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Product Name: Almitrine Dimesylate
Chemical Formula: C_26H_35F_2N_5O_4·2CH_4O_3S
Synonyms: Almitrine Mesylate, Almitrine 2-methanesulfonate salt
CAS Number: 72608-72-9
Manufacturer: Pharmaceutical-grade chemical suppliers
Recommended Use: Pharmaceutical research, active pharmaceutical ingredient development
Contact Number for Emergency: Refer to local poison control or chemical safety hotline
Hazard Classifications: Acute oral toxicity (Category 4), Serious eye irritation (Category 2), Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes serious eye irritation; may cause skin irritation
Pictograms: Exclamation Mark
Precautionary Information: Do not breathe dust or vapors; avoid contact with eyes, skin, and clothing; wash thoroughly after handling
Target Organs: Central nervous system, respiratory system
Chemical Name: Almitrine Dimesylate
Concentration: ≥98% by weight
CAS Number: 72608-72-9
Impurities: Related synthesis byproducts <2% (specific identities vary by batch), residual solvents <0.1%
Molecular Weight: 789.95 g/mol (as dimesylate salt)
Inhalation: Remove exposed individual to fresh air, support breathing as needed, consult medical professional immediately
Skin Contact: Rinse with running water for at least 15 minutes, remove contaminated clothing, seek medical attention for irritation
Eye Contact: Flush with water for at least 10 minutes keeping eyelids open, do not rub eyes, seek immediate medical care
Ingestion: Rinse mouth, do not induce vomiting unless directed by health care professional, obtain prompt medical advice
General Notes: Provide physician with details of substance and circumstances, keep affected person under supervision
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Unsuitable Media: Direct water jet (may spread contamination)
Special Hazards: Toxic gases (sulfur oxides, nitrogen oxides, carbon oxides, hydrogen fluoride) may develop under fire conditions
Protective Equipment: Wear full protective gear including self-contained breathing apparatus and chemical-resistant clothing
Firefighting Procedures: Approach from upwind, evacuate area if possible, prevent runoff into drains and natural water sources
Personal Protection: Use personal protective equipment including gloves, safety goggles, lab coat, and respirator if dust present
Environmental Precautions: Prevent spillage from entering soil, waterways, or drains, report to authorities per local laws
Containment: Sweep up carefully to avoid dust formation, place in sealed chemical waste container
Cleanup Methods: Use absorbent material such as inert sand, avoid dry sweeping that stirs dust, ventilate area thoroughly
Handling Requirements: Work in a well-ventilated area, minimize dust generation, avoid physical contact, wash hands and skin after use
Technical Measures: Use explosion-proof electrical equipment, static-free shoes and containers if possible
Storage Conditions: Store in tightly sealed container away from light, moisture, and incompatible substances (oxidizers, acids)
Temperature: Store between 2–8°C in dedicated hazardous materials storage
Incompatibilities: Strong oxidizers, acids, basis, halogens
Exposure Limit Values: Occupational exposure limits not established for Almitrine Dimesylate
Engineering Controls: Laboratory fume hood or local exhaust, airtight chemical storage, emergency eye wash and showers
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), laboratory safety goggles, respiratory protection if airborne concentrations detected, lab coat or overall, closed footwear
Hygiene Measures: Avoid eating, drinking, smoking in work area, wash hands before breaks and at end of shift, routine environmental monitoring for airborne particulates
Appearance: White to off-white crystalline powder
Molecular Weight: 789.95 g/mol (dimesylate form)
Odor: Odorless or faint, medicinal
Melting Point: 176–180°C (reported for dimesylate)
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in water, DMSO, slightly soluble in ethanol
pH: 4.0–5.5 (1% aqueous solution)
Vapor Pressure: Not applicable (solid at room temperature)
Partition Coefficient (log P): Not established
Flash Point: Not relevant
Explosive Properties: No data, not known to be explosive
Other Data: Stable under recommended storage and handling conditions
Chemical Stability: Stable under standard storage, sensitive to moisture and light
Reactivity: Little reaction under routine conditions, avoid exposure to strong oxidizers
Hazardous Reactions: May produce toxic decomposition gases under high heat or with strong acids
Decomposition Products: Carbon oxides, sulfur oxides, fluorine compounds, nitrogen oxides
Polymerization: Does not undergo dangerous polymerization
Acute Toxicity: Toxicity may occur after oral, inhalation, or dermal absorption (data from animal studies suggests LD50 (oral, rat) ~ 40-300 mg/kg for active component, mixture may differ)
Chronic Effects: Repeated or prolonged exposure could lead to central nervous system impairment, respiratory irritation, gastrointestinal disturbance
Sensitization: May potentially cause allergic or sensitization reactions in susceptible individuals
Symptoms of Exposure: Headache, dizziness, nausea, irritation of mucous membranes, skin or eyes
Carcinogenicity: Not listed as carcinogenic (IARC, NTP, OSHA)
Mutagenicity: No data available on genetic mutation
Reproductive toxicity: No data available, pharmaceuticals of this class may present risk, handle as though reproductive toxicity may occur
Aquatic Toxicity: No specific data for Almitrine Dimesylate; structurally related substances demonstrate moderate toxicity in aquatic organisms
Persistence and Degradability: Exact environmental breakdown is not fully known, may persist in water and soil
Bioaccumulation Potential: No detailed studies on accumulation in biota; pharmaceutical residues may impact aquatic microflora and fauna
Mobility in Soil: Likely mobile in water, particularly under acidic conditions
Other Environmental Hazards: Take measures to prevent release into the ecosystem, unknown long-term effects on environment
Waste Treatment Method: Dispose of as hazardous pharmaceutical waste in accordance with local regulatory requirements
Disposal Containers: Use sealed, labeled chemical waste containers resistant to leaks
Contaminated Packaging: Handle and dispose of packaging as hazardous chemical waste
Precautions: Do not flush into drains or allow to contaminate water sources, use authorized chemical disposal contractors
UN Number: Not assigned a specific UN number, transport as hazardous laboratory chemical
Transport Class: Treat with general caution for pharmaceutical actives
Proper Shipping Name: Laboratory chemical, not otherwise specified
Packing Group: Based on quantities and containment; follow local regulations
Transport Hazard Class: Not classified under ADR/RID/IMDG/IATA unless transported in significant quantities; check with carrier
Special Precautions: Minimize motion and impact, use secure, sealed packaging, maintain temperature below 25°C during transit
Global Chemical Inventories: Not listed on TSCA, EINECS, DSL, or AICS for use as raw material; restricted to research or pharmaceutical manufacturing
OSHA HazCom Status: Considered hazardous under OSHA Hazard Communication Standard
REACH Status: Not registered for non-pharmaceutical applications in the EU
Labeling: Hazard pictogram, hazard statements, precautionary statements as required for laboratory chemicals
Other Regulations: Usage, handling, and disposal may require notification to local agencies; export subject to controlled substance regulations depending on jurisdiction
Worker Protection: Compliance with employee right-to-know, safety training, and personal protective equipment requirements
