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Product Name: Berberine Sulfate
Chemical Formula: C20H18NO4S
Synonyms: Berberine Sulphate, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium sulfate
CAS No.: 633-65-8
Manufacturer: Listed on product packaging and safety documentation
Recommended Use: Laboratory, chemical analysis, research, not for food or household use
Contact Information: Emergency contact details and manufacturer’s address as provided by supplier
GHS Classification: Acute Toxicity, Category 4; Eye Irritation, Category 2A; Skin Irritation, Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin and serious eye irritation; May cause respiratory tract irritation
Pictogram(s): Exclamation mark
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear protective gloves, eye/face protection. Do not eat, drink, or smoke while using this product.
Potential Health Effects: Eye contact leads to pain and redness. Skin absorption may irritate. Ingestion causes nausea, vomiting, or gastrointestinal discomfort.
Chemical Name: Berberine Sulfate
Concentration: ≥ 97% pure
Impurities: Trace organic synthesis byproducts, quality verified by batch analysis
Molecular Weight: 434.43 g/mol
EINECS No.: 211-199-0
Form: Crystalline powder (typically yellow)
Other Components: None present in hazardous amounts based on supplier’s specification and analysis
Inhalation: Remove victim to fresh air. Keep patient warm and at rest. Seek medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing. Wash affected skin with soap and a copious amount of running water. Consult a physician if irritation persists.
Eye Contact: Rinse eyes with water for at least 15 minutes, lifting eyelids intermittently. Seek immediate medical advice.
Ingestion: Do not induce vomiting. Rinse mouth with plenty of water. Never give anything by mouth to an unconscious individual. Contact a healthcare professional right away.
Most Important Symptoms: Redness, irritation, burning sensation, gastro-intestinal discomfort, headache in rare cases
Suitable Extinguishing Media: Use dry chemical, CO2, foam, or water spray as appropriate for surrounding materials
Special Hazards: Thermal decomposition may produce irritating or toxic fumes including carbon oxides, nitrogen oxides, and sulfur oxides
Protective Equipment: Firefighters wear self-contained breathing apparatus (SCBA) and full protective clothing
Advice: Move containers from fire area if it can be done without risk. Prevent run-off from entering drains or surface water.
Explosion Risk: Does not present significant explosion hazard under normal storage and handling; dust formation may create ignition risk in rare cases
Personal Precautions: Avoid breathing dust. Use appropriate personal protective equipment including gloves and eye/face protection.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains, waterways, or soil.
Methods for Cleanup: Sweep up, collect and place in a suitable container for proper disposal. Ventilate the area. Wash spill area with water once material is collected.
Spill Response: Contain dust, handle using appropriate PPE, report large spills to local authority if required
Handling: Work with product in a well-ventilated place. Avoid generating or breathing dust. Prevent contact with skin, eyes, and clothing. Wash hands before breaks and after handling.
Storage: Store in a tightly closed container in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidants or acids. Protect from light, moisture, and sources of ignition.
Specific Hazards: Container may become hazardous when empty. Residue can be just as dangerous as pure chemical.
Incompatibilities: Oxidizing agents, strong acids, bases
Occupational Exposure Limit: No specific TLV available for berberine sulfate; use general good hygiene practices
Engineering Controls: Local exhaust ventilation or process enclosure at points of dust generation
Personal Protective Equipment:
— Eye/Face Protection: Safety goggles, face shield for large quantities
— Skin Protection: Nitrile or neoprene gloves, lab coat, apron as necessary
— Respiratory Protection: Dust mask or NIOSH-approved respirator if dust levels exceed safe guidelines
Hygiene Measures: Do not eat, drink, or smoke in areas where material is handled. Wash hands after handling material, even if gloves are worn.
Appearance: Fine yellow crystalline powder
Odor: No distinct odor
Odor Threshold: Not established
pH: 4.0 – 6.0 (aqueous solution)
Melting Point: 200°C (decomposes)
Boiling Point: Not applicable
Flash Point: Not applicable
Evaporation Rate: Not determined
Flammability: Not easily ignitable
Explosion Limits: Not determined for this material
Vapor Pressure: Not relevant (solid at RT)
Vapor Density: Not applicable
Relative Density: Difficult to specify, but typically ≥1.25 g/cm3
Solubility: Slightly soluble in water, insoluble in most organic solvents
Partition Coefficient (log Kow): No data available
Auto-ignition Temperature: Not available
Decomposition Temperature: >200°C
Chemical Stability: Stable under recommended handling and storage conditions
Possibility of Hazardous Reactions: Avoid contact with oxidizing agents, strong acids and bases
Conditions to Avoid: Prolonged exposure to heat, light, moisture
Decomposition Products: Toxic gases and fumes such as carbon oxides, nitrogen oxides, sulfur oxides can be generated at elevated temperatures or upon combustion
Polymerization: Does not undergo dangerous polymerization under normal conditions
Acute Toxicity: Harmful if swallowed in quantity. Single-dose animal studies report oral LD50 values above 2000 mg/kg (rat), though symptoms can appear at lower exposure.
Routes of Exposure: Inhalation, skin absorption, eye and oral
Symptoms of Exposure: Burning sensation in eyes, skin; nausea, vomiting, abdominal pain, headache or dizziness on ingestion or inhalation
Chronic Effects: Not fully studied; long-term repeated exposure has shown possibility of liver enzyme alteration in animal data reported in scientific literature
Carcinogenicity: No data from IARC, NTP, or OSHA showing classification as a carcinogen
Other Data: No known teratogenic or reproductive toxicity risks in humans. Always use with caution to avoid overexposure.
Aquatic Toxicity: Environmental effects not fully assessed, but limited evidence suggests low toxicity to aquatic organisms and rapid breakdown in soil
Mobility in Soil: Tends to remain bound to soil particles, limited mobility
Persistence and Degradability: Product expected to be biodegradable
Bioaccumulation: Significant bioaccumulation not observed in screening studies
Other Adverse Effects: No notable impact at quantities typically handled in laboratory or research facility. Always contain spill and prevent release to environment wherever possible.
Disposal Methods: Collect and transfer to a suitable waste container, label, and dispose of according to national and local regulations for hazardous organic chemicals
Container Disposal: Empty containers may hold product residue; treat as hazardous waste. Rinse only if instruction is provided by qualified personnel.
Do Not: Pour into drains, sewers, or natural water bodies. Avoid uncontrolled release and open burning.
UN Number: Not classified as dangerous goods for transport by air, sea, or land under standard shipping regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Special Precautions: Secure packaging, avoid spillage, ensure compatibility with other goods in transit
Labeling: Follow all standard labeling requirements for non-dangerous chemicals as provided by national or international transport regulations
US TSCA: Listed on TSCA Inventory
EU REACH: Exempt or registered for scientific research and development
Canada DSL/NDSL: Check specific government database for import or sale
SARA Title III: Not classified as hazardous under SARA Title III
California Proposition 65: Product not listed
Other Regulations: Always review regional guidelines on workplace safety, labeling, and environmental release to stay compliant. Handle all documentation and reporting as described by national chemical safety authorities.
