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Product Name: Bambuterol Hydrochloride
Chemical Formula: C18H29N3O5·HCl
Chemical Name: 3-[(RS)-2-(tert-butylamino)-1-hydroxyethyl]phenyl N,N-dimethylcarbamate hydrochloride
CAS Number: 81732-46-9
Intended Use: Pharmaceutical intermediate, active ingredient in bronchodilator medications
Manufacturer Contact: See supplier documentation for emergency contact details, address, phone.
Synonyms: Bambuterol HCl, Bambec
Emergency Phone Number: Refer to material label or manufacturer’s paperwork.
Classification: Irritant to eyes and skin, may be harmful if swallowed or inhaled; GHS classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 2
Hazard Statements: Causes eye and skin irritation, may cause respiratory irritation, toxic to aquatic life, may cause allergic skin reaction
Signal Word: Warning
Hazard Pictograms: Exclamation mark, health hazard
Route of Entry: Inhalation, ingestion, dermal contact
Potential Health Effects: Shortness of breath, coughing, skin redness or rash, eye discomfort, nausea, headaches possible from prolonged exposure
Environmental Risk: Can affect aquatic ecosystems if released in significant quantities.
Component: Bambuterol Hydrochloride
Concentration: Typically >98% pure
Chemical Identity: C18H29N3O5·HCl
Impurities: Not expected to be present in hazardous quantities under standard use
Stabilizers or Additives: No known additives contained
Molecular Weight: 406.90 g/mol
Relevant Exposure Limits: No occupational exposure limit established specifically for this compound yet.
Inhalation: Move individuals to fresh air immediately, monitor for breathing difficulties, seek medical help if symptoms persist
Skin Contact: Rinse thoroughly with water and soap, remove contaminated clothing, medical attention if irritation continues
Eye Contact: Flush with water for at least 15 minutes, remove contact lenses if present, continue rinsing, consult medical professional
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice urgently, monitor for symptoms like nausea or vomiting
Important Note: Individuals assisting should use gloves and avoid direct contact with contaminated material.
Suitable Extinguishing Media: Dry chemical, CO2, water spray, foam
Unsuitable Extinguishing Media: Direct water jet in large quantities may spread powder
Special Hazards: May release toxic fumes of hydrogen chloride, nitrogen oxides, carbon monoxide under fire conditions
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear
Advice for Firefighters: Avoid inhaling gases and dust, isolate spill area, prevent water runoff from entering drains or watercourses
Combustion Products: Smoke, poisonous gases including HCl and NOx possible.
Personal Precautions: Wear protective clothing, gloves, eye protection, dust mask or respirator
Environmental Precautions: Prevent powder from entering water systems or soil, contain spillage at source
Cleanup Procedures: Collect spillage with a non-sparking tool, avoid creating dust, store in sealed containers for disposal
Spill Area Management: Ventilate area well, wash with copious amounts of water after removal of material
Decontamination Procedures: Use appropriate cleaning agents, limit exposure to cleaning staff.
Handling Precautions: Work in well-ventilated areas, avoid breathing dust or fumes, wash hands before eating or drinking, avoid direct skin and eye contact
Equipment: Local exhaust ventilation, dust collection systems if processing large amounts
Storage Conditions: Keep tightly closed in a cool, dry, well-ventilated area, protected from light and moisture
Incompatibles: Strong acids, strong bases, oxidizing or reducing agents
Packaging: Use original containers or those compatible with pharmaceutical powders; label clearly
Handling Advice: Segregate from foodstuffs, medicines intended for other uses, and animal feeds.
Engineering Controls: Use fume hoods or dust extraction during weighing or transferring; implement local exhaust ventilation for bulk work
Personal Protective Equipment: Safety goggles, NIOSH-approved respirator, chemical-resistant gloves, lab coat
Hygiene Measures: Wash hands thoroughly after handling, keep separate from street clothing, avoid eating or drinking during work
Exposure Guidelines: No set occupational exposure limits for this compound; handle as a potentially hazardous pharmaceutical
Monitoring: Regular air quality checks in production or compounding environments.
Appearance: White or almost white, crystalline powder
Odor: No distinct odor
pH (aqueous solution): Approximately 4–5 (1% solution)
Melting Point: 220–225°C (decomposes)
Solubility: Soluble in water, very slightly soluble in ethanol
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not relevant under normal storage conditions
Partition Coefficient (log P): Not established for salt form
Flash Point: Not easily flammable; no data for flash point
Density: Not specifically measured; comparable to other hydrohalide salts.
Chemical Stability: Stable under recommended storage conditions, decomposes on exposure to heat or acids
Possibility of Hazardous Reactions: May react with strong oxidizers, risk of releasing toxic gases if mixed with acids
Conditions to Avoid: Moisture, open flames, high temperatures, direct sunlight
Incompatible Materials: Strong acids, powerful oxidizing agents, strong alkali
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride, carbon monoxide and dioxide on heating
Shelf Life: Check product label for batch-specific expiry.
Acute Toxicity: Oral LD50 (rat): 200–400 mg/kg, moderate toxicity
Chronic Toxicity: No detailed long-term studies in humans; animal studies suggest low risk at therapeutic levels
Potential Routes of Exposure: Inhalation, ingestion, dermal and ocular
Effects from Short-Term Exposure: Throat irritation, headache, dizziness, gastrointestinal upset, skin rash, eye redness
Effects from Long-Term Exposure: No definitive evidence; repeated exposure may lead to sensitization or allergic reactions
Carcinogenicity: Not classified as carcinogenic
Mutagenicity: Animal and in vitro tests show no mutagenic risks
Reproductive Toxicity: Not documented in standard exposure settings
Medical Conditions Aggravated by Exposure: Individuals with respiratory issues, asthma, allergies may react adversely.
Aquatic Toxicity: Toxic to aquatic organisms even at low concentrations, can cause long-lasting harmful effects in aquatic environments
Persistence and Degradability: Compound may persist in the environment, breaks down slowly in soil or water
Bioaccumulative Potential: No measurable bioaccumulation expected based on molecular size and water solubility
Mobility in Soil: Readily soluble, could migrate in moist soil or water runoff
Environmental Precautions: Limit release to water systems, treat all spills as hazardous
Further Details: Avoid disposal or leaks into surface water bodies, comply with local environmental regulations.
Waste Treatment Methods: Dispose as hazardous pharmaceutical waste, use authorized chemical waste contractor
Container Disposal: Rinse triple, deface labels, recycle where appropriate, follow municipal guidelines
Environmental Precautions: Prevent contamination of soil and waterways during waste handling
Disposal Regulations: Comply with federal, state and local waste regulations
Special Precautions: Incineration may be used only in permitted facilities, avoid landfilling unless specifically designed for pharmaceutical wastes.
UN Number: Not classified under UN Dangerous Goods Codes
Transport Hazard Class: Not considered hazardous for road, rail, sea, or air transport under standard conditions
Packing Group: Not applicable
Proper Shipping Name: Pharmaceutical intermediate—non-hazardous
Special Precautions: Securely package to prevent dust emission, keep moisture-proof
Environmental Hazards: Avoid release during transport; notify authorities if accidental release into environment occurs.
Labeling Requirements: Product label must include chemical identity, hazard pictograms, safety precautions, emergency contacts
TSCA Status: Not listed
EC Classification: Xi (irritant), N (dangerous for the environment)
REACH Status: Safety data sheet available for professional use; complies with essential REACH safety data requirements for chemicals
OSHA Status: Not regulated as a specific hazardous chemical; handle as potentially harmful pharmaceutical substance
Other Regulations: Subject to national, state, and local health, safety, and environmental regulations governing pharmaceutical handling and disposal; check jurisdiction-specific requirements for medical, laboratory, and manufacturing use.
