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Chemical Name: Allantoin
Common Uses: Skin care formulations, pharmaceuticals, personal hygiene products
Chemical Formula: C4H6N4O3
Physical Appearance: White, odorless powder
Synonyms: Glyoxyldiureide, 5-Ureidohydantoin
Solubility: Soluble in hot water; slightly soluble in cold water and alcohol
Odor: Practically odorless
Health Hazards: Low toxicity; unlikely to cause harm in normal use
Skin Contact: May cause mild irritation in concentrated form
Inhalation: Dust may cause mild respiratory discomfort
Eye Contact: Can lead to minor irritation if powder enters the eye
Ingestion: Not considered toxic, yet swallowing large amounts is not advised
Appearance of Risk: Not considered hazardous under standard use
Allantoin Content: Over 99% pure
Impurities: Trace levels of manufacturing by-products, typically below reporting thresholds
Inhalation: Move to fresh air, seek medical attention if symptoms persist
Skin Contact: Wash gently with water if irritation occurs
Eye Contact: Rinse under running water for several minutes; seek medical help if discomfort continues
Ingestion: Rinse mouth out; medical attention is unlikely needed unless consuming excessive amounts
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Potential Hazards: Dust may form explosive mixtures with air, though not likely in regular use
Protective Equipment: Standard firefighting gear; avoid breathing smoke
Decomposition Products: Oxides of carbon and nitrogen may develop only at high temperatures
Personal Precautions: Minimize dust, ventilate area, avoid direct skin and eye contact
Cleanup Methods: Sweep up, place in a suitable closed container; avoid raising dust clouds
Environmental Precautions: Prevent entry of large spills into surface waterways
Handling: Transfer using techniques that reduce dust generation; maintain good industrial hygiene practices
Storage Conditions: Store in a cool, dry, well-ventilated area in tightly sealed containers
Incompatible Materials: Strong oxidizers may react with Allantoin; most common storage methods suffice
Special Considerations: Label containers clearly to avoid confusion in shared facilities
Occupational Exposure Limits: Not assigned a specific exposure limit, yet minimizing dust exposure remains sensible
Engineering Controls: General room ventilation often works, with extra attention during powder transfer
Personal Protection: Gloves and safety glasses recommended when working with the undiluted powder; use dust mask if airborne powder may be present
Molecular Weight: 158.12 g/mol
Form: Crystalline or powdered solid
Color: White
Melting Point: Around 230°C with decomposition
Boiling Point: Not applicable; decomposes before boiling
Solubility in Water: Approximately 0.5% at room temperature
pH (10% in water): Nearly neutral (around 6-7.5)
Viscosity, Flash Point, Vapor Pressure: Not applicable for a solid like Allantoin
Chemical Stability: Stable under typical use and storage conditions
Reactivity: Not reactive with water or most commonly encountered materials
Hazardous Reactions: Does not undergo hazardous polymerization
Decomposition: Can break down at high temperature, releasing carbon oxides and nitrogen oxides
Incompatible Materials: Strong oxidizing agents
Acute Toxicity: Practically non-toxic; extensive use in personal care and medical products supports low health risk
Skin Irritation: Unlikely except in concentrated powder or with prolonged contact
Eye Irritation: Possible mild discomfort if dust enters eyes
Sensitization: Rare reports of allergic skin reaction; not common
Long-Term Effects: No evidence of carcinogenic, mutagenic, or reproductive hazards from normal exposure
Inhalation Effects: Only relevant if large amounts of dust present
Environmental Fate: Biodegradable; breaks down in soil and water without persistent residues
Toxicity to Aquatic Life: Low toxicity; not expected to build up in organisms
Mobility in Soil: Readily disperses and degrades
Persistence and Degradability: Readily degraded by microorganisms
Bioaccumulation: Not anticipated
Recommended Disposal: Small quantities may go to regular waste under most local regulations
Large Scale or Industry Use: Dispose of in accordance with local, regional, and national regulations to avoid unnecessary environmental impact
Waste Considerations: Minimize dust during transfer to keep airborne exposure down for handlers
UN Number: Not regulated
Hazard Class: Not classified as dangerous goods for land, sea, or air transport
Shipping Considerations: Use standard packaging to prevent contamination and moisture ingress
Labeling: Not subject to special transport labeling rules
GHS Classification: Not routinely classified as hazardous
REACH/TSCA/EU: Compliant for use in cosmetics and pharmaceuticals; always check updates for new requirements
Other Regulations: Use in cosmetics, pharmaceuticals, and personal care well established and recognized by EU and U.S. agencies
Workplace Requirements: General industrial safety and hygiene good practice continue to be the best policy
