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Product Name: Arbidol Hydrochloride
Chemical Name: Ethyl-6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-indole-3-carboxylate hydrochloride
Synonyms: Umifenovir hydrochloride
CAS Number: 131707-25-0
Recommended Use: Antiviral pharmaceutical ingredient
Manufacturer: Supplied according to purchase order documentation
Emergency Contact: Refer to local poison control center or emergency health service for immediate assistance
UN Number: Not classified for transport under standard chemical regulations
GHS Classification: May cause respiratory and skin irritation; may cause eye irritation; not classified as flammable or combustible
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: May cause mild skin and eye irritation, respiratory tract irritation
Precautionary Statements: Avoid breathing dust, avoid contact with skin and eyes, wash thoroughly after handling
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Symptoms: Mild irritation to skin, eyes, and respiratory system
Other Hazards: No direct evidence of carcinogenicity or mutagenicity in standard hazard screenings; long-term toxicity data remains limited
Ingredient: Arbidol Hydrochloride
Chemical Formula: C22H25BrN2O3S•HCl
Concentration: Approximately 99%
Impurities: Trace solvent residues (<0.1%), process-related organic impurities (<0.5%)
Other Components: None reported in API form
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; seek medical attention if irritation persists
Skin Contact: Wash area with soap and plenty of water; remove contaminated clothing and launder before reuse; get medical attention for persistent redness or discomfort
Inhalation: Move affected person to fresh air; provide oxygen if breathing is difficult; consult a physician
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical help right away
Most Important Symptoms: Mild irritation, possible allergic reaction; rarely more severe systemic toxicity
Note to Physicians: Treat symptomatically based on patient presentation and clinical judgment
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide for small fires
Specific Hazards: Decomposition may release toxic fumes of hydrogen chloride, nitrogen oxides, sulfur oxides, bromine-containing compounds
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Fire-Fighting Precautions: Prevent runoff from entering waterways or drains; cool containers with water spray
Unusual Fire Hazards: Fine powder may present a dust explosion hazard in confined situations, minimize dust generation
Personal Precautions: Use personal protective equipment including gloves, goggles, protective clothing, and an approved dust mask
Environmental Precautions: Prevent spillage from entering drains or watercourses; contain spill as much as possible
Cleanup Methods: Sweep up and place in a suitable, properly labeled waste disposal container; clean affected area with detergent and water; ventilate area thoroughly
Other Measures: Avoid raising dust during cleanup; wash exposed skin after handling
Handling: Use only in well-ventilated areas; avoid inhaling dust; avoid contact with skin and eyes; keep away from food and beverages
Storage Conditions: Store in a tightly sealed original container; protect from light, moisture, and extreme temperature changes; recommended storage temperature ranges from 2 to 8°C
Incompatible Materials: Strong acids, strong bases, strong oxidizing agents
Safe Storage Advice: Keep container in a secure, dry area with restricted access; ensure labeling remains visible and legible
Exposure Limits: No occupational exposure limits established
Engineering Controls: Handle in fume hood or area with effective local exhaust; use dust extraction if available
Personal Protection: Wear chemical-resistant gloves, safety goggles, and laboratory coat. Respiratory protection with N95 or P2 particle-filtering mask for airborne particles
Hygienic Practices: Wash hands before breaks and after handling; do not eat, drink, or smoke around substance
Environmental Controls: Prevent formation of airborne dust; install spill control equipment close to work area
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: 3 to 5 (1% solution in water)
Melting Point: 167–171°C
Boiling Point: Not available (decomposes before boiling)
Solubility: Slightly soluble in water, soluble in dimethyl sulfoxide, methanol, ethanol, acetonitrile
Vapor Pressure: Negligible at ambient temperature
Density: Approximately 1.4 g/cm³
Partition Coefficient (log Pow): Estimated 3.1 (octanol/water)
Flash Point: Not flammable under normal conditions
Explosive Properties: No data to indicate explosive risk
Other Data: Stable under recommended conditions, forms dust easily when handled improperly
Chemical Stability: Stable under normal storage and handling conditions
Stability Data: Sensitive to moisture, prolonged exposure to air can result in mild hydrolysis
Incompatibilities: Strong acids, strong bases, oxidizers; may decompose in presence of ultraviolet light
Decomposition Products: Hydrogen chloride, nitrogen oxides, sulfur oxides, bromine compounds, carbon monoxide, carbon dioxide
Polymerization: Will not occur
Likely Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity Data: Rat oral LD50 > 3,200 mg/kg; exact human toxicity not fully characterized
Skin Corrosion/Irritation: May cause mild irritation in sensitive individuals
Eye Damage/Irritation: Slight and reversible irritation possible
Respiratory Sensitization: Dust can irritate upper respiratory tract
Chronic Effects: No confirmed long-term toxicity identified in non-clinical studies at normal handling levels
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Reproductive Toxicity: Available data suggests low risk at pharmaceutical dose levels
Other Health Effects: No significant systemic toxicity documented at occupational exposure levels
Aquatic Toxicity: Not expected to present significant hazard to aquatic organisms at low concentrations; no detailed data available
Persistence and Degradability: Degrades slowly in soil and water; stable under most environmental conditions; not readily biodegradable
Bioaccumulative Potential: Low to moderate risk due to partition coefficient data; environmental accumulation unlikely at routine emission rates
Mobility in Soil: Limited mobility due to relative insolubility in water
Other Adverse Effects: Not known to be acutely or chronically hazardous to environmental organisms based on current use patterns
Waste Disposal Methods: Collect contaminated material, unused substance, and clean-up waste into a sealed container; send for incineration in a licensed chemical waste facility
Container Disposal: Rinse packaging, puncture to prevent reuse, dispose of per local and national hazardous waste protocols
Special Precautions: Avoid release into the environment, do not pour into drains, watercourses, or household waste
Regulatory Requirements: Comply with all federal, state, and local regulations for chemical waste disposal
UN Number: Not regulated for ground, air, or sea transport
Proper Shipping Name: Not hazardous for shipping purposes
Hazard Class: Not assigned
Packing Group: Not applicable
Labels Required: No dangerous goods labeling required
Special Precautions: Protect from physical damage and moisture during transport; maintain good packaging integrity
Labeling Under GHS: Warning, may cause mild skin and eye irritation
Inventory Listings: Registered or exempted in main international chemical inventories; refer to supplier for national compliance
OSHA Hazards: Irritant
California Proposition 65: Not listed
Other Regulations: Not classified as a controlled or restricted substance; pharmaceutical use subject to national medicines regulations; environmental release may fall under local environmental protection laws
