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Product Name: Afoxolaner
Chemical Name: 4-[5-[(3,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropan-2-yl)phenyl)amino]-5-oxo-1,4-dihydro-1,2,4-triazol-1-yl]-N-isopropylbenzamide
CAS Number: 139007-81-7
Use: Veterinary medicine, used as an insecticide and acaricide, primarily in oral formulations for tick and flea control in dogs
Manufacturer: Check product packaging or consult with supplier for details
Emergency Contact: Refer to local poison control center or emergency response provider indicated on product label
Classification: Acute oral toxicity (Category 4), Eye irritation (Category 2B), Skin sensitization (Category 1)\
GHS Label Elements: Exclamation mark
Potential Health Effects: Exposure may cause mild skin or eye irritation, may lead to allergic skin reactions in sensitive individuals, accidental ingestion can cause nausea, vomiting, and other digestive symptoms, use around food-grade materials discouraged
Main Hazards: Mild irritant to eyes and skin, harmful if swallowed, not known to cause serious long-term health risks in normal veterinary use
Routes of Exposure: Skin contact, eye contact, ingestion
Environmental Hazards: Harmful to aquatic life with long lasting effects
Chemical Composition:
Inhalation: Remove person to fresh air, seek medical attention if symptoms persist
Skin Contact: Wash skin thoroughly with soap and water for several minutes, remove contaminated clothing, seek medical advice for persistent irritation
Eye Contact: Rinse eyes gently with water for at least 15 minutes, keep eyelids open, remove contact lenses if present, consult a doctor
Ingestion: Rinse mouth with water, seek medical attention, do not induce vomiting unless instructed by medical personnel
Acute Symptoms: May include mild nausea, slight burning sensation or rash on skin, mild eye discomfort
Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or foam; avoid water jets directly on product
Unsuitable Extinguishing Media: High-pressure water jets
Specific Hazards: Emits toxic fumes of hydrogen chloride, nitrogen oxides, and carbon oxides under fire conditions
Protective Equipment: Firefighters need self-contained breathing apparatus and suitable protective clothing
Precautions: Keep containers cool with water spray, move undamaged containers from fire area if safe
Combustion Products: Potential release of harmful gases such as hydrogen chloride and fluorinated compounds
Personal Precautions: Wear gloves, protective eyewear, and a mask, avoid skin and eye contact
Environmental Precautions: Prevent entry into waterways, sewers, or confined spaces, contain spill to avoid environmental contamination
Cleanup Methods: Absorb with inert material (e.g., sand or earth), collect and keep in suitable, closed, labelled containers for disposal
Decontamination: Wash contaminated area thoroughly with water and detergent after material pickup
Waste Disposal: Dispose residue and cleaning materials according to local regulations
Precautions: Handle in accordance with good hygiene and safety practices, avoid unnecessary exposure to dust or powder, do not eat, drink, or smoke during handling
Technical Measures: Use proper ventilation or local exhaust in work areas, keep containers tightly closed
Storage Conditions: Store in cool, dry, well-ventilated area and away from direct sunlight, moisture, and incompatible materials
Segregation: Keep away from oxidizing agents, strong acids, and bases
Container Materials: Store only in original, properly labelled containers, reseal tightly after use
Personal Protective Equipment:
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 212–214 °C
Boiling Point: Not available, decomposes before boiling
Solubility: Sparingly soluble in water, more soluble in common organic solvents
pH: Not applicable (insoluble in water)
Vapor Pressure: Not determined
Density: Approximately 1.5 g/cm³
Partition Coefficient (log Kow): 5.2 (estimated), reflects potential environmental persistence
Chemical Stability: Stable under recommended storage conditions, avoid prolonged exposure to direct sunlight or heat
Reactivity: Not known to react violently with water or common substances
Incompatibility: Keep away from strong acids, bases, and oxidizing materials
Hazardous Decomposition Products: Hydrogen chloride, carbon oxides, and nitrogen oxides produced under burning or decomposition
Polymerization: Not likely to occur under normal handling and use
Acute Toxicity: Oral LD50 in rats estimated at >1,000 mg/kg, low acute toxicity in recommended veterinary uses
Skin Irritation: Slightly irritating in some animal studies, unlikely to cause significant human skin reactions
Eye Irritation: May cause mild discomfort, does not lead to permanent damage
Sensitization: Patch testing shows a small percentage of individuals may develop skin allergy after repeated contact
Carcinogenicity: Not classified as carcinogenic based on current animal data
Chronic Effects: No evidence of reproductive or developmental toxicity in long-term studies
Symptoms of Overexposure: May lead to mild nausea, vomiting, aches, or skin rash in high exposures
Ecotoxicity: Very toxic to aquatic invertebrates, chronic impact on aquatic organisms possible
Persistence and Degradability: High potential for persistence due to slow breakdown in soil and water
Bioaccumulation Potential: Possibility of bioaccumulation in aquatic environments, watch for run-off into waterways
Mobility in Soil: Tends to adsorb to soil particles, limited mobility in most environments
Other Adverse Effects: Not expected to have volatile emissions, but risk to bees and non-target insects in contaminated areas exists
Product Disposal: Dispose unused material as hazardous waste by incineration or appropriate chemical disposal methods consistent with local laws
Container Disposal: Triple rinse and offer for recycling if facilities exist, otherwise dispose with product waste
Precautions: Avoid unauthorized release to the environment, discourage disposal in household trash or sinks
Contaminated Packaging: Handle empty containers as for highly toxic materials until cleaned
UN Number: Not classified as a hazardous material for transport by most international standards
Proper Shipping Name: Not regulated, consult with carrier for large-scale shipments
Hazard Class: Not applicable
Packaging Group: Not assigned
Special Precautions: Protect from excess heat, moisture, and rough handling during transit
OSHA Status: Not specifically regulated, general industry safety practices apply
EPA Status: Registered veterinary medicine, restricted to professional or prescription-only distribution
TSCA Status: Subject to review, refer to specific jurisdiction
International: Consult regional regulators regarding approval status and any unique national import, export, or environmental restrictions
Labeling: Must carry hazard warning about accidental exposure and potential environmental effects
