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Product Name: Aztreonam Pure Powder
Other Names: Azactam, SQ 26,776
Chemical Family: Monobactam antibiotic
Molecular Formula: C13H17N5O8S2
Molecular Weight: 435.43 g/mol
Recommended Uses: Pharmaceutical research and manufacturing
Supplier Name: Refer to package label for contact
Emergency Phone: Local poison control or emergency response
GHS Classification: Eye irritation, Category 2A; Sensitization, respiratory Category 1; Skin sensitization Category 1
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms if inhaled, may cause an allergic skin reaction, causes serious eye irritation
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Wash hands thoroughly after handling, avoid breathing dust, wear protective gloves, clothing, and eye protection, use only outdoors or in well-ventilated area
Chemical Name: Aztreonam
Concentration: ~100%
CAS Number: 78110-38-0
Impurities/Additives: No significant impurities
Skin Contact: Remove contaminated clothing and rinse skin with water for at least 15 minutes; seek medical attention for irritation or allergic reaction
Eye Contact: Rinse cautiously with water for several minutes, lifting upper and lower eyelids; remove contact lenses if present and easy to do; continue rinsing; get medical attention
Inhalation: Move person to fresh air and keep comfortable; seek medical help if symptoms develop or persist
Ingestion: Rinse mouth, do not induce vomiting; get medical advice or attention immediately
Most Important Symptoms: Allergic reactions, respiratory discomfort, skin irritation, eye redness or swelling
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable Extinguishing Media: Do not use a heavy water stream
Specific Hazards: Powder can form airborne dust that may ignite under rare specialized conditions; hazardous decomposition products include oxides of carbon, nitrogen, sulfur
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Personal Precautions: Avoid formation of dust, ventilate area, avoid inhalation and contact with skin or eyes
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid release to the environment
Methods for Cleanup: Collect spilled powder by dampening it with suitable liquid to avoid dust, sweep up and place in suitable, properly labeled closed containers for disposal, wash area with water and detergent
Handling: Avoid breathing dust, avoid prolonged or repeated contact with skin; wear appropriate personal protective equipment and ensure local exhaust or general ventilation
Storage: Store in tightly closed containers in a cool, dry, and well-ventilated place away from incompatible materials such as strong oxidizers, acids, and bases; keep container tightly sealed and out of direct sunlight
Incompatible Materials: Strong oxidizing agents, reducing agents, acids, alkalis
Engineering Controls: Provide adequate ventilation, use local exhaust system to reduce airborne concentrations
Respiratory Protection: Use NIOSH-approved respirators for dust if exposure limits are exceeded
Skin Protection: Wear chemical-resistant gloves and protective clothing
Eye Protection: Use safety goggles or face shield
Work Practices: Do not eat, drink, or smoke in handling areas; wash hands thoroughly after handling
Appearance: White to off-white crystalline powder
Odor: No marked odor
Odor Threshold: Not available
pH: 4.5-7.5 (solution)
Melting Point/Freezing Point: Decomposes above 183°C
Boiling Point: Not applicable
Flash Point: Not applicable
Flammability: Not highly flammable as a solid powder
Vapor Pressure: Negligible
Density: Approximately 1.73 g/cm³
Solubility: Soluble in water
Partition Coefficient (n-octanol/water): Not available
Decomposition Temperature: >183°C
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not considered reactive under normal conditions of use
Hazardous Reactions: None expected under normal use
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides
Conditions to Avoid: Extreme heat, direct sunlight, high humidity
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Symptoms: Irritation to eyes, skin, and respiratory tract; allergic reactions such as rash or asthmatic symptoms
Chronic Effects: Sensitization, possible risk of subsequent allergic reactions with repeated exposure
LD50/LC50 Data: No data for pure compound; similar antibiotics suggest moderate toxicity
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No evidence of mutagenic potential in standard tests
Reproductive Toxicity: Not established
Aquatic Toxicity: May be harmful to aquatic life at high concentrations; no acute data for this compound, but pharmaceuticals are increasingly recognized as a risk factor for aquatic ecosystems
Persistence and Degradability: Slowly biodegradable; some resistance to microbial breakdown in the environment
Bioaccumulation Potential: Low
Mobility in Soil: Moderate mobility; may leach through soil
Other Adverse Effects: May disrupt natural bacterial populations if released
Waste Treatment Methods: Dispose of contents/container through a licensed hazardous waste disposal contractor; follow local, regional, national regulations
Unused Material: Handle as hazardous pharmaceutical waste
Contaminated Packaging: Rinse containers before recycling or disposal as hazardous waste
Avoid: Do not flush to surface water, sewer, or soil
UN Number: Not classified as dangerous for transport under current UN transport regulations
Proper Shipping Name: Not restricted
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Avoid releasing powder to air during transport, secure package against leaks and spills
OSHA Status: Not specifically regulated as a hazardous substance by OSHA
TSCA Inventory: Exempt as a pharmaceutical
REACH Status: Not registered
WHMIS Classification (Canada): Not classified
SARA Title III: Not listed as an extremely hazardous substance
California Proposition 65: No listed chemicals known to the state to cause cancer, birth defects, or other reproductive harm
Regulatory Notes: Pharmaceutical substances often require special handling and disposal according to local environmental and health regulations
