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Product Name: Avanafil Intermediate 3
Chemical Family: Organic Compound
Synonyms: Not available
CAS Number: Not assigned (specific to manufacturer batch)
Recommended Use: Pharmaceutical intermediate in Avanafil synthesis
Supplier: Manufacturer details available on request
Contact Information: Phone number and email provided by supplier
Emergency Telephone: Emergency hotline provided by regional authority
Classification: Potential irritant for skin, eyes, and respiratory tract
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation; may cause respiratory irritation
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Avoid inhalation, wash exposed skin thoroughly, wear eye and skin protection, handle in clean, well-ventilated areas
Other Hazards: No known chronic health effects; particle dust may aggravate pre-existing conditions
Chemical Name: Avanafil Intermediate 3
Concentration: >98% (remainder impurities)
Impurities: <2% synthesis byproducts (unclassified)
Molecular Formula: Reserved for company confidential data
Molecular Weight: Provided upon request
Chemical Abstracts Service Registry Number: Not registered
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical advice right away
Skin Contact: Wash thoroughly with soap and running water, remove contaminated clothing, consult a physician for irritation
Inhalation: Move person to fresh air, keep comfortable and seek medical help if symptoms like coughing or breathing difficulty persist
Ingestion: Rinse mouth, drink plenty of water, do not induce vomiting, get immediate medical attention
Most Important Symptoms: Irritation, burning sensation, redness
Notes for Physician: Treat symptomatically and monitor airway management
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Unsuitable Extinguishing Media: High volume water jet might spread material
Specific Hazards: Combustion may release toxic vapors such as carbon oxides, nitrogen oxides
Special Protective Equipment: Firefighters must use self-contained breathing apparatus and full protective gear
Firefighting Procedures: Keep run-off water contained, use non-sparking tools, evacuate area if necessary
Explosion Hazard: Dust explosion hazard possible if suspended in air
Personal Precautions: Avoid dust formation, use personal protective equipment, provide adequate ventilation
Environmental Precautions: Prevent entry into drains, sewers, soil, and water bodies
Methods for Clean-Up: Sweep up and collect in suitable containers for disposal, clean area with water, ventilate spill area
Emergency Procedures: Notify safety personnel, evacuate unnecessary personnel, refer to protective measures
Reference to Other Sections: Refer to sections on handling, exposure controls, and disposal
Precautions for Safe Handling: Use with proper ventilation, avoid dust, handle with gloves and goggles, prevent ingestion, do not eat or drink in work area
Conditions for Safe Storage: Keep container tightly closed in a cool, dry, well-ventilated place, protect from light and moisture
Storage Incompatibilities: Strong oxidizing agents, acids
Specific End Use: Only for use as intended as a chemical intermediate in manufacturing controlled environments
Storage Temperature: 2–8°C recommended, avoid temperature extremes
Occupational Exposure Limits: Not established by OSHA/ACGIH, minimize exposure as precaution
Engineering Controls: Mechanical ventilation, dust extraction, safety showers, eye wash stations
Personal Protective Equipment: Lab coat, chemical-resistant gloves, safety goggles, face shield for large-scale use
Respiratory Protection: NIOSH-certified mask or P2/P3 particulate respirator when dust forms
Environmental Exposure Controls: Prevent material release to the environment
Appearance: White to off-white powder
Odor: Slight, characteristic, not pungent
Odor Threshold: Not available
pH: Not applicable
Melting Point/Range: 110–125°C (typical, varies with batch)
Boiling Point/Range: Not readily vaporizable, decomposes before boiling
Flash Point: Not available, treat as combustible dust
Evaporation Rate: Negligible
Flammability: May form combustible dust clouds
Vapor Pressure: Negligible under normal conditions
Vapor Density: Not applicable
Relative Density: 1.20–1.32 (estimated)
Solubility: Low solubility in water, soluble in DMSO and some organic solvents
Partition Coefficient (n-octanol/water): Not measured
Auto-ignition Temperature: Not available
Decomposition Temperature: Decomposes above 150°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Low, does not react violently with common materials
Hazardous Reactions: Can react with oxidizing agents, acids can cause decomposition
Conditions to Avoid: Moisture, heat, direct sunlight, open flames
Incompatible Materials: Oxidants, acids
Hazardous Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides can form if burned
Routes of Entry: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Limited data; low acute toxicity expected, but irritant
Skin Contact: May cause moderate irritation, redness
Eye Contact: May cause burning, stinging, tearing
Inhalation: Dust can irritate throat and respiratory tract
Ingestion: May cause discomfort, consult physician
Chronic Effects: No reports on carcinogenicity or sensitization; protracted contact not advised
Target Organs: Skin, eyes, respiratory system
Other Effects: Not listed as a carcinogen or mutagen by IARC, NTP, or OSHA
Ecotoxicity: No aquatic toxicity data available, minimize environmental release
Persistence/Degradability: Expected to be slow to degrade under natural conditions
Bioaccumulation: Potential for bioaccumulation can’t be excluded due to lack of testing
Mobility in Soil: Low solubility suggests low mobility
Other Adverse Effects: Avoid discharge to the environment; toxic effects unlikely at low concentration
Disposal Methods: Dispose via licensed waste company, follow local, state, and federal environmental regulations
Contaminated Packaging: Clean before reuse or dispose as hazardous waste
Special Instructions: Material and packaging should not reach drains, surface water, or soil
Waste Codes: Check with regulatory agencies for applicable codes
UN Number: Not regulated for ground, air, or sea
Proper Shipping Name: Not classified as a dangerous good
Transport Hazard Class: Not applicable
Packing Group: Not mandated
Environmental Hazards: Not classified as marine pollutant
Additional Transport Precautions: Avoid mechanical shock, keep containers tightly sealed
U.S. Regulations: Not listed under SARA Title III, CERCLA, or California Prop 65
Europe: Not subject to REACH restrictions, not on SVHC list
Canada: Not on DSL or NDSL
Labeling: Comply with workplace labeling for hazardous substances
Other Regulations: Custom requirements for local jurisdiction may apply
