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Product Name: Amiloride Hydrochloride
Chemical Formula: C6H8ClN7O·HCl
Synonyms: Amiloride HCl; 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide mono-hydrochloride
CAS Number: 2016-88-8
Recommended Use: Diuretic medication, research chemical
Manufacturer Information: Contact details from the supplier’s packaging
Emergency Contact: Refer to local emergency number or manufacturer emergency line
GHS Classification: Eye irritation, Skin irritation, Specific target organ toxicity
Label Elements: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Causes moderate eye and skin irritation; Harmful if inhaled or swallowed
Precautionary Statements: Avoid breathing dust or spray; Wash thoroughly after handling; Use only outdoors or in a well-ventilated area; Wear protective gloves, protective clothing, and eye protection
Pictograms: Standard GHS pictograms for irritants and health hazards
Possible Routes of Exposure: Inhalation, ingestion, eye and skin contact
Chemical Name: Amiloride Hydrochloride
Percentage: >98%
Impurities: May contain trace amounts of synthetic intermediates and by-products
Common Additives: None typically present in raw material
Molecular Weight: 266.1 g/mol (anhydrous), 302.1 g/mol (monohydrate)
Inhalation: Move person to fresh air immediately; seek medical attention if symptoms like coughing or breathing difficulty persist
Skin Contact: Remove contaminated clothing right away; rinse skin with plenty of water for at least 15 minutes; call a doctor if irritation continues
Eye Contact: Rinse cautiously with water for several minutes; remove contacts if present and safe; continue rinsing; seek medical care if redness or pain persists
Ingestion: Do not induce vomiting; rinse mouth thoroughly; get medical attention if the chemical is swallowed
Important Symptoms: Eyes and skin may turn red or feel uncomfortable; ingestion can lead to nausea, stomach upset, or headache
Advice for Medical Providers: Treat symptomatically; monitor vital signs, especially with large exposures
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Do not use jet of water directly on burning material
Specific Hazards: Burning may produce toxic fumes such as nitrogen oxides and hydrogen chloride
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing
Special Firefighting Procedures: Keep containers cool using water spray; avoid inhaling fumes; remove containers from fire area if safe
Combustion Products: Hazardous gases like carbon monoxide, carbon dioxide, and hydrogen chloride could be released in a fire
Personal Precautions: Wear gloves, eye protection, and dust mask or respirator if powder is airborne; restrict access to spill area
Environmental Precautions: Prevent chemical from entering drains, surface water, or soil
Spill Cleanup Methods: Scoop or sweep up spilt powder, avoiding creating dust; place in tightly sealed container for disposal; wash contaminated surface with water and detergent
Decontamination: Clean area after collection of material; ventilate enclosed spaces
Waste Disposal: Dispose of collected material using licensed waste handler
Handling Precautions: Use in well-ventilated area; avoid dust formation; avoid contact with skin, eyes, and clothing; do not eat, drink, or smoke while using
Storage Conditions: Store tightly closed in original container; keep in cool, dry place away from light and incompatible substances
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Engineering Controls: Use of fume hood or local exhaust recommended
Special Requirements: Reserve for trained personnel; keep out of reach of children and pets
Exposure Limits: No OSHA or ACGIH limits assigned for Amiloride Hydrochloride
Engineering Controls: Use local exhaust ventilation or chemical fume hood
Personal Protective Equipment (PPE): Lab coat or apron, chemical-resistant gloves (nitrile or neoprene), safety glasses or goggles
Respiratory Protection: NIOSH-approved mask in situations with dust or aerosol
Hygiene Measures: Wash hands after handling; keep work clothing separate; shower after work if large amounts handled
Environmental Controls: Try to reduce airborne dust and emissions
Appearance: Pale yellow to light yellow crystalline powder
Odor: Odorless or faint chemical odor
Odor Threshold: Not available
pH: 3.5 to 4.5 in solution
Melting Point: 274–279°C (decomposition may occur on melting)
Boiling Point: Decomposition before boiling
Solubility: Soluble in water, very slightly soluble in ethanol
Partition Coefficient (log Kow): Not available
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.6 g/cm³
Viscosity: Not applicable
Evaporation Rate: Not applicable
Flammability: Not considered flammable under normal conditions
Explosive Limits: Not available
Decomposition Temperature: Above 250°C
Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: Reacts with strong oxidizers; no hazardous polymerization expected
Conditions to Avoid: Exposure to light, prolonged heat, ignition sources
Incompatible Materials: Oxidizing agents, strong acids, strong bases
Decomposition Products: Releases hydrogen chloride, nitrogen oxides, and carbon oxides on heating or burning
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Limited data available; ingestion of large amounts may be harmful
Skin Irritation: May cause redness or discomfort
Eye Irritation: May cause pain and redness
Chronic Effects: No chronic toxicity established for humans at typical exposures; chronic use in medical treatment may impact electrolyte balance
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No data available
Mutagenicity: No data available
Medical Conditions Aggravated by Exposure: May worsen symptoms in persons with existing kidney or electrolyte disorders
Environmental Impact: Information is limited for the compound in aquatic and soil systems
Aquatic Toxicity: Harmful to aquatic organisms if released in large amounts
Persistence and Degradability: May not easily break down in water or soil, persistence possible
Bioaccumulative Potential: Data not available
Mobility in Soil: Compound is soluble in water, may be mobile
Other Ecological Data: Avoid release to the environment; no indication of widespread natural occurrence
Disposal Methods: Dispose in compliance with local, regional, and national environmental regulations
Container Disposal: Empty containers must be rinsed and disposed of as chemical waste
Special Precautions: Prevent release into sewers or natural waterways; labeling as hazardous waste typically required
Disposal of Unused Product: Send to licensed chemical waste disposal company
RCRA Status: Not a listed RCRA hazardous waste, but always verify with current regulations
UN Number: Not regulated for transport by land, air, or sea in most jurisdictions
Transport Hazard Class: Not classified as dangerous good
Packing Group: Not applicable
Proper Shipping Name: Amiloride Hydrochloride
Environmental Hazards: None indicated
Special Transport Precautions: Maintain tightly sealed packaging; prevent spillage or dust; transport according to general chemical transportation guidelines
Regulatory Agencies: Refer to US DOT, IATA, and IMO for up-to-date information
Inventory Status: Listed on US TSCA, EU EINECS/ELINCS, and other chemical inventories as applicable
Federal Regulations: Subject to standard workplace safety and reporting requirements for pharmaceuticals and chemicals
Labeling Requirements: Follows GHS and OSHA requirements for hazard communication
Additional Safety Measures: Users must comply with all applicable local, state, and national regulations related to handling pharmaceuticals
Worker Protections: OSHA standards require provision of MSDS, hazard training, and access to PPE
Product Restrictions: Pharmaceutical uses require prescription or license; not sold to the public as raw compound
EU Classification: Classified according to current European regulation, REACH registration required for quantities above threshold
