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Product Name: Actarit
Chemical Name: 4-Acetamidophenylacetic Acid
CAS Number: 18699-02-0
Formulation: Pure active pharmaceutical ingredient, also found in tablet forms
Supplier Details: Pharmaceutical manufacturers and research labs
Recommended Use: Disease-modifying anti-rheumatic drug (DMARD)
Common Synonyms: N-(4-(Carboxymethyl)phenyl)acetamide
UN Number: Not classified for transport
Emergency Contact: Refer to chemical supplier or national poison center
Hazard Class: Not classified as hazardous under GHS for normal handling
Potential Health Effects: Mild skin and eye irritation; ingestion can cause gastrointestinal distress
Pictogram: None under GHS; still, care needed for dust generation
Signal Word: Caution
Possible Routes of Exposure: Inhalation, ingestion, skin and eye contact
Specific Hazards: May cause allergic skin reaction in sensitive individuals
Chemical Identity: Actarit
Concentration: 98–100% for pure substance
Impurities: Trace manufacturing by-products possible, minimal levels present
Molecular Formula: C10H11NO3
Molecular Weight: 193.2 g/mol
Inhalation: Remove to fresh air, seek medical attention for persistent symptoms
Skin Contact: Wash with soap and water, remove contaminated clothing
Eye Contact: Rinse cautiously with water for at least 15 minutes; consult a physician if irritation persists
Ingestion: Rinse mouth, seek medical attention if feeling unwell
Note for Physicians: Symptomatic treatment recommended, no specific antidote known
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Fire and Explosion Hazards: Product is not highly flammable, dust may form explosive mixtures if airborne
Protective Equipment: Use self-contained breathing apparatus and protective garments
Special Procedures: Prevent runoff from entering waterways, use appropriate extinguishing protocols
Thermal Decomposition: May release CO, CO2, nitrogen oxides, and irritating fumes
Personal Protection: Wear gloves, protective eyewear, mask to avoid dust inhalation
Environmental Precautions: Prevent large spills from entering drains or water bodies
Clean-Up Methods: Collect spillage using a vacuum with a HEPA filter or sweep up carefully; avoid generating dust; store recovered material for disposal
Protective Actions: Isolate area, ventilate if necessary, contain spill to prevent spreading
Safe Handling: Avoid contact with eyes, skin, and clothing; wash hands thoroughly after handling
Avoid: Generating dust, eating, drinking, or smoking near handling area
Storage Conditions: Store in a well-ventilated area, in tightly sealed containers, away from incompatible materials and direct sunlight
Storage Temperature: Room temperature, keep away from moisture
Incompatible Materials: Strong oxidizing agents
Control Parameters: Occupational exposure limit not established for Actarit
Engineering Controls: Local exhaust, enclosure, and proper ventilation when handling powders
Personal Protection – Skin: Nitrile or latex gloves
Personal Protection – Eyes: Chemical safety goggles
Personal Protection – Respiratory: Dust mask or N95 respirator if dust concentration increases
Hygiene Measures: Wash hands, remove contaminated clothing directly after handling
Appearance: White crystalline powder
Odor: Odorless
Melting Point: 154–156°C
Solubility: Slightly soluble in water, more soluble in ethanol and methanol
Boiling Point: Not determined due to decomposition
Vapor Pressure: Not significant at ambient conditions
pH (1% aqueous solution): Slightly acidic
Density: About 1.3 g/cm³
Partition Coefficient: LogP value: approximately 1.5
Flash Point: Not flammable under normal use
Chemical Stability: Stable under recommended storage conditions and normal handling
Reactivity: No dangerous reactions under normal conditions
Conditions to Avoid: Strong heating, excessive moisture, exposure to sunlight
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, toxic fumes formed on burning
Acute Toxicity: Low toxicity based on animal data; oral LD50 (rat): above 2000 mg/kg
Skin Irritation: Mild, not a strong irritant
Eye Irritation: May cause transient redness or discomfort
Respiratory Effects: Inhalation of dust may irritate mucous membranes
Chronic Exposure: Long-term data limited; as a pharmaceutical, used under medical supervision
Sensitization: Possible in some individuals; rare reports of allergic response
Carcinogenicity/Mutagenicity: No evidence in standard testing, not listed on IARC or NTP
Reproductive Toxicity: No significant evidence in animal studies
Ecotoxicity: Not expected to be highly toxic to aquatic life; precise data limited
Biodegradability: Data on environmental degradation unavailable; similar compounds show slow breakdown
Bioaccumulative Potential: Low, based on molecular structure and solubility
Mobility in Soil: Low, tendency to bind to soil particles
Persistence: May persist in water and soil without complete rapid breakdown
Aquatic Impact: Avoid large release to sewers and waterways to limit ecological risk
Waste Treatment Methods: Collect in sealed, labelled containers; incinerate in controlled facility
Regulatory Status: Not classified as hazardous waste, but best practices recommend treating as pharmaceutical waste
Sewage Disposal: Avoid direct disposal in municipal sewage systems
Contaminated Packaging: Rinse and dispose through authorized waste handler
Disposal Precautions: Follow local, regional, and national regulations for pharmaceuticals
UN Number: Not regulated
ADR/RID: Not regulated
IMDG: Not regulated
IATA: Not regulated
Special Precautions: Ship in tightly sealed containers; shield from direct sunlight, moisture, and excessive heat
Handling During Transport: Use secure containers to prevent leakage and contamination
Europe: Not classified as hazardous under EU regulations; not subject to specific registration requirements
United States: Not listed on the TSCA inventory; intended for pharmaceutical use only
Japan: Follows local pharmaceutical safety regulations
Occupational Safety: No occupational exposure limits set
Labelling: Contains Actarit, handle according to pharmaceutical standards
Other National Regulations: Observe workplace safety and chemical use procedures as set by local authorities
