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Product Name: Amoxicillin Sodium
Chemical Formula: C16H18N3NaO5S
Synonyms: Amoxil sodium salt, Amoxycillin sodium
CAS Number: 34642-77-8
Intended Use: Laboratory chemical, Chemical reagent
Supplier: Chemical distributor or laboratory supplier specializing in pharmaceuticals
GHS Classification: Skin sensitization (Category 1), Eye irritation (Category 2A), Specific target organ toxicity (single exposure, Category 3)
Label Elements: Signal word: Warning; Hazard statements: May cause allergic skin reaction, Causes serious eye irritation, May cause respiratory irritation
Other Hazards: Exposure may trigger symptoms in individuals with penicillin allergies. Dust formation may cause respiratory tract irritation. Rapid response needed for any signs of anaphylaxis or severe allergy, even at first contact.
Chemical Name: Amoxicillin Sodium
Concentration: ≥ 98% (by assay)
Impurities: Mainly residuals from synthesis, usually ≤ 2%, including possible penicilloic acids
Molecular Weight: 387.4 g/mol
Physical Form: White to off-white crystalline powder
Inhalation: Take the affected person to fresh air, monitor for trouble breathing, provide oxygen or artificial respiration if needed, seek medical help quickly
Skin Contact: Remove contaminated clothing, flush skin thoroughly with water and mild soap, watch for allergic reaction such as rash or swelling
Eye Contact: Rinse eyes immediately for at least 15 minutes under running water, lift eyelids occasionally, obtain medical attention for persistent irritation
Ingestion: Rinse mouth thoroughly, do not induce vomiting, drink water only if conscious, get medical attention due to risk of allergy
General Notes: Immediate attention required for anyone with a history of hypersensitivity to beta-lactam antibiotics
Suitable Extinguishing Media: Water spray, carbon dioxide, foam, or dry chemical
Unsuitable Extinguishing Media: High-pressure water jets spread powder
Specific Hazards: Decomposes under fire conditions, releasing irritating fumes, possibly nitrogen oxides, sulfur oxides
Protective Equipment: Full protective gear and self-contained breathing apparatus recommended for firefighters due to risk of toxic gases
Advice for Firefighters: Approach from upwind, avoid inhalation of combustion products, contain runoff water to prevent groundwater contamination
Personal Precautions: Wear lab coat, gloves, and eye protection, use dust mask in poorly ventilated areas
Environmental Precautions: Avoid entry into drains, soil, or surface water because antibiotics disrupt microbial ecology
Cleanup Methods: Sweep up without generating dust, collect material in sealed containers for disposal, use wet methods if possible for final cleaning
Spill Size Response: Limit area access, ventilate room, and decontaminate surfaces after removal
Advice on Safe Handling: Use personal protection at all times, avoid skin contact, do not inhale dust, prevent formation of airborne particles
Storage Conditions: Store in a tightly closed container, keep in a cool, dry place (2-8°C) away from heat sources
Incompatibilities: Strong oxidizers, strong acids or bases, and moisture — contact triggers decomposition or reduces stability
Handling Practices: Avoid accumulation of dust, use appropriate ventilation, and maintain good hygiene standards around work area
Occupational Exposure Limits: No established limits, minimize exposure by workplace control measures
Engineering Controls: Work inside a chemical fume hood, apply local exhaust ventilation to control dust
Personal Protection: Laboratory latex or nitrile gloves, safety goggles, disposable lab coats or coveralls, dust mask or certified respirator where airborne levels may be significant
Hygiene Measures: Wash hands after handling, remove contaminated clothing before leaving the lab, do not eat or smoke in the work area
Appearance: White or slightly yellow powder
Odor: Odorless or faintly medicinal
Solubility: Freely soluble in water, practically insoluble in organic solvents
pH (1% solution): About 8–10
Melting Point: Decomposes above 190°C without a clear melting point
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible at room temperature
Other Data: Stable under recommended conditions, but moisture and light accelerate degradation
Chemical Stability: Stable under dry, cool conditions; degrades in presence of moisture or excessive heat
Reactivity: Reacts with acids, bases, and oxidizing agents
Hazardous Decomposition: Produces toxic nitrogen and sulfur oxides during burning or heating
Conditions to Avoid: Exposure to heat, humidity, contact with incompatible substances
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity: LD50 (oral, rat) estimated at 6600 mg/kg
Skin and Eye Irritation: Causes irritation, allergic reactions possible especially in sensitive individuals
Sensitization: Confirmed reports of allergic and anaphylactic reactions in users with penicillin/cephalosporin allergies
Long-term Effects: Prolonged exposure may disrupt normal gut flora, cause skin rashes, or trigger asthmatic responses
Other Effects: Rapid medical intervention required for anaphylaxis following contact or ingestion
Toxicity to Aquatic Life: Harmful to aquatic microorganisms, alters bacterial populations, potential for antibiotic resistance spread
Persistence and Degradability: Biodegrades slowly in the environment, breakdown influenced by sunlight, temperature, and microbial action
Bioaccumulation: Little evidence for bioaccumulation, but persistent in water and soil
Other Considerations: Even trace environmental contamination can shift microbial communities and natural ecosystems
Waste Disposal: Incinerate in a chemical incinerator equipped with afterburner and scrubber, avoid landfill or drain disposal
Contaminated Packaging: Triple rinse and dispose as hazardous waste according to local regulations
Environmental Release: Never flush into sewage, watercourses, or open ground; uncontrolled release causes long-term disruptions
UN Number: Not classified as dangerous under current regulations
Transport Hazard Class: Non-hazardous for air, land, and sea based on standard chemical lab quantities
Packing Group: Not regulated, but containers should prevent breakage and keep out moisture
Special Transport Precautions: Protect from physical damage, use secondary containment during transit if bulk shipping locally
EU Classification: Listed under REACH, not subject to compulsory registration in common laboratory uses
OSHA Status: Not listed as a hazardous chemical, but occupational sensitizer concerns noted
Other Regulations: Complies with US TSCA, identified under pharmaceutical waste rules
Workplace Controls: Subject to local biosafety rules for antimicrobial agents and antibiotics
Labelling: Clearly labeled with hazard pictograms and warnings based on possible allergic response, environmental risk
