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Product Name: Albendazole
Chemical Name: Methyl 5-(propylthio)-2-benzimidazolecarbamate
Synonyms: Zentel, Eskazole, Albenza
CAS Number: 54965-21-8
Molecular Formula: C12H15N3O2S
Molecular Weight: 265.33 g/mol
Manufacturer: [Details supplied by supplier]
Recommended Use: Anthelmintic, used for treatment of parasitic worm infestations
Classification: Harmful if swallowed, eye irritant, reproductive toxicity concern
Route of Exposure: Inhalation, ingestion, skin, and eye contact
Signal Word: Warning
Hazard Statements: May cause harm to the unborn child. Causes eye irritation. Prolonged skin contact may cause mild irritation. Harmful if swallowed.
Pictograms: Health hazard, exclamation mark
Prevention: Avoid breathing dust. Wash hands thoroughly after handling. Wear protective gear to reduce exposure. Do not eat, drink, or smoke when using.
Albendazole: 98-100%
Impurities: 0-2%, proprietary or process dependent
Additives: Usually none in pure formulations. Refer to supplier for tablet or suspension excipients.
Inhalation: Move to fresh air. If breathing difficulty continues, seek medical attention.
Ingestion: Rinse mouth thoroughly. Give water if person is conscious. Do not induce vomiting without medical advice. Consult a doctor immediately.
Skin Contact: Wash thoroughly with soap and water. Remove contaminated clothing. If rash or irritation develops, get medical help.
Eye Contact: Flush eyes with plenty of water for multiple minutes, lifting both eyelids. Remove contact lenses if present and easy to do.
Medical Attention: Immediate intervention may be required in case of allergic response, serious ingestion, or prolonged symptoms.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray for larger fires.
Specific Hazards: May release toxic fumes of nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide.
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing. Avoid smoke and fumes.
Firefighting Procedures: Contain runoff to prevent environmental contamination. Remove containers from fire area if safe.
Personal Precautions: Use protective clothes, gloves, goggles, dust mask if needed. Prevent inhalation and contact with skin or eyes.
Spill Cleanup: Sweep up solid material carefully without raising dust. Place in a suitable, sealed, labeled container for disposal.
Environmental Precautions: Prevent material from entering drainage systems, surface waters, or soil.
Handling: Minimize dust. Use in well-ventilated area. Keep away from food and beverages. Practice good personal hygiene after handling.
Storage: Keep container tightly sealed. Store in cool, dry area, away from light, heat, and incompatible substances. Protect from moisture.
Incompatibilities: Strong oxidizing agents, acids, bases.
Occupational Exposure Limits: Not established for Albendazole. Use workplace controls and avoid repeat exposure.
Eye Protection: Safety goggles or face shield
Skin Protection: Chemical-resistant gloves, protective clothing
Respiratory Protection: Dust mask or particulate respirator if ventilation is insufficient
Other Protection: Facilities for eye washing and skin washing accessible near work area
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: Around 208–210°C
Boiling Point: Decomposes before boiling
Water Solubility: Practically insoluble (less than 0.1 mg/mL)
Partition Coefficient (log Pow): 3.1
Vapor Pressure: Not measurable at ambient conditions
Density: Approx. 1.3 g/cm³
Stability: Stable under normal handling and storage conditions
Reactivity: No hazardous reactivity under regular conditions.
Chemical Stability: Stable at room temperature in sealed container.
Hazardous Reactions: No known significant reactions, but avoid mixing with oxidizers.
Decomposition Products: Oxides of carbon, nitrogen, and sulfur when heated or burned.
Incompatible Materials: Strong acids, bases, oxidizing agents.
Polymerization: Will not occur in normal storage or use.
Acute Toxicity: LD50 (oral, rat) about 1320 mg/kg. Overdose causes nausea, vomiting, dizziness, headaches.
Skin: Low absorption, but may cause irritation in sensitive individuals.
Eyes: Can cause redness, pain, or irritation upon direct contact.
Ingestion: Harmful in large quantities. High doses linked to liver changes and bone marrow effects.
Chronic Effects: Prolonged or repeated exposure may affect the liver and reproductive organs.
Carcinogenicity: Not classified as human carcinogen by IARC or EPA; some animal studies show potential risk.
Mutagenicity/Teratogenicity: Some studies suggest risk of fetal harm; not recommended during pregnancy unless essential.
Aquatic Toxicity: Toxic to aquatic life in concentrated forms, particularly to fish and invertebrates.
Persistence and Degradability: Breaks down slowly in soil and water; not highly mobile.
Bioaccumulation Potential: Log Pow suggests moderate potential for bioaccumulation.
Mobility in Soil: Adheres to soil particles, remains in topsoil.
Other Harmful Effects: Research links exposure to impacts on soil microbes and earthworms at high concentrations.
Disposal Methods: Dispose in accordance with local and national laws. Incineration or controlled landfill in sealed containers preferred.
Packaging: Thoroughly wash and recycle packaging if allowed. Otherwise, treat as hazardous waste.
Waste Codes: Contact local waste authority for designation. Do not dispose in household waste or through wastewater.
Transport Status: Not regulated as hazardous under UN, IMO, IATA, or ADR regulations for ground, sea, or air.
Proper Shipping Name: Albendazole
Packing Group: Not applicable
Hazards to Avoid: Spillage or damage to packaging, prolonged exposure to sunlight or moisture
Labeling: Standard chemical handling information for non-hazardous pharmaceuticals
Worldwide Inventories: Listed on major regulatory chemical inventories, including TSCA, EINECS, AICS, DSL/NDSL.
Labelling Requirements: As per workplace chemical safety guidelines, includes hazard statements and precautionary symbols.
Restrictions: Prescription-only; only for licensed or controlled uses.
Other Regulations: Subject to veterinary and human medicine controls, GMP requirements for manufacturing, and environmental discharge laws.
REACH Status: Registered or exempted for European market.
OSHA Classification: Not classified as hazardous chemical in the workplace but follows general pharmaceutical handling rules.
WHMIS Status (Canada): Not controlled product but must be handled according to pharmaceutical best practices.
