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Product Name: Acetaminophen Chemical Formula: C8H9NO2 CAS Number: 103-90-2 Synonyms: Paracetamol, 4-Acetamidophenol Manufacturer/Distributor: Refer to the actual supplier on shipment documentation Emergency Phone Number: Refer to local country-specific poison control and manufacturer contact Intended Use: Analgesic, Antipyretic Recommended Use Restrictions: Strictly for medical, pharmaceutical, and laboratory applications under regulatory authorization
Globally Harmonized System Classification: Not classified as hazardous under GHS for normal use Primary Health Hazards: Overexposure can cause liver damage, kidney damage, and allergic reactions in sensitive individuals Route of Exposure: Inhalation of dust, dermal absorption, ingestion Target Organs: Liver, Kidneys Signal Word: None required for typical preparations, caution with bulk raw chemical Precautionary Statements: Wash exposed skin thoroughly; avoid contact with eyes and prolonged exposure Hazard Symbol: No pictogram generally assigned, though misuse can pose significant health risks
Chemical Name: 4'-Hydroxyacetanilide Molecular Weight: 151.16 g/mol Ingredients: Acetaminophen, possible trace substances from manufacturing such as starting reagents or process solvents (typically tightly controlled below regulatory thresholds for pharmaceuticals) Purity: Typically >99% for pharmaceutical grade
Inhalation: Move person to fresh air, monitor for respiratory symptoms, consult healthcare provider if persistent irritation or systemic effects appear Skin Contact: Remove contaminated clothing, wash affected skin with mild soap and water, seek medical advice for irritation Eye Contact: Rinse eyes under gentle running water for several minutes, remove contact lenses if present, obtain medical assessment if discomfort continues Ingestion: Seek medical attention if large quantities swallowed or symptoms (nausea, vomiting, abdominal pain) develop—do not induce vomiting unless instructed by medical personnel Acute Symptoms: Sweating, jaundice, confusion, vomiting after large overdose may signal liver injury and require emergency care
Suitable Extinguishing Media: Use dry chemical, foam, CO2, or water spray Special Hazards: Decomposition at elevated temperatures may yield toxic fumes like nitrogen oxides and carbon monoxide Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear Special Procedures: Cool containers with water from a safe distance; prevent contaminated water runoff into drains
Personal Precautions: Minimize dust generation, use appropriate PPE including gloves, eye protection, and a dust mask if necessary Environmental Precautions: Prevent spillage from entering drains, waterways, or soil Cleanup Methods: Sweep up material carefully and place in a labeled, sealed waste container; ventilate area and wash residue with water after collecting spilled powder Disposal: Dispose of collected waste following local regulations for pharmaceutical chemical waste
Handling: Use local exhaust ventilation for bulk material transfers; handle in a well-ventilated area; avoid creating or breathing dust Storage Conditions: Store in tight, light-resistant containers under cool, dry conditions; avoid moisture and heat sources Segregation: Keep away from incompatible or reactive substances like strong oxidizers Personal Hygiene: Wash hands before eating, drinking, or smoking after handling the substance
Occupational Exposure Limit: No specific OSHA PEL or ACGIH TLV but minimize workplace exposure with general dust limits (<10 mg/m3; nuisance dust) Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits Personal Protective Equipment: Safety goggles, nitrile or latex gloves, lab coat or apron, NIOSH-approved dust respirator for bulk dust handling Workplace Hygiene Measures: Prohibit eating, drinking, or smoking in processing areas, provide eyewash stations and safety showers
Appearance: White or slightly off-white crystalline powder Odor: Odorless Solubility: Slightly soluble in water, freely soluble in boiling water, soluble in alcohol Melting Point: 168°C to 172°C Boiling Point: Not readily available, decomposes prior to boiling Vapor Pressure: Negligible under ambient conditions pH: Slightly acidic (5-6.5) in aqueous suspension Density: About 1.293 g/cm3 Partition Coefficient (log Pow): 0.46 Stability in Light: Stable under recommended storage, sensitive to strong light and heat
Chemical Stability: Stable at room temperature under recommended storage Reactivity: Non-reactive under normal conditions Incompatible Materials: Strong oxidizing agents, strong acids, alkalis Decomposition Products: At high temp, emits toxic fumes - nitrogen oxides, carbon monoxide Risk of Hazardous Reactions: No hazardous polymerization expected
Acute Toxicity: Oral LD50 (rat): approx. 338 mg/kg; LD50 (mouse): approx. 338 mg/kg Chronic Toxicity: Repeated overuse linked to hepatotoxicity, nephrotoxicity, and rare blood disorders Carcinogenicity: Not considered carcinogenic by IARC, NTP, OSHA Reproductive Toxicity: No clear evidence at therapeutic dosages, but overdoses or abuse could impact fetal development Potential Health Effects: Liver damage in overdose scenarios, skin rashes, allergic reactions Other Data: Therapeutic doses considered safe; caution for those with preexisting liver conditions
Mobility: Limited mobility in soil due to low solubility, yet can leach if present in large amounts Degradation: Partially degradable; undergoes breakdown by microbes in wastewater treatment plants, though some persistence seen Aquatic Toxicity: Not highly toxic to aquatic life in trace quantities but releases in bulk amounts can disturb aquatic ecosystems Bioaccumulation: Low potential due to low log Pow Environmental Precautions: Avoid large releases into environment; monitor effluent from pharmaceutical manufacturing
Disposal Methods: Incinerate in approved facility or dispose by landfill following all local environmental regulations, do not discard in household trash Contaminated Packaging: Triple rinse and offer for recycling or reconditioning if possible; otherwise, treat as hazardous waste Special Precautions for Landfill/Incineration: Prevent release to watercourses by secure containment during transport and storage at disposal site
UN Number: Not regulated as hazardous material for ground, air, or sea transport under most jurisdictions Proper Shipping Name: Acetaminophen Hazard Class: Not assigned Packing Group: Not assigned Transport Precautions: Avoid contamination with strong oxidizers or incompatibles during shipment, use secure packaging to prevent leaks
Labeling Requirements: No hazard pictogram for small quantities in finished dosage form; must comply with drug labeling standards and country-specific pharmaceutical controls Drug Scheduling: Non-prescription in many countries but restrictions apply for bulk chemical handling Inventory Status: Listed on TSCA, EINECS, DSL Other Regulatory Notes: Subject to FDA, EMA, and other governing bodies for pharmaceuticals; occupational chemical controls apply for manufacturing sector Community Right-to-Know Act: Not a listed hazardous substance but best practice is to maintain clear MSDS records and train personnel handling bulk powder
