylate
Chemical Formula: C8H12N2 • CH4O3S
CAS Number: 5638-76-6
Synonyms: 2-(2-Methylpyridyl)ethylamine methanesulfonate
Recommended Use: Pharmaceutical intermediate, active pharmaceutical ingredient
Manufacturer/Supplier: Refer to product label or shipping documents
Emergency Contact Information: National Poison Center, local emergency medical provider
GHS Classification: Not classified as hazardous under GHS criteria for most end-user applications
Hazard Statements: May cause mild skin and eye irritation. Avoid inhalation of dust or direct contact.
Signal Word: Warning
Pictogram: Exclamation mark
Precautionary Statements: Wear gloves, use in well-ventilated area, wash hands thoroughly after handling
Potential Health Effects: Eyes: irritation possible. Skin: possible mild irritation. Inhalation: coughing, possible throat irritation. Ingestion: possible gastrointestinal upset.
Chemical Name: Betahistine Mesylate
Purity: >98%
Impurities: Trace byproducts from synthesis (less than 2%)
Molecular Weight: 227.3 g/mol
Main Ingredient: Betahistine Mesylate
Other Components: None significant at levels exceeding 1%
Inhalation: Move person to fresh air. Offer water if symptoms (cough, discomfort) appear. Seek medical advice if not resolved.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with water and soap. Seek medical help for persistent irritation.
Eye Contact: Immediately rinse with water for several minutes, lifting eyelids occasionally. Remove contact lenses. Get medical attention for ongoing irritation.
Ingestion: Rinse mouth with water. Give small quantities of water to drink. Do not induce vomiting. Obtain medical attention if large quantity ingested, symptoms persist, or discomfort occurs.
Note for Physicians: Provide symptomatic and supportive care. No specific antidote known.
Suitable Extinguishing Media: Use CO2, dry powder, alcohol-resistant foam, or water spray.
Specific Hazards: Combustion may produce carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides.
Special Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear.
Advice: Remove containers from fire area if possible. Prevent runoff from entering drains or water sources. Remain upwind and avoid inhalation of dust or smoke.
Personal Precautions: Use personal protective equipment including gloves, lab coat, safety glasses, dust mask or respirator suitable for fine powders.
Environmental Precautions: Prevent entry into waterways, sewers, basements, or confined areas. Avoid creating dusty conditions.
Containment and Clean-up: Sweep up, collect into suitable labeled containers for proper disposal. Rinse area with water after removal of bulk powder. Ventilate area.
Waste Disposal: Dispose of according to local, regional, and national regulations.
Handling: Minimize dust formation. Avoid breathing dust, direct skin or eye contact. Wear suitable protective equipment. Work in well-ventilated areas or fume hoods.
Hygiene Practices: Wash hands after handling. Do not eat, drink, or smoke in work area.
Storage: Store in tightly closed, sealed container. Place in a cool, dry, well-ventilated area away from sources of heat, ignition, incompatible substances (strong oxidizers, acids). Keep away from direct sunlight and moisture.
Incompatibilities: Strong acids, strong oxidizers, strong bases
Exposure Limits: No established occupational exposure limit for betahistine mesylate
Engineering Controls: Use local exhaust ventilation, fume hood, or process enclosure to keep airborne concentrations below exposure limits.
Personal Protective Equipment: Eyes: Chemical safety goggles. Skin: Chemical-resistant gloves, long sleeve lab coat. Respiratory: Dust mask or respirator rated for particulates.
Environmental Controls: Prevent spills or releases to the environment. Use containment for spills.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
Odor Threshold: Not determined
pH (1% Solution): Approximately 5-6
Melting Point: 147-153°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Non-flammable solid
Explosive Properties: No known explosive properties
Vapor Pressure: Negligible at room temperature
Vapor Density: Not determined
Solubility: Highly soluble in water, sparingly soluble in ethanol
Partition Coefficient (Log Kow): Not available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Decomposes on heating above 153°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Non-reactive under normal use and storage
Hazardous Reactions: No hazardous polymerization known
Conditions to Avoid: Heat, open flames, moisture, direct sunlight
Incompatible Materials: Strong acids, strong oxidizing agents, strong bases
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide during fire or decomposition
Acute Toxicity: Low toxicity by oral, dermal, and inhalation routes based on animal data and use history in medicine
LD50 (Oral, Rat): Over 2000 mg/kg
Irritation: May cause mild skin, eye, and respiratory irritation
Sensitization: No reports of sensitization from dermal exposure
Chronic Effects: Not classified as a carcinogen, mutagen, or reproductive toxin based on current data
Routes of Exposure: Skin, eyes, inhalation, ingestion
Target Organ Effects: Mainly gastrointestinal system with high doses; unlikely to reach such levels in workplace
Other Data: Long-term experience with betahistine in humans as a drug suggests low health risk when used properly
Ecotoxicity: Not classified as hazardous to aquatic or terrestrial life at standard release concentrations
Aquatic Toxicity: No measured fish or daphnia LC50 data available; no evidence of significant harm under normal use
Persistence and Degradability: Expected to degrade in environment; biodegradable with time
Bioaccumulative Potential: Low; based on chemical structure and use
Mobility in Soil: Likely to be mobile due to high water solubility
Other Adverse Effects: Avoid large releases to waterways; minimize environmental contamination through proper waste management
Waste Treatment Methods: Dispose unused product, contaminated equipment, and packaging through incineration or landfilling at licensed facility.
Disposal Container: Use sealed and labeled containers. Prevent spillage.
Special Precautions: Follow all national, regional, and local environmental regulations for pharmaceutical waste. Do not allow into drains, watercourses, or soil.
UN Number: Not regulated under current transport regulations
Proper Shipping Name: Not regulated
Transport Hazard Class: Not classified as hazardous for transport
Packing Group: Not applicable
Special Precautions for User: Keep container tightly sealed, avoid physical damage, keep dry
Environmental Hazards: Not classified as a marine pollutant
Transport in Bulk: Follow regional and national transport requirements. Ship in original or approved containers.
International Inventories: Check local regulatory listings (e.g., EINECS, TSCA) for status
Regulatory Status: Drug ingredient under medical product regulations in many regions; not regulated as hazardous
SARA Title III Sections 302, 304, 311, 312, 313: Not listed
California Proposition 65: Not listed as a cancer or reproductive toxin
WHMIS Classification (Canada): Not controlled
EU Regulations: Not classified as dangerous under CLP Regulation (EC) No 1272/2008
Other Information: Always follow workplace, national, and international guidelines for handling pharmaceutical materials
