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Product Name: Albuterol Sulfate
Synonyms: Salbutamol Sulfate, Albuterol hemisulfate
Chemical Formula: C13H21NO3 • H2SO4
Molecular Weight: 576.7 g/mol
Recommended Use: For pharmaceutical formulation and research purposes
Manufacturer: Listed by specific supplier or facility responsible
Contact Information: Includes emergency contact phone, address of organization
CAS Number: 51022-70-9
GHS Classification: Eye irritation (Category 2A); Specific target organ toxicity, single exposure (Category 3)
Label Elements: Exclamation mark pictogram, Signal word: Warning
Hazard Statements: Causes irritation to eyes, skin, and respiratory tract; may cause allergy or asthma symptoms or breathing difficulties if inhaled; may affect cardiovascular and nervous systems in high doses
Precautionary Statements: Avoid breathing dust or powder, wash hands thoroughly after handling, use only in well-ventilated area
Emergency Overview: White to off-white crystalline powder, avoid creating dust, seek medical help if symptoms develop
Chemical Identity: Albuterol Sulfate
Purity: Greater than 98%
Impurities: Related compounds under specified limits set by pharmacopeia
Common Additives: None expected if pure substance
Active Ingredient: Albuterol Sulfate (100%)
Inhalation: Move person outdoors, keep at rest in a position comfortable for breathing, seek medical advice if any difficulty occurs
Ingestion: Rinse mouth with water, do not induce vomiting, consult doctor immediately if symptoms present
Skin Contact: Remove contaminated clothing, wash area with soap and water, medical attention required for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing
Most Important Symptoms: Difficulty breathing, coughing, skin or eye irritation, allergic reactions
Medical Attention: Symptomatic treatment as required
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: None known for small laboratory quantities
Fire Hazards: Powder may form explosive dust-air mixtures; hazardous decomposition includes oxides of carbon and nitrogen, sulfur oxides
Firefighting Equipment: Wear self-contained breathing apparatus, full protective clothing
Special Precautions: Control runoff from firefighting to prevent environmental contamination
Personal Precautions: Wear respirator, chemical-resistant gloves, protective goggles, suitable lab coat
Environmental Precautions: Keep out of waterways, sewers, drains; avoid soil discharge
Methods for Cleanup: Scoop up or sweep spilled powder with minimal dust generation, collect in labeled container for disposal
Decontamination: Clean area with damp cloth, dispose of cleaning material as hazardous waste, ventilate area well
Handling: Use in chemical fume hood or well-ventilated area, avoid dust formation, do not eat or drink in work area, wash hands after use
Storage: Store in tightly sealed container, keep away from incompatible substances, protect from light, moisture, and heat; recommended temperature below 25°C
Incompatibilities: Strong oxidizers, acids, bases
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH limits; exposure kept as low as reasonably achievable due to sensitization risks
Engineering Controls: Well-ventilated space, preferably with local exhaust
Eye Protection: Safety goggles
Skin Protection: Nitrile or other chemical-resistant gloves; lab coat or gown
Respiratory Protection: Approved dust respirator, especially for powder handling
Hygiene Measures: Avoid contact with skin, eyes, and clothing, remove contaminated clothing promptly, wash hands thoroughly
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: 3.5 – 5.5 (1% solution in water)
Melting Point: 192°C to 195°C (decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not available
Evaporation Rate: Not available
Flammability: Not classified as flammable, can form dust explosion hazard
Explosion Limits: Not determined
Vapor Pressure: Negligible
Solubility: Freely soluble in water, sparingly soluble in ethanol, insoluble in chloroform and ether
Partition Coefficient (Log Kow): -0.31 (for base)
Vapor Density: Not applicable
Relative Density: 1.2 g/cm³ (approximate)
Decomposition Temperature: Above 190°C
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Non-reactive under normal use conditions
Incompatible Materials: Strong oxidizing agents, reducing agents
Hazardous Decomposition: May release carbon oxides, nitrogen oxides, sulfur oxides on extreme heating
Hazardous Polymerization: Not expected
Acute Toxicity: LD50 (oral, mouse) 2,100 mg/kg; may cause harm if swallowed, inhaled, or absorbed through skin
Skin Corrosion/Irritation: Can cause irritation with redness and possible rash
Eye Damage/Irritation: May cause inflammation, watering, redness
Respiratory Sensitization: May trigger asthma-like symptoms in sensitized individuals
Germ Cell Mutagenicity: Evidence not conclusive
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Reproductive Toxicity: Some animal studies indicate possible developmental effects at high doses
STOT (Single Exposure): Drowsiness, palpitations, tremor reported in overdose
Chronic Effects: Prolonged high exposure can disrupt cardiac rhythm
Ecotoxicity: Harmful to aquatic life with long-lasting effects; published data signals risk to daphnia and some fish species
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulative Potential: Bioaccumulation low, based on low partition coefficient values
Mobility in Soil: High solubility increases mobility; potential leaching to groundwater
Other Adverse Effects: Avoid release to environment, toxic to aquatic microflora and fauna
Waste Disposal Methods: Dispose in accordance with local, regional, and national regulations for hazardous waste
Contaminated Packaging: Clean containers before recycling or dispose of as hazardous waste if heavily contaminated
Incineration: Authorized incineration facilities recommended
Precautions: Avoid discharge into drains or watercourses
UN Number: Not regulated as dangerous good for transport (IATA, IMDG, DOT)
Proper Shipping Name: Not applicable
Transport Hazard Class: Not applicable/
Packing Group: Not applicable/
Environmental Hazards: Not considered marine pollutant
Special Transport Precautions: Secure packaging to prevent damage or powder escape in transit
Safety, Health and Environmental Regulations: Listed in country-specific and international inventories as a pharmaceutical/regulated substance
SARA Title III (Section 313): Not listed
California Proposition 65: Not listed
WHMIS Classification (Canada): D2B (Toxic material causing other toxic effects)
REACH Status (EU): Exempt as a medicinal product, may trigger registration under laboratory use
Other Regulations: Handle as per pharmaceutical safety standards, include product-specific safety guidelines under workplace rules
