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Product Name: Amcinonide
Chemical Formula: C28H34F2O5
CAS Number: 51022-69-6
Synonyms: 9α-Fluoro-16α,17α-isopropylidenedioxypregna-1,4-diene-11β,21-diol-3,20-dione
Intended Use: Topical corticosteroid for dermatological conditions
Manufacturer: Check product label for supplier information
Emergency Phone: See local emergency numbers on packaging
Recommended Restrictions: For prescription and healthcare professional use only
Classification: Not classified as hazardous based on GHS criteria for finished product, but bulk form requires care
Signal Word: Caution
Hazard Statements: Exposure may cause serious eye irritation, possible skin reactions, respiratory sensitization if inhaled repeatedly
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Avoid breathing dust. Wear protective gear.
Potential Health Effects: Overexposure can cause local skin thinning, immune suppression, and endocrine effects with chronic use
Target Organs: Skin, eyes, adrenal glands
Label Elements: May include exclamation mark pictogram for irritant effects
Chemical Name: Amcinonide
Concentration: Typically 0.05% (in topical formulation); higher in raw material
Other Ingredients: Not applicable in pure material; refer to formulation for excipients
Impurities: Manufacturer specifies quality controls for active pharmaceutical ingredient
OSHA Status: Not listed as a hazardous chemical under OSHA regulations
Eye Contact: Rinse gently with water for 15 minutes. Remove contact lenses if present and safe to do so. Seek medical attention if irritation occurs.
Skin Contact: Wash exposed skin with soap and water. Remove contaminated clothing. Seek medical attention for persistent irritation or redness.
Inhalation: Move to fresh air. If breathing becomes difficult or adverse effects occur, seek medical help.
Ingestion: Rinse mouth with water. Do not induce vomiting. Get medical advice if large quantities swallowed.
Important Symptoms: Redness, rash, burning, possible delayed hypersensitivity reactions
Special Advice to Doctors: Treat symptomatically. Monitor for adrenal suppression or systemic corticosteroid symptoms after significant exposure.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam. Choose extinguishing agents based on surrounding fire.
Unsuitable Extinguishing Media: High-pressure water jets may spread powder and should be avoided.
Specific Hazards: May produce toxic fumes under fire conditions, such as carbon oxides and hydrogen fluoride
Protective Equipment: Firefighters require self-contained breathing apparatus, protective clothing, chemical-resistant gloves
Advice for Firefighters: Keep containers cool with water spray. Prevent run-off from entering drains or watercourses.
Combustion Products: May include carbon monoxide, carbon dioxide, fluorinated compounds
Personal Precautions: Evacuate non-essential personnel. Use respiratory protection and gloves to avoid dust generation.
Containment: Prevent material from entering drains or water sources. Clean-up should be completed by trained personnel.
Cleanup Methods: Scoop up bulk material with non-sparking tools. Dampen with water to avoid dispersion. Wipe area with wet cloth.
Environmental Precautions: Avoid runoff to waterways. Notify authorities in case of significant discharge.
Disposal: Collect spilled material and dispose in accordance with local regulations.
Handling Precautions: Avoid dust formation. Do not breathe dust. Prevent handling near open flame or sources of ignition.
Storage: Store in tightly closed container. Keep cool and dry, protected from light. Do not store with incompatible substances such as strong oxidizers.
Storage Location: Secure area accessible only to trained personnel. Ensure ventilation meets safety guidelines.
Hygienic Practices: Wash thoroughly after handling. Maintain housekeeping to prevent accumulation.
Exposure Limits: No specific occupational exposure limits set for Amcinonide
Engineering Controls: Work in well-ventilated areas or use fume hoods if dust is generated
Personal Protection: Wear gloves, chemical safety goggles, lab coat or coveralls. Use NIOSH-approved respiratory masks in powder-handling scenarios.
Environmental Controls: Use containment technology and dust extraction systems to prevent release.
Other Safety Measures: Do not eat, drink, or smoke in areas where this chemical is handled. Change contaminated clothing promptly.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined (insoluble in water)
Melting Point: About 277°C
Boiling Point: Not available
Flash Point: Not established
Evaporation Rate: Not available
Flammability: Not classified as flammable, though combustion may occur in fire
Solubility: Practically insoluble in water. Soluble in organic solvents like methanol, ethanol, chloroform.
Vapor Pressure: Not available
Density: Not available
Partition Coefficient (Log Pow): Not established
Decomposition Temperature: Not specified
Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions expected under normal use
Conditions to Avoid: Strong sources of heat, light, moisture, incompatible chemicals
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Carbon oxides, hydrogen fluoride, possible toxic fumes under fire
Polymerization: No known hazardous polymerization
Routes of Exposure: Eye, skin, inhalation, ingestion
Acute Toxicity: May cause irritation to eyes, skin, respiratory tract
Chronic Effects: Prolonged use increases risk of skin atrophy, systemic corticosteroid effects, immunosuppression, adrenal suppression
Skin Sensitization: Rare allergic reactions, possible in sensitive individuals
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Mutagenicity: No data indicating mutagenic potential
Reproductive Effects: May impact fetal development in high doses; medical guidance advised for pregnant or breastfeeding patients
Other Health Information: Corticosteroids absorbed through skin can affect hormone levels with prolonged/high dose application
Ecotoxicity: No specific ecotoxicological data available for Amcinonide
Persistence and Degradability: Not rapidly biodegradable; persistence in environment likely
Bioaccumulation: No quantitative data; potential for accumulation in aquatic organisms based on chemical properties
Mobility in Soil: Expected to have limited mobility due to low water solubility
Other Adverse Effects: Avoid release into waterways, as corticosteroids can disturb aquatic ecosystems
Waste Disposal Methods: Dispose of material, contaminated packaging, and clean-up residues in accordance with local, regional, and national regulations.
Incineration: Preferred method in accordance with environmental requirements for pharmaceuticals
Precautions: Do not flush unused material down the drain
Container Disposal: Triple rinse and puncture empty containers before discarding in a permitted facility
Special Instructions: Refer to local hazardous waste agency for final disposal options
UN Number: Not classified as dangerous goods under transport regulations
Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Marine Pollutant: Not listed
Special Precautions: Keep in original containers. Avoid heat and direct sunlight during transit.
US Regulations: Subject to FDA oversight as pharmaceutical product; not listed under SARA Title III, CERCLA, or TSCA
EU Regulations: Not classified as a hazardous substance under REACH.
Labelling Requirements: Must carry prescription and hazard statements set by regulatory authorities
Workplace Safety: Observe occupational health guidelines for corticosteroid handling
Other Requirements: Observe all state and local regulations for handling and dispensing of prescription drugs
