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Product Name: Andrographolide
Chemical Formula: C20H30O5
Synonyms: 3α,14,15,18-Tetrahydroxy-5β,9βH,10α-labda-8,12-dien-16-oic acid δ-lactone
CAS Number: 5508-58-7
Intended Use: Used in pharmaceutical, nutraceutical research, often for extraction and purification in laboratories, sometimes as a reference standard.
Manufacturer/Supplier: Scientific supply companies, botanical extract manufacturers, custom synthesis labs offering research-grade materials.
Contact Details: Company emergency phone numbers and addresses can usually be found on official invoices and product labels.
Emergency Phone: Poison control centers or local emergency services accessible 24 hours for chemical exposure incidents.
Classification: Irritant for eyes, skin, and respiratory tract, may cause allergic reactions or respiratory discomfort if inhaled, generally presents a low acute toxicity profile.
Signal Word: Warning
Hazard Statements: May irritate mucous membranes, eyes, and skin upon direct contact; dust formation causes risk of inhalation; no evidence of carcinogenic or teratogenic potential at typical laboratory concentrations.
Pictograms: Standard GHS exclamation mark icon, indicative of skin/eye/respiratory irritant.
Precautionary Statements: Avoid all unnecessary exposure, use protective equipment, do not breathe dust, wash hands thoroughly after handling, dispose of contaminated materials properly.
Main Ingredient: Andrographolide—purity ≥98% in research-grade samples.
Impurities: Minor quantities of related diterpenoid lactones if sourcing from botanical extracts; potential for residual solvents if isolation not thorough; carriers or excipients negligible or absent in pure form.
Hazardous Components: No classified hazardous impurities or additives in typical research applications, but always check certificates of analysis.
Physical Form: White to off-white crystalline powder.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, keeping eyelids open; seek medical attention if irritation or redness persists.
Skin Contact: Remove contaminated clothing instantly; wash skin thoroughly with soap and running water for at least 10 minutes; monitor for sensitization or rash.
Inhalation: Move exposed person to fresh air immediately; allow rest in a semi-upright posture; contact physician if any symptoms develop or if nervous system symptoms show.
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical attention and provide product label or MSDS.
Most Important Symptoms:** Rash, redness, respiratory tract irritation, possible headache or dizziness from dust inhalation.
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide or water spray as appropriate for surrounding fire; do not use water jet directly on burning product if powdered form.
Specific Hazards: Fumes contain oxides of carbon or potentially noxious organic vapors; decomposition above 200°C releases acrid smoke.
Protective Equipment: Firefighters wear self-contained breathing apparatus, gloves, chemical-resistant clothing; avoid inhalation of decomposition products.
Advice: Remove all containers from area at risk if safe; prevent fire run-off from entering drains or watercourses.
Personal Precautions: Use dust mask or respirator, eye protection, gloves; prevent inhalation and skin contact; ensure adequate ventilation.
Environmental Precautions: Prevent further leakage or spillage if safe to do so; do not allow to enter soil, sewers, or waterways.
Cleanup Methods: Sweep or vacuum up spilled solid with non-sparking tools; avoid raising dust clouds; transfer to dry labeled containers for safe disposal.
Decontamination: Clean affected surfaces with appropriate cleaning solution, rinse with water, ventilate area to remove dust or vapors.
Precautions for Handling: Handle in well-ventilated settings, avoid creating airborne dust, employ appropriate PPE including gloves, goggles, and lab coat.
Safe Storage Conditions: Store tightly closed in original container in a cool, dry location away from light, oxidizers, and incompatible substances; keep away from ignition sources and moisture.
Incompatibilities: Avoid storing near strong acids, bases, or oxidizing agents.
Hygiene Measures: Wash hands after every handling session, do not eat, drink, or smoke in the handling area; keep storage area clearly labeled and restricted to trained personnel.
Exposure Limits: No established occupational exposure limits for this compound, but minimize dust inhalation and repeated skin contact.
Engineering Controls: Use chemical fume hoods, local exhaust ventilation, or dust extraction systems.
Eye/Face Protection: Chemical safety goggles with side shields.
Skin Protection: Wear nitrile or latex gloves, laboratory coat or disposable coveralls.
Respiratory Protection: Dust mask or particulate respirator (N95, P2, or equivalent) where ventilation insufficient.
Environmental Exposure Controls: Avoid release to the environment; collect and dispose of waste according to regulations.
Appearance: White to pale yellow crystalline powder.
Odor: Mild, slightly bitter, herbal aroma.
Molecular Weight: 350.45 g/mol
Melting Point: 230–235°C
Solubility: Moderately soluble in methanol, ethanol, DMSO; slightly soluble in water; insoluble in non-polar solvents.
Boiling Point: Decomposes before boiling.
Vapor Pressure: Not applicable under standard conditions.
pH: No data for dry powder; solutions slightly acidic to neutral depending on solvent.
Partition Coefficient (Log Kow): Estimated around 2.3.
Flash Point: No reliable data for solid form.
Chemical Stability: Stable under normal conditions of storage and use when protected from moisture, heat, and light.
Hazardous Reactions: Reacts with strong oxidizing agents, vigorous exothermic reaction possible on direct heating or ignition.
Decomposition Products: Combustion or extreme heating releases carbon monoxide, carbon dioxide, possibly unidentified organic compounds.
Conditions to Avoid: Exposure to strong heat, open flame, moisture, strong acids, or bases.
Polymerization: No known risk of hazardous polymerization.
Acute Toxicity: Low acute oral and dermal toxicity; rodents (rats, mice) exhibit minimal symptoms at high doses.
Skin/Eye Irritation: Mild skin and eye irritation observed, particularly with prolonged exposure.
Respiratory Sensitization: Dust inhalation can irritate upper airways, provoke coughing or discomfort.
Chronic Toxicity: No long-term studies showing carcinogenicity or teratogenicity at normal exposure levels.
Other Effects: Large oral or intravenous doses in animals sometimes produce gastrointestinal upset; not mutagenic or clastogenic in established test systems.
Ecotoxicity: Low aquatic toxicity, rapid breakdown expected in soil, very limited data on bioaccumulation or persistent presence in food chain.
Degradability: Expected to degrade under normal environmental conditions, not classified as persistent organic pollutant.
Mobility: Low mobility in soil; not likely to leach into groundwater.
Bioaccumulation: Negligible risk based on lipophilicity and degradation profile.
Aquatic Environment: Avoid uncontrolled release into streams, sewers, or drinking water sources.
Product Disposal: Small amounts dispose of as chemical waste via approved disposal company; large volumes coordinate with hazardous waste management services.
Container Disposal: Rinse empty containers thoroughly, remove labels, dispose of through chemical waste management or return to supplier.
Precautions: Do not discharge into drains; avoid contamination of surface, groundwater, or soil.
Regulatory Compliance: Adhere to disposal requirements as per local, regional, and national regulations, including hazardous waste codes.
UN Number: Not classified as dangerous goods for transport by air, land, or sea.
Proper Shipping Name: Chemical for laboratory use—in original, sealed, and labeled packaging.
Transport Hazard Class: None assigned.
Packing Group: None.
Special Precautions: Protect containers from moisture, seal tight, avoid excessive vibration or mechanical shock; keep separate from reactive chemicals.
Labeling: Mark as “not restricted,” ensure all transit documentation is complete.
Environmental Hazards: Not considered marine pollutant or “dangerous for the environment” as per UN or IATA rules.
Labeling Requirements: Product labels must include product name, CAS number, hazard pictograms, supplier information, batch number, and emergency contact details.
GHS Classification: Not classified as hazardous substance under GHS based on typical laboratory quantities, but precautionary language required for irritancy.
TSCA Status (USA): Typically available for research and development; specific supplier may need to confirm regulatory listing.
REACH Status (EU): May be exempt for R&D quantities; full registration not always necessary, check import limits.
Other Local Requirements: Maintain inventory logs, provide safety training to all handlers, notify local authorities if exceeding storage thresholds or during accidental release.
Workplace Regulations: OSHA, WHMIS, and other national frameworks demand proper workplace labeling, documentation, and access to MSDS for all users.
