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Product Name: Allopregnanolone
SYNONYMS: 3α-hydroxy-5α-pregnan-20-one, 5α-pregnan-3α-ol-20-one
CAS Number: 566-65-8
Recommended Use: Laboratory chemical, research use only
Manufacturer: [Company contact details according to latest supply source]
Emergency Phone: [24-hour response, available through national poison control]
Product Description: White to off-white crystalline powder, odorless.
GHS Classification: Not classified as hazardous according to GHS criteria
Signal Word: Not applicable
Hazard Statements: No significant acute hazard under normal laboratory conditions
Precautionary Statements: Wear suitable protective clothing, gloves, and eye/face protection during handling
Health Hazards: May cause mild skin or eye irritation through direct exposure; ingestion or inhalation in large quantities not well-studied.
Environmental Hazards: No data available regarding significant hazards to aquatic life or other organisms.
Chemical Name: Allopregnanolone
Chemical Formula: C21H34O2
Molecular Weight: 318.5 g/mol
PURITY: >98% (as provided by supplier)
IMPUURITIES: Typically less than 2%, consisting of structurally related steroids.
Inhalation: Remove person to fresh air immediately, obtain medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse gently with plenty of water for at least 10 minutes while holding eyelids open, seek medical advice
Ingestion: Rinse mouth, seek medical attention if symptoms occur; do not induce vomiting unless directed by medical personnel
General Advice: Show the product label or this MSDS to medical staff.
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam
Unsuitable Extinguishing Media: High-pressure water jets may spread fire
Specific Hazards Arising from Chemical: Thermal decomposition can generate carbon oxides, potential irritating fumes
Protective Equipment & Precautions: Firefighters should wear self-contained breathing apparatus and full protective gear
Fire/Explosion Risk: Does not pose significant fire or explosion hazard under usual storage or handling.
Personal Precautions: Use appropriate personal protective equipment, avoid dust formation
Environmental Precautions: Prevent further leakage if safe, do not allow material to enter drains, surface or ground water
Cleanup Methods: Sweep or vacuum up material and collect in a properly labeled waste container for disposal, ventilate area and wash spill site after material pickup is complete.
Handling: Avoid generating dust, avoid inhalation or contact with skin, eyes, and clothing; practice good industrial hygiene and safety procedures
Storage Conditions: Keep container tightly closed in a well-ventilated, dry, cool place; protect from light and incompatible materials such as strong oxidizers
Incompatible Materials: Strong oxidizing agents, acids and bases may react with product
Specific End Use: For laboratory and research use only, not for diagnostic or therapeutic applications.
Engineering Controls: Work under a chemical fume hood where possible, provide adequate ventilation
Eye/Face Protection: Chemical safety goggles
Skin Protection: Suitable gloves (e.g., nitrile or latex), laboratory coat
Respiratory Protection: Use dust masks or respirators if dust is generated
Work Hygiene: Wash hands thoroughly before breaks and after handling, avoid eating or drinking in work area
Exposure Limits: No occupational exposure limits set by OSHA, NIOSH, or ACGIH.
Appearance: White to off-white crystalline solid
Odor: Odorless
Melting Point: 163–165°C
Boiling Point: Not available
Solubility: Insoluble in water; soluble in ethanol, DMSO, acetone
Vapor Pressure: No meaningful vapor pressure at room temperature
Flash Point: Not available
Density: Approximately 1.07 g/cm³
pH: Not applicable
Partition Coefficient (log Kow): Estimated 4.1 (highly lipophilic)
Stability: Chemically stable under recommended storage conditions.
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: Will not polymerize
Conditions to Avoid: Moisture, light, excessive heat
Incompatible Materials: Strong oxidizing agents, acids,\
alkalis
Decomposition Products: May produce carbon monoxide, carbon dioxide and other potentially toxic fumes in case of fire or decomposition.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: No acute toxicity data available for humans; animal studies show low acute toxicity
Chronic Toxicity: Not established for occupational exposure
Potential Effects: May cause mild irritation to skin or eyes, inhalation of dust may cause respiratory discomfort
Carcinogenicity: Not listed as a carcinogen by NTP, IARC, OSHA
Mutagenicity: No evidence of mutagenic potential from animal or cellular studies
Reproductive Toxicity: No known reproductive health risks reported
Target Organs: No known chronic target organ effects.
Ecotoxicity: No data available regarding effects on aquatic or terrestrial organisms
Persistence and Degradability: Unknown; as a steroid, potential for persistence in environment
Bioaccumulation Potential: Estimated moderate to high due to lipophilicity, but no experimental data
Mobility in Soil: Expected low mobility due to low water solubility
Other Adverse Effects: No known significant environmental hazards at laboratory-scale use.
Waste Treatment Methods: Dispose of product in accordance with local, regional, and national regulations for laboratory chemicals
Contaminated Packaging: Triple-rinse and offer for recycling if possible or dispose as laboratory waste
Special Precautions: Avoid release into the environment or sewers, minimize disposal quantities, label waste clearly for chemical content.
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not relevant
Environmental Hazards: None identified at laboratory quantities
Special Precautions: Use secondary containment, comply with local shipping and packaging regulations for laboratory chemicals.
TSCA Status: Listed or exempted
SARA Title III Sections 302/313: Not listed
CERCLA: Not a hazardous substance
California Prop 65: Not listed
WHMIS: Not controlled under WHMIS regulations
Other National Inventories: Present or exempt under most chemical regulatory inventories; consult regional lists for compliance.
