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Material Safety Data Sheet for Adenine (Vitamin B4)

Identification

Product Name: Adenine
Synonyms: 6-Aminopurine, Vitamin B4
Chemical Formula: C5H5N5
CAS Number: 73-24-5
Intended Use: Research, laboratory, pharmaceutical applications
Manufacturer: Reference company’s name and address on individual container label
Emergency Contact: Refer to local poison control center or emergency services number printed on shipping label

Hazard Identification

Hazard Classification: Not classified as hazardous under GHS criteria. Handling large quantities may cause irritation.
Routes of Exposure: Eyes, skin, inhalation, ingestion
Signal Word: None
Hazard Statements: May cause mild irritation to eyes, skin, or respiratory tract. Low toxicity if swallowed. No confirmed carcinogenicity.
Pictograms: None required
Precautionary Statements: Avoid dust formation and contact with skin or eyes. Use only in well-ventilated areas. Wear recommended protective equipment.

Composition / Information on Ingredients

Chemical Name: Adenine
Concentration: ≥99% pure
CAS Number: 73-24-5
Additional Components: None present in significant quantity. Trace impurities below reportable thresholds.

First Aid Measures

Eye Contact: Gently rinse eyes with plenty of water for 15 minutes while lifting eyelids. Remove contact lenses if present and easy to do. Seek medical attention for continuing irritation.
Skin Contact: Wash exposed area with soap and water. Remove contaminated clothing. Seek medical help if irritation persists.
Inhalation: Move to fresh air. If breathing becomes difficult, get immediate medical assistance.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Call a physician if unwell or large amount consumed.
Most Important Symptoms: Irritation, redness, or discomfort in affected area. No known serious acute or delayed effects.

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide.
Unsuitable Media: Do not use water jet for direct stream.
Specific Hazards: Emits toxic nitrogen oxides and carbon oxides upon combustion. Fine dust may pose explosion hazard in air.
Protective Equipment: Full protective gear and self-contained breathing apparatus recommended for firefighters.
Special Procedures: Move containers away from fire area if safe to do so. Avoid inhaling downwind gases or fumes.

Accidental Release Measures

Personal Protection: Wear gloves, goggles, a dust mask or respirator if airborne particles become a concern.
Environmental Precautions: Avoid release to drains, soil, or surface waters.
Spill Cleanup: Sweep up or vacuum without generating dust. Place waste in closed containers for disposal.
Decontamination: Wash spill area with water after product removal. Ventilate site thoroughly before reoccupying.

Handling and Storage

Handling: Use with adequate ventilation. Minimize dust generation. Do not eat, drink, or smoke around product.
Protection: Use proper personal protective equipment. Handle with care to avoid exposure.
Storage Conditions: Store tightly closed in cool, dry, well-ventilated place. Keep away from acids, oxidizers, heat, or flame.
Incompatibilities: Strong oxidizing agents, strong bases, and acids may cause reaction.
Other Precautions: Label containers appropriately. Store separately from food or feedstuffs.

Exposure Controls and Personal Protection

Engineering Controls: Use fume hoods or local exhaust when available to limit airborne dust. Maintain workplace hygiene.
Respiratory Protection: Wear dust mask (N95 or equivalent) if ventilation cannot eliminate airborne hazard.
Eye Protection: Chemical-resistant safety goggles or glasses
Skin Protection: Disposable gloves (nitrile or latex), lab coat, long sleeves
Exposure Limits: No OSHA, NIOSH, or ACGIH exposure limits established for adenine.
General Hygiene: Wash hands after handling. Remove and wash contaminated clothing before reuse.

Physical and Chemical Properties

Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Melting Point: Around 360°C (sublimes)
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water (about 1g/L at 25°C)
Molecular Weight: 135.13 g/mol
pH: Slightly basic (in water)
Vapor Pressure: Negligible
Density: Not established, estimated around 1.6-1.7 g/cm³
Flash Point: Not flammable under conventional circumstances
Partition Coefficient: No data available
Auto-ignition Temperature: Not available

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures. Avoid prolonged exposure to heat and sunlight.
Conditions to Avoid: Excessive dust formation, sources of ignition, incompatible substances.
Incompatible Materials: Oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides under fire conditions.
Hazardous Reactions: Will not polymerize or react violently under standard storage.

Toxicological Information

Acute Toxicity: Low toxicity in animal studies. Large quantities by oral route may cause mild digestive disturbance.
Chronic Toxicity: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available literature.
Routes of Exposure: Eyes, skin, ingestion, inhalation
Symptoms: Irritation of eyes, skin, mucous membranes.
Sensitization: Not a known sensitizer.
Target Organs: No specific target organ toxicity.
Reference Studies: Animal LD50 (rat, oral): > 2,000 mg/kg (very low toxicity range)

Ecological Information

Toxicity: Not classified as hazardous to aquatic life. Degrades naturally in the environment.
Persistence and Degradability: Biodegradable under aerobic conditions.
Bioaccumulation: Not expected due to low partition coefficient.
Mobility in Soil: High water solubility leads to moderate mobility.
Other Adverse Effects: None identified based on available research.

Disposal Considerations

Waste Disposal Methods: Dispose of contents in accordance with local, regional, national, and international regulations applicable to laboratory chemicals.
Container Disposal: Triple rinse and dispose of empty packaging as chemical waste or per municipal requirements.
Environmental Precautions: Prevent release to sewers, waterways, or soil. Do not incinerate in open air.

Transport Information

UN Number: Not regulated under ADR, IMDG, IATA
Proper Shipping Name: Adenine
Transport Hazard Class: Not classified as hazardous for transport
Packing Group: Not applicable
Special Precautions: Use original packaging or chemical-resistant containers. Secure in transport to avoid breakage and spillage.

Regulatory Information

GHS Classification: Not classified as hazardous
OSHA Status: Not listed as hazardous under OSHA regulations
SARA Title III: Not subject to reporting
TSCA Inventory: Listed
EU Classification: Not classified as dangerous under Regulation (EC) No. 1272/2008
Other Applicable Laws: Comply with all relevant local, state, and federal environmental and safety regulations at point of use or disposal.