© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Amoxicillin Trihydrate
Chemical Name: (2S,5R,6R)-6-[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
Synonyms: Amoxil, Trimox
CAS Number: 61336-70-7
Recommended Uses: Pharmaceutical API, laboratory use, research applications
Supplier Details: Information required from packaging or responsible distributor
Emergency Contact: Company emergency response line or local poison center
Classification: Eye irritant (Category 2A), Respiratory sensitizer (Category 1), Skin sensitizer (Category 1)
Label Elements: Pictogram for exclamation point, health hazard symbol
Signal Word: Warning
Hazard Statements: May cause allergic skin or respiratory reaction. Causes moderate eye irritation. Avoid dust formation. May aggravate asthma, eczema, or existing allergies.
Precautionary: Avoid inhalation. Wash exposed area after handling. Wear gloves and eye protection.
Chemical Identity: Amoxicillin Trihydrate
Concentration: 97-100%
Impurities: Trace levels of related penicillin derivatives
Molecular Weight: 419.45 g/mol
Molecular Formula: C16H19N3O5S•3H2O
Inhalation: Remove individual to fresh air. Seek medical authority if respiratory irritation, wheezing, or allergic signs develop.
Skin Contact: Wash with soap and plenty of water. Remove contaminated clothing. Obtain medical help if rash or irritation persists.
Eye Contact: Rinse carefully with water for at least 15 minutes. Remove contact lenses. Prompt medical evaluation is recommended for ongoing irritation.
Ingestion: Rinse mouth with water. If large quantities have been swallowed, consult health professional immediately.
Acute Reactions: For signs of anaphylaxis (difficulty breathing, swelling), call emergency services right away.
Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Hazards from Product: During combustion, produces carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides
Protective Equipment: Standard firefighting gear with self-contained breathing apparatus
Firefighting Guidance: Move containers from fire area if safe. Avoid inhaling fumes. Control runoff to prevent environmental contamination.
Explosion Risk: Not classed as an explosion hazard in dust or solid form but minimize dust generation.
Personal Precautions: Prevent dust, ventilate area, protect skin and eyes
Spill Containment: Collect powder without creating dust cloud using wet mop or vacuum equipped with HEPA filter
Cleanup Methods: Wipe area with damp cloths after bulk is removed. Dispose of contaminated material appropriately.
Environmental Precautions: Do not release to surface waters, drains, or environment without treatment. Prevent further leakage if safe.
Precautions: Open containers in well-ventilated places. Avoid breathing dust, and prolonged or repeated exposure.
Protection: Use protective gear such as gloves and goggles, especially in bulk handling or production settings.
Safe Storage: Store tightly closed, away from light and moisture, under controlled temperature of 15-30°C. Store separately from strong acids or oxidizers.
Special Storage Needs: Keep in original packaging, labeled with hazard precautions and batch information.
Exposure Limits: No established OSHA/ACGIH standards. Treat exposure as for pharmaceutical active ingredients.
Engineering Controls: Ventilation, fume hoods, dust control. Work in designated areas with containment systems if possible.
Personal Protection: Use chemical-resistant gloves, safety glasses, laboratory coat, and respirator for dust. Wash hands thoroughly after use.
Environmental Protection: Efficient air filtration or extraction for dusts and vapors. Regular workplace monitoring for airborne concentration suggested.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint medicinal
Solubility: Slightly soluble in water; soluble in dilute acids
pH (solution): About 4.0 to 7.0 (in 10 mg/ml solution)
Melting Point: Decomposes above 200°C
Boiling Point: Not applicable (decomposes on heating)
Vapor Pressure: Not volatile
Partition Coefficient: Log P (octanol/water) -1.5 (approximate)
Other: Stable under recommended storage; avoid excessive moisture and heat to keep potent.
Chemical Stability: Stable at room temperature in closed containers
Reaction Conditions: Hydrolyzes and loses activity in strong acid, alkali, or high humidity
Incompatible Materials: Strong acids, oxidizing agents, strong bases
Hazardous Decomposition: Burning releases nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide
Polymerization: Will not occur
Degradation: Degrades with moisture and high temperature exposure.
Acute Toxicity: LD50 (oral, rat) above 5,000 mg/kg
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Effects: May cause allergic reaction, respiratory symptoms, rash, or gastrointestinal upset. Reports of hypersensitivity and anaphylaxis after exposure.
Chronic Effects: Allergic sensitization possible with repeated contact. Underlying asthma or allergies can worsen after exposure.
Carcinogenicity: No evidence for carcinogenic effects in studies. Not on IARC, NTP, or OSHA carcinogen lists.
Environmental Fate: Not readily biodegradable. Can persist in soil and water if released untreated.
Ecotoxicity: Low acute toxicity to fish and aquatic organisms (LC50 > 100 mg/L in many species). Biological activity in environment may impact microbial communities.
Bioaccumulation: Unlikely due to high water solubility.
Other Concerns: Potential impact on wastewater treatment due to antibiotic-resistant bacteria selection.
Waste Handling: Dispose of in accordance with local, regional, or national regulations as pharmaceutical waste.
Container Disposal: Rinse and render packaging unusable before landfill or incineration as per pharmaceutical product regulations.
Precaution: Do not allow material to enter surface water, sewer, or garbage destined for untreated landfill. Avoid material handling by those with penicillin allergies.
UN Number: Not classified under UN hazardous materials
Proper Shipping Name: Amoxicillin Trihydrate
Transport Hazard Class: Not applicable
Packing Group: Not regulated
Special Precautions: Keep container tightly sealed and protected from physical damage and moisture during transit.
US Regulations: Not listed as hazardous by OSHA or CERCLA; regulated as a prescription drug; SARA Title III not applicable
EU Regulations: Classified according to EC No. 1272/2008 (CLP): irritant, sensitizer
WHMIS Classification (Canada): D2B (Toxic - skin and eye irritant)
Other Regulatory: Handle in compliance with local, national, and international pharmaceutical and environmental regulations.
