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Product Name: Apramycin Sulfate
Chemical Formula: C21H41N5O11·H2SO4
Common Synonyms: Apralan, Apramycin monosulfate
Recommended Use: Veterinary antibiotic
Manufacturer: Refer to packaging for manufacturer details
Contact Information: Company emergency contact number on shipping documents
CAS Number: 65710-07-8
UN Number: Not assigned
Emergency Procedures: Refer to on-site protocol and follow instructions provided by responsible personnel
Date of Issue: Check supplier documentation for versioning and updates
GHS Classification: Harmful if swallowed, may cause allergic skin reaction, potential respiratory irritant
Label Elements: Exclamation mark, health hazard icon
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Potential Health Effects: Respiratory irritation, skin sensitization, gastrointestinal discomfort, allergic reactions in susceptible individuals
Physical Hazards: Dust can cause irritation to eyes and upper respiratory tract
Environmental Hazards: Can be harmful to aquatic life with long lasting effects
Precautionary Statements: Avoid dust generation, avoid breathing dust, wash hands thoroughly after handling, wear protective clothing and gloves
Signal Word: Warning
Chemical Name: Apramycin Sulfate
CAS Number: 65710-07-8
Concentration: Typically >95% active ingredient
Impurities: Trace organic byproducts less than 1%
Form: Powder (free flowing, off-white to yellowish)
Mixtures: Not present (substance in pure form)
Inhalation: Remove to fresh air, seek medical attention if symptoms like shortness of breath or coughing persist
Skin Contact: Immediately wash with soap and water, remove contaminated clothing, seek medical guidance for persistent irritation
Eye Contact: Flush cautiously with water for at least 15 minutes, lift eyelids occasionally, seek medical care if irritation remains
Ingestion: Rinse mouth, do not induce vomiting, get medical help if large quantity swallowed or symptoms develop
Most Important Symptoms: Allergic reactions, breathlessness, irritation, rash on exposed skin
Advice to Medical Staff: Symptomatic treatment based on observed signs and patient complaints
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, alcohol-resistant foam
Unsuitable Media: Do not use a direct water jet that may spread dust
Special Hazards: Toxic fumes (carbon oxides, nitrogen oxides, sulfur oxides) may form
Protective Equipment: Self-contained breathing apparatus, full protective gear
Special Procedures: Move undamaged containers from fire area if safe, use water spray to cool exposed surfaces
Prevent Fire Spread: Avoid allowing fire run-off to enter drains or watercourses
Personal Precautions: Wear protective gloves, goggles, dust mask or respirator, avoid direct contact
Environmental Precautions: Prevent entry into sewers, soil, waterways
Clean-up Method: Sweep up with care, avoid dust creation, place into sealed labeled containers for safe disposal
Decontamination: Wash spillage site after clean-up
Advice for Emergency Responders: Refer to protective measures under Exposure Controls and Personal Protection section
Safe Handling: Minimize dust formation, avoid inhalation or direct skin/eye contact, employ good housekeeping practices
Personal Hygiene: Wash thoroughly after handling, do not eat or drink while working with product
Storage Conditions: Keep in tightly closed, labeled containers in a cool, dry, well-ventilated location
Incompatible Materials: Strong oxidizers, acids, alkalis
Storage Area: Secure area with restricted access, keep away from food and feedstuffs
Special Precautions: Store away from moisture and direct sunlight
Engineering Controls: Use local exhaust ventilation, enclose processing systems to minimize airborne dust
Occupational Exposure Limits: No specific limits set, follow general dust standards <10 mg/m³
Personal Protection:
Respiratory Protection: NIOSH-approved dust mask or equivalent
Hand Protection: Rubber or nitrile gloves
Eye/Face Protection: Safety goggles or face shield
Body Protection: Long-sleeved garment, apron if risk of spill or splash exists
Environmental Controls: Prevent product release to environment
Appearance: Off-white to pale yellow crystalline powder
Odor: Nearly odorless
pH: 4.0 - 7.0 (1% aqueous solution)
Melting Point: Decomposition before melting, not determined
Boiling Point: Not applicable for solid
Solubility: Freely soluble in water, practically insoluble in organic solvents
Vapor Pressure: Not significant at ambient temperature
Relative Density: Approximately 1.6 g/cm³
Flash Point: Not applicable
Flammability: Not considered highly flammable but may form combustible dust clouds
Explosive Properties: Dust explosion hazard in finely divided form under certain conditions
Partition Coefficient: No data available
Chemical Stability: Stable under normal shipping and storage conditions
Conditions to Avoid: Exposure to excessive heat, moisture, strong light
Incompatible Materials: Strong oxidizers, acids, alkalis, moisture
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides under fire or extreme heat
Reactivity: No dangerous reactions expected under normal use
Acute Toxicity: Oral LD50 (rat): 3000-4000 mg/kg
Chronic Effects: Potential for kidney toxicity after prolonged exposure, risk of allergy development in sensitive persons
Skin Corrosion/Irritation: Minor irritation possible, may lead to sensitization
Respiratory Sensitization: May cause respiratory discomfort or allergic response in some workers
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: Limited evidence, generally not considered mutagenic
Reproductive Toxicity: No specific data for adverse reproductive effects
Symptoms of Exposure: Rash, eye redness, itching, cough, wheezing, nausea
Aquatic Toxicity: Harmful to aquatic organisms, may cause long lasting effects in water bodies
Soil Mobility: Moderate mobility in soils, risk for groundwater contamination with repeated or large-scale use
Persistence and Degradability: Degradability depends on environmental conditions, may persist in some settings
Bioaccumulative Potential: Low, but impacts on non-target organisms possible
Further Information: Follow best management practice to limit environmental release
Disposal Methods: Dispose of unused material via licensed chemical waste contractor, following local, regional, and national regulations
Contaminated Packaging: Rinse and dispose of empty containers as hazardous chemical waste
Environmental Precautions: Do not discharge into drains, surface waters, or soil
Special Considerations: Consult specialist disposal service if unsure of correct disposal method
UN Number: Not regulated for transport
Proper Shipping Name: Pharmaceutical intermediate–Apramycin Sulfate
Transport Hazard Class: Not assigned
Packing Group: Not required
Special Precautions: Keep in tightly sealed packaging, protect from physical damage and moisture
Environmental Hazards: Not classified as marine pollutant
Additional Transport Notes: Ship in accordance with national and international guidelines to prevent accidental release
TSCA Inventory: Not listed for pharmaceutical use
EU REACH: Exempt as veterinary medicinal product
OSHA Status: Regulated as hazardous dust
WHMIS Classification: D2B — Toxic material causing other toxic effects
Other Regulations: Classified according to country-specific regulations (consult local requirements)
Labeling: Warning statement about dust and allergic responses required
