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Product Name: Beclometasone Butyrate
Chemical Name: 9-chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-butyrate
CAS Number: 5534-09-8
Recommended Use: Pharmaceutical corticosteroid; research chemical
Supplier: Pharmaceutical manufacturer or research supplier relevant to the region
Emergency Contact: Refer directly to local poison control helpline or manufacturer’s emergency number
Molecular Formula: C28H37ClO7
Molecular Weight: 520.04 g/mol
GHS Classification: Not classified as hazardous under GHS for most workplace exposures; avoid ingestion, inhalation, or skin/eye contact
Physical Hazards: Fine powdered form may cause dust explosion in air
Health Hazards: Overexposure may cause irritation to skin, eyes, respiratory tract; repeated contact may disrupt hormone systems, suppress immune function
Signal Word: Warning
Hazard Statements: May cause respiratory irritation, can be harmful if swallowed or inhaled, long-term exposure affects adrenal glands
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, wear suitable protective equipment
Substance: Pure Beclometasone Butyrate
Concentration: 98–100% by weight
Impurities: Minor synthetic byproducts or degradation products, generally below 1% w/w
Other Components: None considered significant for safety unless supplied as a formulated drug
Inhalation: Move exposed person to fresh air, loosen clothing, look for signs of difficulty breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and mild soap, monitor for irritation or allergic reaction
Eye Contact: Flush eyes gently with running water for at least 15 minutes, hold eyelids open, seek medical help immediately
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical staff, get immediate medical attention
Most Important Symptoms: Burning sensation, dryness, respiratory distress, nausea, hormonal disruption
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam
Unsuitable Media: Direct water jet may spread powdered chemical
Specific Hazards: Combustion releases toxic fumes—hydrogen chloride, carbon oxides
Protective Equipment: Wear full firefighting gear and self-contained breathing apparatus
Firefighting Instructions: Evacuate area, avoid breathing smoke or fumes, cool unopened containers near fire with water
Explosion Data: Avoid creating dust clouds; fine powder may contribute to dust explosions in confined spaces
Personal Precautions: Wear gloves, chemical splash goggles, NIOSH-approved dust mask
Environmental Precautions: Prevent material from entering drains, watercourses, or soil
Cleanup Methods: Sweep up powder without causing dust; use damp absorbent material to reduce airborne particles
Decontamination: Wash contaminated surfaces with water and detergent; dispose of cleanup materials in accordance with regulations
Handling: Work in well-ventilated area, minimize dust generation, avoid contact with skin and eyes, wash hands after handling
Storage Conditions: Store in tightly closed original container, in cool, dry, and well-ventilated place, away from incompatible substances like strong acids, oxidizers
Specific Requirements: Keep away from light to slow degradation, maintain humidity control to prevent clumping or caking
Hygiene Measures: Do not eat, drink, or smoke while handling; change contaminated clothing promptly
Exposure Limits: No occupational exposure limits set for pure beclometasone butyrate; minimize inhalation and dermal exposure as with other corticosteroids
Engineering Controls: Use local exhaust ventilation when handling powder, enclose processes if possible
Personal Protective Equipment: Use disposable nitrile gloves, lab coat, chemical splash goggles or face shield, certified dust respirator for high volume usage
Environmental Controls: Avoid release to waterways, use approved waste containers, ensure air filtration in preparation areas
Appearance: White or almost white fine powder
Odor: Odorless or faint chemical smell
pH: Not applicable (insoluble in water)
Melting Point: 215–220 °C
Boiling Point: Decomposes before boiling
Flash Point: Not easily flammable; specific data not established
Solubility: Insoluble in water, soluble in chloroform, methanol, ethanol
Vapor Pressure: Negligible at room temperature
Density: About 1.26 g/cm³
Partition Coefficient (log P): Estimated 2–3
Stability: Stable under recommended storage, protected from moisture and light
Chemical Stability: Stable at ambient temperatures and recommended storage conditions
Conditions to Avoid: Exposure to extreme heat, light, moisture, strong oxidizers, acids
Incompatible Materials: Oxidizing agents, strong acids, alkalis
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide and dioxide
Reactivity: No hazardous polymerization, avoid incompatible substances to reduce risk of degradation
Acute Toxicity: Very low toxicity by oral, skin, or inhalation exposure in small amounts typically used in research or formulation
Chronic Effects: Prolonged or repeated exposure may suppress adrenal glands, affect immune response, cause hormonal imbalance
Carcinogenicity: No evidence of carcinogenic potential in current literature
Reproductive Toxicity: High, prolonged exposures may disturb fetal development based on corticosteroid properties
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Irritation: Can cause mild to moderate irritation to eyes, respiratory tract; dry skin with repeated exposure
Sensitization: Not widely reported; handle as a potential sensitizer
Ecotoxicity: Expected to present low acute toxicity to aquatic organisms but risk bioaccumulation through runoff and chronic exposure
Persistence: Moderately persistent; not expected to degrade rapidly in environment
Bioaccumulation Potential: Medium; corticosteroids may bioaccumulate in aquatic and terrestrial organisms
Mobility in Soil: Low water solubility limits movement; binds to organic matter
Aquatic Toxicity: Data limited; err on the side of caution by preventing release to waterways
Waste Disposal: Dispose of through licensed hazardous chemical disposal contractor
Contaminated Packaging: Incinerate or landfill containers in compliance with local, state, and federal regulations
Precautions: Do not flush down the drain or allow entry into surface water, sewer, or soil
Recommended Methods: Chemical incineration under controlled conditions
UN Number: Not assigned for non-bulk shipments under most regulations
Proper Shipping Name: Not regulated for ground, air, or sea unless packed as a hazardous substance
Hazard Class: Not classified as hazardous for shipping in small quantities
Packing Group: Not applicable under most conditions
Special Transport Precautions: Prevent breakage, minimize dust release, keep moisture out during transport
TSCA Inventory: Not listed for commercial use; prescription/research only
REACH Status: Exempt as drug or research active ingredient in EU
OSHA Hazards: No specific OSHA PEL; general dust and corticosteroid safety protocols apply
WHMIS Classification (Canada): Exempt as pharmaceutical product
Other Regulations: Drug authorities may restrict use to licensed holders only; all handling must follow regional medicine and workplace safety rules
