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Product Name: Benserazide Hydrochloride
CAS Number: 14919-77-8
Synonyms: Serazide HCl, Ro 4-4602 Hydrochloride
Molecular Formula: C10H15N3O5·HCl
Manufacturer: Pharmaceutical chemical suppliers, research labs
Intended Use: Research and pharmaceutical manufacturing
Contact for Information: Please consult supplier's technical or safety services
Emergency Phone Number: National chemical safety hotlines, local emergency services
Classification: Harmful if swallowed, possible skin and eye irritant
GHS Label Elements: Exclamation mark, health hazard symbol
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation
Precautionary Statements: Wash hands after handling, avoid inhalation or skin contact, wear eye protection
Potential Health Effects: Shortness of breath, skin irritation, eye redness, gastrointestinal discomfort
Environmental Risk: Potential hazard to aquatic environments if improperly disposed
Chemical Identity: Benserazide Hydrochloride
Concentration: 100% active pharmaceutical ingredient
Impurities: Residual solvent traces possible depending on production batch
Component Percentages: No significant excipients, typically supplied pure for formulation
Molecular Weight: 289.7 g/mol (as hydrochloride salt)
Inhalation: Move affected person to fresh air immediately; seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing; wash exposed area thoroughly with soap and water; consult physician if irritation develops
Eye Contact: Rinse eyes gently with plenty of water for at least fifteen minutes, ensuring eyelids are held apart; medical assessment strongly advised
Ingestion: Rinse mouth with water; do not induce vomiting; obtain immediate medical guidance
Other Recommendations: Emergency medical staff should receive product safety information to effectively manage exposure
Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, foam
Unsuitable Extinguishing Media: High-pressure water jets could spread contaminated material
Specific Hazards: Combustion may create nitrogen oxides, hydrogen chloride vapor, other toxic gases
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Explosion Risk: No specific explosion hazard at ambient temperatures; powder dispersion in air may create dust clouds with localized risk
Other Considerations: Vigilant containment of water runoff to prevent environmental contamination
Personal Precautions: Evacuate nonessential personnel; ensure adequate ventilation; use personal protective equipment (PPE)
Environmental Precautions: Block further entry into sewers, groundwater or surface water
Cleanup Methods: Collect spilled powder with an appropriate tool; place residue in sealed containers for disposal
Decontamination: Wash the area with water and detergent after dry clean-up, ensuring all residue is removed
Further Precautions: Avoid creating airborne dust; workers must wear respirators if powder is likely to become airborne during cleanup
Handling: Keep containers tightly closed; avoid formation and inhalation of dust; work in a chemical fume hood
Technicians' Advice: Wear gloves, protective clothing, and safety goggles; remove contaminated clothing before breaks
Storage Conditions: Store in cool, dry, well-ventilated areas away from incompatible materials such as oxidizers or strong bases
Container Materials: Use high-quality, sealable glass or plastic vessels capable of containing organic compounds
Incompatibilities: Segregate from acids, oxidizing agents, and hygroscopic materials
Occupational Exposure Limits: No established OSHA or NIOSH workplace exposure limits for benserazide hydrochloride
Engineering Controls: Handle only in well-ventilated areas or under fume extraction hoods
Personal Protective Equipment: Wear appropriate disposable gloves, laboratory coats, and protective eyewear
Respiratory Protection: Use a NIOSH-approved respirator if dust formation is possible
Hygiene Recommendations: Wash hands and skin thoroughly after working with the substance to prevent accidental ingestion or dermal absorption
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (in water): Not available
Solubility: Highly soluble in water, slightly soluble in ethanol, insoluble in nonpolar solvents
Melting Point: 246-250°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Density: Approximately 1.7 g/cm³
Vapor Pressure: Negligible under ambient conditions
Partition Coefficient (log Kow): Data not available
Chemical Stability: Stable under recommended storage and handling conditions
Decomposition: Decomposes at elevated temperatures, emitting toxic fumes including nitrogen oxides and hydrochloric acid
Hazardous Reactions: Avoid contact with strong oxidizers, reducing agents, and acids which can initiate hazardous reactions or decomposition
Polymerization: No risk of hazardous polymerization
Sensitivity to Physical Impact: Not sensitive
Environmental Sensitivity: Protect from moisture; prolonged exposure can result in hydrolysis and loss of potency
Acute Toxicity: Harmful if swallowed; LD50 (oral, rats) estimated between 500-1000 mg/kg
Skin Contact: May cause irritation, particularly after repeated or prolonged exposure
Eye Contact: Dust or solution can cause significant eye irritation and stinging
Chronic Effects: No definitive evidence of carcinogenicity or mutagenicity, but extended inhalation and skin contact should be avoided
Target Organs: Possible liver and kidney involvement based on related compounds and rodent data
Reproductive Toxicity: No clinical data available; prudent to avoid exposure during pregnancy and breastfeeding
Other Routes: Limited absorption through healthy skin, risk increased by damaged skin or excessive contact
Aquatic Toxicity: May pose a risk to aquatic organisms if released in quantity; precise EC50 not published
Persistence and Degradability: Chemical is expected to undergo slow biodegradation; breakdown products may maintain toxicity
Bioaccumulation Potential: Low risk as molecule is water-soluble and unlikely to concentrate in natural environments
Mobility in Soil: Anticipated moderate mobility due to water solubility; risk of contamination of groundwater if improperly discarded
Other Environmental Hazards: Strict containment and qualified waste disposal prevent unnecessary contamination risks
Waste Handling: Dispose of unused material, contaminated PPE, cleanup residue, and other related waste as hazardous chemical waste
Disposal Methods: Transfer to a high-temperature incinerator operating within environmental protection guidelines for organic chemical waste
Container Disposal: Deface labels after emptying and triple rinse containers before collection for secure disposal
Non-Household Waste: Involve licensed chemical waste contractors for offsite collection and destruction
Legal Framework: Follow local, regional, and national chemical waste regulations to reduce environmental risk
UN Number: Not classified as a dangerous good for transport under most regulatory frameworks
Proper Shipping Name: Pharmaceutical intermediate, non-hazardous by technical definition
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Special Transport Precautions: Use tightly closed, labeled containers; keep away from food, feed, and incompatible goods
Regulatory Guidance: Consult carrier and local port health authorities for current regional requirements
Workplace Regulations: Benserazide hydrochloride falls under chemical hazard communication laws; ensure all label and SDS information remains accessible
Inventory Status: Listed in global chemical inventories for research and development use
Control Measures: No specific workplace exposure or environmental discharge limits, yet local workplace safety rules for handling laboratory drugs still apply
Hazard Labeling: Complies with GHS and OSHA Hazard Communication Standard labeling, based on potential for irritation and toxicity
Additional Controls: Adherence to Good Laboratory Practice (GLP) and relevant pharmaceutical handling standards provides additional worker and environmental safety
