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Product Name: Atenolol
Chemical Name: 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
Synonyms: Tenormin, 4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}benzeneacetamide
CAS Number: 29122-68-7
Intended Use: Pharmaceutical ingredient, medicinal
Manufacturer Contact: Information supplied as per exporting party, including address and emergency phone
GHS Classification: Acute Toxicity (Oral) Category 4; Specific Target Organ Toxicity (Single Exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed; May cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust; Wash thoroughly after handling; If swallowed, seek medical attention
Key Symptoms: Headache, dizziness, fatigue, mild bradycardia, hypotension
Target Organs: Heart, cardiovascular system
Chemical: Atenolol
CAS Number: 29122-68-7
Content: >98% pure
Impurities: Trace-level process-related impurities below regulatory thresholds
Mixture Information: No relevant hazardous excipients included in raw drug substance
Eye Contact: Rinse with plenty of water for 10–15 minutes, seek medical advice if irritation persists
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing
Inhalation: Move to fresh air, monitor breathing, obtain medical attention if symptoms persist
Ingestion: Seek immediate medical advice, do not induce vomiting unless directed by a medical professional
Most Important Symptoms: Acute ingestion may depress cardiovascular function, medical monitoring needed
General Guidance: Provide this sheet to attending physician
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: High volume water jet
Special Hazards: Emits toxic fumes including nitrogen oxides and carbon oxides under fire conditions
Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Special Procedures: Avoid breathing smoke, stay upwind, remove containers from danger area if safe
Personal Precautions: Wear respirator, gloves, eye and face protection
Environmental Precautions: Prevent product from entering drains, waterways, or soil
Clean-Up Procedures: Sweep up without raising dust, transfer to labeled waste container, ventilate area, wash spill site
Disposal: Dispose according to regulatory requirements for pharmaceutical substances
Precautions for Handling: Avoid contact with eyes, skin, and clothing; avoid inhalation of powder or dust
Technical Measures: Work in well-ventilated area, use local exhaust if available
Fire Measures: Keep away from ignition sources, no smoking
Storage Conditions: Store in tightly sealed original container, cool, dry, well-ventilated place, protect from light
Incompatibilities: Keep away from oxidizing agents and strong acids
Shelf Life: Refer to manufacturer’s expiry information
Engineering Controls: Work with adequate local ventilation, containment may be needed for large batches
Respiratory Protection: Use approved respirator in absence of adequate ventilation
Skin Protection: Use chemical-resistant gloves, lab coat or protective clothing
Eye/Face Protection: Safety goggles compliant with EN166 or ANSI Z87 standards
Hygiene Measures: Do not eat, drink or smoke during handling, wash hands before breaks and after work
Exposure Limits: No established occupational exposure limits for atenolol yet, treat as pharmaceutical active
Appearance: White or almost white crystalline powder
Odor: Odorless
Melting Point: 152–155°C
Solubility: Slightly soluble in water, practically insoluble in acetone and alcohol
pH: Neutral (5.0–7.0, 1% solution)
Molecular Formula: C14H22N2O3
Molecular Weight: 266.34 g/mol
Partition Coefficient (log Pow): -0.02
Vapor Pressure: Not applicable
Flash Point: Not determined
Bulk Density: 0.3–0.5 g/cm³
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Moisture, excessive heat, prolonged exposure to light
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition: Carbon monoxide, carbon dioxide, nitrogen oxides may form
Polymerization: Not reported under normal conditions
Acute Toxicity: Estimated oral LD50 (rat): 2000 – 4000 mg/kg
Chronic Effects: Target organ effects on the heart, prolonged bradycardia at clinically significant exposures
Irritation: May cause mild irritation upon contact with eyes or skin
Sensitization: No expected skin sensitization from current evidence
Mutagenicity: No observed genotoxic effects in standard battery of tests
Carcinogenicity: Not classified as a human carcinogen by IARC, NTP, ACGIH or OSHA
Reproductive Toxicity: Studies in animals do not show teratogenic effects at human therapeutic doses
Symptoms of Exposure: Bradycardia, hypotension, dizziness, cold extremities
Ecotoxicity: Harmful to aquatic organisms at high concentrations, chronic exposure could affect aquatic life
Mobility: Low to moderate mobility in soil predicted
Persistence/Degradability: Not readily biodegradable, may persist in environment
Bioaccumulation: Log Pow below 1 suggests low potential for bioaccumulation
Other Adverse Effects: Uncontrolled release may threaten local waters and organisms
Waste Disposal: Incinerate in controlled environment or send to authorized treatment facility
Container Disposal: Ensure complete emptying, triple rinse if necessary, follow country-specific hazardous waste guidelines
Physical/Chemical Properties Affecting Disposal: Non-volatile, incineration with afterburner and effluent gas scrubbing recommended
Ecological Do’s/Don'ts: Do not discharge to surface waters, sewers, or soil
UN Number: Not classified as hazardous for transport under UN criteria
Proper Shipping Name: Atenolol, not regulated
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Special Precautions: Avoid damage to packaging, prevent spillage during transport
Marine Pollutant: Not identified as marine pollutant yet, but measures should prevent entry to waterways
Regulatory Status: Active pharmaceutical ingredient with local and international regulation for manufacture and export
GHS Labeling: Classified for health hazard, labeling required in exported regions
Inventory Status: Listed in major chemical inventories under pharmaceutical category
Other Requirements: Registration with national drug authorities, compliance with ICH/Q7 GMP guidelines for APIs
Worker Protection: Measures to comply with health and safety rules, training in handling hazardous drugs
