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Chemical Name: Benorilate
Synonyms: Acetylsalicylic acid ester with paracetamol, Benorylate
CAS Number: 5003-48-5
Molecular Formula: C17H15NO5
Molecular Weight: 313.31 g/mol
Recommended Use: Analgesic, antipyretic compound
Manufacturer Details: [Contact company for specific data]
Emergency Contact: Access local emergency telephone number for chemical exposure
GHS Classification: Irritant, harmful if swallowed
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory discomfort, ingestion may lead to gastrointestinal disturbances and possible toxicity
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin, eyes
Chronic Effects: Extended exposure can potentially affect liver, kidneys, and gastrointestinal tract, especially in sensitive individuals
Target Organs: Liver, kidneys, eyes, skin
Precautionary Statements: Avoid inhalation of dust, wear personal protective equipment, handle in a well-ventilated area, keep away from food and drink
Benorilate: Pure compound, typically 98-100% by weight
Impurities: Trace levels of related esters and unreacted starting materials
Additives: None intentionally added
Physical State: Solid (powder or crystalline)
Color: White to off-white
Odor: Little to none detected at room temperature
Inhalation: Remove from exposure, move to fresh air, seek medical advice if symptoms like cough or shortness of breath persist
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, consult a physician if irritation develops
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, seek medical attention if irritation or pain remains
Ingestion: Rinse mouth with water, do not induce vomiting, consult poison control or a physician right away
Chief Symptoms: Nausea, headache, stomach upset, skin or eye redness
General Advice: Always seek prompt medical assessment for exposure involving children, pregnant individuals, or those with pre-existing health concerns
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Unsuitable Media: Avoid use of direct high-pressure water streams, which may spread powder
Special Hazards: Combustion releases toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Use full protective gear and self-contained breathing apparatus to avoid inhaling fumes
Firefighting Advice: Approach fire from upwind, cool containers with water if exposed to heat, prevent run-off from contaminating water supplies
Personal Precautions: Wear gloves, eye protection, dust mask or respirator, avoid creating dust clouds
Environmental Precautions: Prevent entry into drains, soil, or waterways, contain spill using non-combustible absorbent material such as sand or vermiculite
Cleanup Methods: Scoop up spilled product, place in labeled container for disposal, ventilate area thoroughly, decontaminate surfaces with water and mild detergent
Reporting: Notify relevant local authorities in the event of a large spill or environmental release
Handling: Avoid inhalation, ingestion, and skin or eye contact by using approved protective gear, maintain good industrial hygiene, wash hands after use, avoid food and drink in the working area
Storage: Store in tightly closed, labeled containers in a cool, dry, well-ventilated environment away from incompatible substances such as strong oxidizers, keep away from direct sunlight and moisture, restrict unauthorized access
Incompatibilities: Strong acids, bases, oxidizers
Shelf Life: Maintain within the recommended storage temperature range to ensure stability and potency
Occupational Exposure Limits: No specific regulatory limits established for Benorilate; handle as a nuisance dust with exposure control at 10 mg/m3 (total dust) as a guideline
Engineering Controls: Use local exhaust ventilation, enclose processes when possible, provide eyewash stations and safety showers
Respiratory Protection: Use approved dust mask or respirator to limit inhalation of fine particles
Skin Protection: Wear suitable gloves (nitrile or latex), long-sleeved clothing, and lab coats
Eye Protection: Wear chemical safety goggles or face shield
General Hygiene: No eating, drinking, or smoking in area; wash hands with soap and water after handling
Appearance: White to slightly off-white crystalline powder
Odor: Faint or no odor
Molecular Weight: 313.31 g/mol
Melting Point: 110-113°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water; freely soluble in alcohol and organic solvents
pH (saturated solution): Neutral to slightly acidic
Vapor Pressure: Negligible at ambient temperatures
Density: About 1.35 g/cm3
Partition Coefficient (log Kow): 2.1 - 2.4 (estimated)
Stability: Stable under recommended storage conditions
Chemical Stability: Stable under normal handling and storage conditions
Conditions to Avoid: Heat, moisture, open flames, incompatible chemicals
Incompatible Materials: Strong acids, alkalis, oxidizing agents
Hazardous Decomposition Products: Toxic fumes of nitrogen oxides, carbon monoxide, and carbon dioxide may form on combustion or decomposition
Possibility of Hazardous Reactions: May react exothermically with strong oxidizing substances or acids
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: Oral LD50 (rat): estimated > 1000 mg/kg
Skin and Eye Irritation: Causes moderate irritation, especially with repeated contact
Symptoms of Exposure: Nausea, headache, abdominal pain, skin redness, eye discomfort
Chronic Toxicity: Long-term or high-level exposure can adversely affect the liver and kidneys; pre-existing health problems may increase susceptibility
Carcinogenicity: No classification as carcinogen by IARC, NTP, OSHA
Mutagenicity: Not expected to be mutagenic based on structure and analog data
Reproductive Toxicity: No conclusive evidence; use with care if pregnant or nursing
Environmental Fate: Data indicate Benorilate has low solubility in water and limited mobility in soil
Persistence and Degradability: Expected to be slowly biodegradable; breakdown products may include para-aminophenol or salicylic acid
Bioaccumulation Potential: Low bioaccumulation risk, log Kow indicates moderate partitioning; aquatic organisms unlikely to concentrate it
Aquatic Toxicity: Limited toxicity to Daphnia, fish, and algae at concentrations observed in accidental releases
Soil and Groundwater: Avoid contamination of soil and groundwater to protect wildlife and potable water supplies
Further Information: Use best practices to minimize environmental discharge during use and disposal
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations; use licensed chemical disposal contractor if available
Material Waste Class: Chemical waste, non-hazardous (if uncontaminated); contaminated material should be handled as hazardous
Packaging Disposal: Triple rinse empty containers, offer for recycling or dispose of as hazardous waste if contaminated
Avoid: Uncontrolled discharge to drains, surface waters, or environment
Special Instructions: Log all disposals for traceability and regulatory compliance
UN Number: Not regulated for transport under UN, IMDG, IATA, ADR
Proper Shipping Name: Not restricted
Transport Hazard Class: Not classified as dangerous good
Packing Group: Not applicable
Label Requirements: None required for carriage but maintain caution tags on bulk containers
Environmental Hazards: None identified through transport experience
Special Precautions: Protect from mechanical shock, moisture, and direct sunlight during loading, transit, and unloading
TSCA Status (US): Listed
EINECS / ELINCS (Europe): Listed
DSL / NDSL (Canada): Notified substance, regulatory consultation advised
REACH Status (EU): Registration required above threshold quantities
SARA Title III (US): Not listed as Extremely Hazardous Substance
OSHA Status: Not classified as hazardous chemical at normal usage levels
WHMIS (Canada): Not classified, handle using best safety practices
Other Regulations: Observe all local, national, and international chemical safety protocols relevant to storage, use, and disposal of pharmaceuticals and chemicals
