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Chemical Name: 4-Bromophenylacetyl Bromide
Synonyms: p-Bromophenylacetyl Bromide, 2-Bromo-1-(4-bromophenyl)ethanone
CAS Number: 703-91-3
Recommended Use: Intermediate in organic synthesis
Manufacturer: Consult chemical supplier documentation
Emergency Telephone: Refer to local poison control or emergency center
Address: Manufacturer or distributor details should be verified on the container label.
Email: Supplier or manufacturer support contact as listed on the packaging.
Hazard Class: Corrosive, Irritant
Signal Word: Danger
Hazard Statements: Causes serious skin burns and eye damage; may cause respiratory irritation; toxic if inhaled or swallowed
Pictograms: Corrosive, Health hazard (GHS06, GHS05)
Precautionary Statements: Avoid breathing fumes, prevent contact with skin and eyes, use only in well-ventilated areas, wear protective equipment
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Effects: Severe irritation or burns to mucous membranes, respiratory distress, possible systemic toxicity upon significant exposure
Chronic Effects: Prolonged or repeated exposure may lead to dermatitis, respiratory issues, or organ damage; no known carcinogenicity data
Chemical Identity: 4-Bromophenylacetyl Bromide
Common Name: As above
CAS Number: 703-91-3
Purity: Over 95% (technical or purified grades; impurities considered negligible for routine laboratory safety assessment)
EC Number: 627-799-5
Molecular Formula: C8H6Br2O
Molecular Weight: 277.95 g/mol
Hazard Impurities: Minor brominated or acetylated by-products (consult batch-specific COA if available)
General Advice: Remove contaminated clothing and shoes immediately. Seek medical attention after exposure.
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Skin Contact: Wash affected area with soap and water for at least 15 minutes; seek immediate medical attention.
Inhalation: Move person to fresh air. If not breathing, provide artificial respiration; get medical help right away.
Ingestion: Do not induce vomiting. Rinse mouth with water. Seek medical attention quickly.
Symptoms: Burning sensation, coughing, shortness of breath, pain, redness, blistering
Special Clinical Care: Treat symptomatically and supportively; monitor for delayed pulmonary edema
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Media: Do not use strong water jets, which could scatter spilled material.
Special Hazards: Releases toxic vapors under fire conditions including hydrogen bromide, carbon monoxide, carbon dioxide
Firefighting Instructions: Evacuate area. Wear self-contained breathing apparatus and protective clothing.
Explosion Data: No known explosion hazard if handled appropriately; potential violent reaction with strong bases or oxidizers
Combustion Products: Bromine-containing vapors, acidic gases.
Personal Precautions: Wear appropriate PPE: gloves, safety goggles, lab coat, respirator for vapor/fume risk.
Environmental Precautions: Prevent further leakage or spillage if safe. Do not let product enter drains or freshwater resources.
Containment: Limit spread using non-combustible absorbent materials like vermiculite or sand.
Cleanup Methods: Collect in suitable, labeled containers for disposal. Ventilate area and wash surfaces thoroughly after clean up.
Reporting: Notify responsible authorities if significant environmental release occurs.
Handling: Avoid contact with skin, eyes, and clothing. Use only in a chemical fume hood. Avoid inhalation of vapor or mist.
Hygiene Measures: Wash hands after handling; remove contaminated clothing before entering eating areas.
Storage: Store tightly closed in a cool, dry, well-ventilated, corrosion-resistant area.
Segregation: Store separate from oxidizing agents, bases, water, moisture, acids.
Packaging: Use airtight, glass or chemical-resistant containers recommended by suppliers.
Engineering Controls: Chemical fume hood, eyewash station, and emergency shower should be present wherever the compound is used.
Exposure Limits: No specific regulatory occupational exposure limit value available; minimize exposure according to best practice.
Respiratory Protection: Use NIOSH/MSHA approved respirators with acid gas cartridges if handling outside of fume hood.
Hand Protection: Chemical-resistant gloves (nitrile, neoprene, or equivalent).
Eye Protection: Chemical splash goggles; face shield for large volume use.
Skin Protection: Long-sleeved lab coat, chemical-resistant apron, closed-toe shoes.
Environmental Exposure Controls: Use containment and ensure all spills and wastes are properly managed.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, sharp, acrid
Melting Point: < 15°C (literature variable, may solidify under refrigeration)
Boiling Point: 145–148°C at 13 mmHg (decomposes and fumes)
Flash Point: Not established, presumed combustible
Vapor Pressure: Relatively low at ambient temperature
Solubility: Reacts with water; soluble in organic solvents like dichloromethane, chloroform, toluene
Density: Approximately 1.7 g/cm³
Molecular Weight: 277.95 g/mol
Stability: Hydrolyzes in presence of moisture
pH: Not applicable
Chemical Stability: Stable in tightly closed containers under inert atmosphere
Reactivity: Reacts violently with water, alcohols, amines, strong bases
Conditions to Avoid: Exposure to air, moisture, heat, and incompatible chemicals
Incompatible Materials: Water, strong bases, strong oxidizing agents, alcohols, amines
Hazardous Decomposition Products: Hydrogen bromide, bromine, carbon monoxide, carbon dioxide
Polymerization: No hazardous polymerization expected
Acute Toxicity: Highly toxic by ingestion, inhalation, and skin absorption; no definitive LD50 data for humans, rat oral LD50 (est.): 100-300 mg/kg
Skin Corrosion/Irritation: Severe burns, pain, blisters on contact
Eye Effects: Severe, possibly irreversible injury on direct contact
Respiratory Effects: Irritation, coughing, bronchospasm, possible pulmonary edema on high level inhalation
Ingestion Effects: Corrosive burns, nausea, vomiting, abdominal pain
Chronic Exposure Risks: Skin sensitization, chronic dermatitis, possibly respiratory tract irritant sensitization
Carcinogenicity/Mutagenicity: No substantial data; not classified by IARC, NTP, OSHA
Target Organs: Skin, eyes, respiratory system
Toxicity: Toxic to aquatic life; may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Hydrolyzes in the environment to form acids and brominated by-products
Bioaccumulation Potential: Expected to have low bioaccumulation due to instability and high reactivity
Mobility in Soil: Likely to undergo rapid hydrolysis to less mobile products
Other Environmental Hazards: Avoid release to natural water sources; use containment and proper waste management procedures
Disposal Methods: Dispose of via licensed chemical waste contractor. Do not pour into drains or the environment.
Container Disposal: Triple rinse containers with compatible solvent before disposal; dispose of empty packaging as hazardous chemical waste.
Special Precautions: Neutralize residue before disposal, ensure compliance with local, regional, and national regulations
Regulatory Waste Classification: Classified as hazardous waste (reactive, toxic, corrosive)
Incineration: Permitted only in chemical incinerators equipped for halogenated waste
UN Number: 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains 4-Bromophenylacetyl Bromide)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labels Required: Corrosive
Environmental Hazards: Marine pollutant
Special Precautions: Keep containers upright and tightly sealed during transport, handle with protective measures to prevent leaks or spills
Transport in bulk: Not recommended outside of approved bulk containers
DOT/IATA/IMDG Regulations: Subject to detailed hazardous materials transport requirements; check current year booking for full compliance
TSCA Status: Listed in the US Toxic Substances Control Act inventory
EINECS/ELINCS Status: Listed under EC number 627-799-5
SARA Title III: Not specifically listed, but all releases subject to SARA reporting if EPA threshold is met
California Proposition 65: No specific listing, but state law on hazardous chemicals applies
GHS Classification: Skin Corr. 1B, Acute Tox. 3 (Inhalation), Acute Tox. 3 (Oral)
Workplace Labeling: Comply with OSHA Hazard Communication Standard 29CFR1910.1200
Other Local Regulations: Users should check national and regional legislation on chemical safety and environmental protection
WHMIS (Canada): Class E (Corrosive), D1B (Toxic Material Causing Immediate and Serious Toxic Effects). Handle with strict adherence to local safety program
