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Adenosine (Chemical Synthesis) Material Safety Data Sheet

Identification

Chemical Name: Adenosine
CAS Number: 58-61-7
Synonyms: 6-Amino-9-beta-D-ribofuranosyl-9H-purine
Recommended Use: Laboratory chemical, chemical synthesis, production of pharmaceuticals
Manufacturer: Provided by laboratory or supplier
Emergency Contact: Refer to supplier's contact details and local emergency telephone number
Address: Refer to supplier’s information or laboratory address
Email: Supplied by laboratory or manufacturing source

Hazard Identification

GHS Classification: Not classified as hazardous according to current GHS criteria
Main Hazards: Potential for irritation following direct contact with eyes, skin, or mucous membranes; inhalation of dust may lead to respiratory tract irritation
Pictograms: No pictogram assigned
Signal Word: None assigned
Hazard Statements: Possible mild irritation to skin and eyes, ingestion may cause gastrointestinal discomfort
Precautionary Statements: Avoid generating dust; use PPE to prevent skin and eye contact; keep away from food and drink; wash hands thoroughly after handling
Other Hazards: May cause temporary discomfort with prolonged contact; dust generation could pose minor nuisance

Composition / Information on Ingredients

Substance: Adenosine
Purity: >98% (typical laboratory grade)
Molecular Formula: C10H13N5O4
Molecular Weight: 267.24 g/mol
Impurities: Negligible, not expected to contribute additional hazards under normal laboratory conditions
Ingredient List: No hazardous stabilizers or additives present

First Aid Measures

Inhalation: Move affected person to fresh air; seek medical attention if respiratory symptoms develop
Skin Contact: Wash area with soap and water; remove contaminated clothing; seek medical advice if irritation persists
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if present and easy to do; seek medical care if irritation continues
Ingestion: Rinse mouth; seek medical advice if any discomfort occurs; never give anything by mouth to an unconscious person
Symptoms and Effects: May experience mild irritation, redness, or transient discomfort; prolonged exposure rarely causes pronounced effects
Recommendations for Medical Attention: Treat symptoms; supportive care as needed based on exposure and clinical judgment

Fire-Fighting Measures

Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, or water spray; foam can be used for larger fires
Unsuitable Media: None expected for this material
Special Hazards: Thermal decomposition releases nitrogen oxides and carbon oxides; dust in air may present minimal explosion risk in confined spaces
Firefighter Protection: Wear self-contained breathing apparatus and full protective clothing; avoid inhalation of combustion byproducts
Firefighting Procedures: Move containers away from fire area if safely possible; avoid run-off entering drains and water sources; control firefighting water

Accidental Release Measures

Personal Precautions: Avoid generating dust; use respiratory protection if dust becomes airborne; prevent skin and eye contact
Environmental Precautions: Prevent large quantities from entering drains, groundwater, or surface water systems; report spills to authorities as required
Methods for Clean-Up: Sweep up material with care to avoid dust formation; collect in clearly labeled containers for disposal; wash spill area with water
Decontamination: Clean equipment and surfaces with water; ensure adequate ventilation in affected area

Handling and Storage

Handling: Work in a well-ventilated area; use local exhaust if dust formation occurs; avoid contact with skin, eyes, and clothing; wash hands after use; no eating, drinking, or smoking in work area
Storage Conditions: Store in tightly closed container; keep in a cool, dry, and well-ventilated space; protect from moisture and incompatible substances; store away from oxidizing agents
Incompatible Materials: Strong oxidizers, strong acids
Storage Temperature: Room temperature, ideally between 2-8°C to maintain stability

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits specified
Engineering Controls: Use local exhaust or general ventilation to maintain airborne concentrations below recommended limits
Personal Protective Equipment: Safety glasses with side shields or goggles; chemical-resistant gloves; laboratory coat or apron; use dust mask if ventilation is inadequate or if dust becomes airborne
Hygiene Measures: Avoid direct contact; wash thoroughly after handling; change contaminated clothing
Environmental Controls: Minimize release to environment; maintain spill control equipment in work area

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: 5.0-7.0 (1% solution in water)
Melting Point: 234-236°C (decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not considered flammable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: 1.60-1.80 (g/cm³)
Solubility: Slightly soluble in water; insoluble in most organic solvents
Partition Coefficient (log Kow): Not available
Auto-Ignition Temperature: No data available
Decomposition Temperature: 234°C
Other Properties: Stable under recommended storage conditions

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and storage conditions
Reactivity: No known hazardous reactions under normal use
Conditions to Avoid: Excess moisture, strong heat, and incompatible materials
Incompatible Materials: Strong oxidizing agents, acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Will not occur

Toxicological Information

Acute Toxicity: Data limited; low acute toxicity in laboratory animal studies
Skin Irritation: Mild possible irritation from repeated or prolonged contact
Eye Irritation: Minor irritation; not classified as a serious eye irritant
Respiratory Sensitization: Inhalation of dust can irritate airways; sensitization not reported
Gastrointestinal Effects: May cause minor discomfort if ingested in significant amounts
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: Not identified as mutagenic by available studies
Reproductive Effects: No known reproductive toxicity based on available data
Additional Information: Handle using good laboratory practices to avoid undue exposure

Ecological Information

Ecotoxicity: Not classified as hazardous for aquatic environments; low potential for bioaccumulation or ecotoxic effects
Persistence and Degradability: Expected to degrade under normal environmental conditions
Bioaccumulation Potential: Low, based on physical-chemical properties
Mobility in Soil: Low, as compound exhibits limited solubility in water
Other Adverse Effects: Not expected to contribute to environmental harm under typical laboratory use; large spills may affect aquatic life due to oxygen demand

Disposal Considerations

Waste Disposal Methods: Dispose in accordance with local, state, and national regulations; typically classified as non-hazardous laboratory waste unless contaminated
Container Disposal: Clean containers should be recycled or disposed in line with applicable laws
Precautions: Do not allow to enter drains or watercourses in large quantities
Other Information: Follow institutional protocols and guidelines for chemical disposal

Transport Information

UN Number: Not classified as hazardous for transport
Transport Hazard Class: Not regulated as dangerous goods under ADR, IMDG, IATA, DOT
Packing Group: Not applicable
Labeling: Standard laboratory labeling; no additional transport hazard symbols required
Special Precautions: Avoid mechanical damage to containers; prevent release of dust during handling and transport

Regulatory Information

TSCA Status: Article or substance may be listed in the Toxic Substances Control Act inventory
REACH Registration: Pre-registered or registered where relevant under European Community regulations
Hazard Symbols: Not assigned
SARA Section 313: Not listed
California Prop 65: Not listed as causing cancer, birth defects, or other reproductive harm
Other Regulatory Listings: Not classified as hazardous under OSHA Hazard Communication Standard
Workplace Restrictions: Use and handling should meet institutional and national safety requirements