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Product Name: Benproperine Phosphate
Synonyms: 1-[2-(2-benzylphenoxy)ethyl]piperidine phosphate
Chemical Formula: C21H27NO4P
CAS Number: 2153-57-9
Recommended Uses: Cough suppressant in pharmaceutical preparations
Supplier Details: Pharmaceutical manufacturer contact—see packaging
Emergency Contact Number: Local or national poison control and health & safety officer responsible for material safety management
GHS Classification: Harmful if swallowed, harmful in contact with skin, respiratory tract irritation
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract; may be harmful if ingested in large quantities
Precautionary Statements: Wear protective equipment, avoid inhalation, prevent contact with skin and eyes
Signal Word: Warning
Pictograms: Exclamation mark (irritant) symbol
Other Hazards: No known explosive or flammable properties under normal use conditions; dust may create irritant conditions in confined spaces
Chemical Name: Benproperine Phosphate
PURITY: ≥98% (Active pharmaceutical ingredient standard)
Impurities: Less than 2% depending on manufacturer batch specification
Other Ingredients: None identified in raw API grade; excipients present only in formulated drugs
EC Number: 218-437-3
Molecular Weight: 390.4 g/mol
Inhalation: Move person to fresh air and keep at rest in a comfortable position for breathing, seek medical attention if symptoms persist
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing for at least 15 minutes, obtain medical attention
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, seek medical attention if irritation develops
Ingestion: Rinse mouth thoroughly, drink water, do not induce vomiting unless instructed by medical personnel, seek immediate medical assistance
Acute Symptoms: Mild to moderate irritation, coughing, headache, nausea if significant ingestion or inhalation occurs
Advice For Medical Personnel: Treat symptomatically, monitor respiratory and cardiovascular function, provide supportive care
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray
Unsuitable Extinguishing Media: Do not use jet of water to avoid dust spread
Specific Hazards: Hazardous decomposition may produce phosphorus oxides, nitrogen oxides, carbon monoxide, and carbon dioxide in a severe fire
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective clothing
Special Precautions: Prevent runoff into water sources and sewers, ventilate area after fire is extinguished
Personal Precautions: Wear appropriate safety gear; gloves, safety goggles, dust mask or respirator
Environmental Precautions: Prevent entry of spilled substance into sewers, soil, and water bodies, inform relevant authorities if environmental contamination is likely
Containment Methods: Sweep up material without creating airborne dust, use damp cloth or vacuum equipped with HEPA filtration
Cleaning Up: Collect material in sealable containers for proper disposal, decontaminate affected area with water and detergent
Other Recommendations: Avoid direct contact, ventilate impacted area thoroughly after clean-up, do not reuse cleaning materials contaminated with substance
Handling Practices: Use only in well-ventilated areas, avoid breathing dust and contact with skin or eyes, handle with care to avoid spills and dust formation
Storage Conditions: Store in a tightly closed, labeled container, keep away from incompatible substances such as strong oxidizers and acids
Temperature Range: Recommended storage below 30°C, protect from moisture and direct sunlight
Incompatibilities: Strong bases, strong acids, oxidizing agents
Other Precautions: Keep out of reach of children and untrained individuals, ensure appropriate signage on storage areas
Exposure Limits: No specific occupational exposure limits established; minimize dust exposure
Engineering Controls: Use exhaust ventilation, enclosed processes, or personal protective equipment to reduce airborne exposure
Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat or protective clothing, dust mask, or appropriate NIOSH-certified respirator when handling powder
Hygiene Measures: Wash hands thoroughly after handling, avoid eating, drinking, or smoking in areas where product is used, launder contaminated clothing before reuse, do not breathe dust
Appearance: White or almost white crystalline powder
Odor: Odorless
pH: No information available for solid; typically neutral in suspension
Solubility: Soluble in water, ethanol, methanol; insoluble in non-polar solvents
Melting Point: Approximately 198°C to 204°C
Boiling Point: Decomposes before boiling
Flash Point: Data not available; not expected to present significant flammability hazard
Vapor Pressure: Negligible at ambient temperature
Relative Density: Not established precisely; bulk density varies by crystallization method
Chemical Stability: Stable under normal temperatures and pressures in well-sealed containers
Conditions to Avoid: Excess moisture, extreme temperatures, open flames, direct sunlight
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition: Phosphorus oxides, nitrogen oxides, carbon monoxide, and carbon dioxide can form on combustion or high-temperature decomposition
Polymerization: No known risk for hazardous polymerization under normal storage and usage
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Primary Effects: May cause short-term irritation of eyes, skin, and respiratory mucosa; ingestion can lead to nausea, dizziness, and headache
Acute Toxicity: LD50 (oral, rat): approximately 1,000 mg/kg; data from animal studies
Chronic Effects: Risk of liver or kidney involvement based on excessive or prolonged occupational exposure; no evidence for carcinogenicity or reproductive toxicity in animal testing
Sensitization: Not expected to cause allergic sensitization, though rare individual cases not ruled out in general population
Other Information: No known mutagenicity based on laboratory screening assays
Ecotoxicity: Not highly toxic to aquatic life; avoid uncontrolled release into waterways
Degradability: Likely to undergo slow abiotic and/or biotic degradation in soil and water
Bioaccumulation Potential: Low, given chemical structure and observed water solubility
Mobility in Soil: Moderate, possible leaching if spilled in large quantities
Other Concerns: Product not expected to persist or accumulate in the food chain
Product Disposal: Collect for chemical incineration or landfill in accordance with local environmental regulations, do not release into environment
Packaging Disposal: Triple rinse containers before disposal, dispose of used packaging and cleaning materials as hazardous chemical waste
Recommended Practices: Work with licensed hazardous waste handler, never dispose into regular municipal waste streams, keep documentation of disposal
UN Number: Not classified as dangerous goods for transport purposes under IATA, IMDG, ADR
Proper Shipping Name: Benproperine Phosphate
Hazard Class: Not regulated as hazardous cargo
Packing Group: Not applicable
Environmental Hazards: None under standard shipment circumstances
Special Precautions: Avoid rough handling, prevent moisture uptake, keep container sealed and labeled during transit
Regulatory Status: Prescription pharmaceutical ingredient, subject to drug safety regulation in most countries
Safety Legislation: Covered by standards for occupational health and safety, hazardous materials, and environmental control
Labeling Requirements: Product identifier, hazard symbols, supplier contact required on containers
Compliance: Must meet relevant manufacturing, usage, handling, and disposal controls under local laws and international conventions
Other Notable Regulations: Not listed as carcinogen or VOC under EU REACH, US TSCA, or IARC
