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Product Name: Acemetacin
Chemical Formula: C21H18ClNO6
Synonyms: 4-chloro-N-(2-oxo-2H-1-benzopyran-3-yl)benzamide glycolic acid ester, Aceclofenac Glycolic Acid Ester
Manufacturer: Refer to product label or supplier
Recommended Use: Nonsteroidal anti-inflammatory drug (NSAID); research and pharmaceutical applications
Emergency Contact: Refer to local poison control center or emergency medical responder
Cas Number: 53164-05-9
Hazard Classification: Harmful if swallowed, may cause damage to organs through prolonged or repeated exposure, irritant to eyes and skin
Signal Word: Warning
Hazard Statements: May cause allergic reactions, possible risk of gastrointestinal ulcers or bleeding, may trigger asthma in sensitive individuals
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Avoid contact with eyes and skin; avoid inhaling dust or fumes; wash hands thoroughly after handling; use personal protective equipment as required
Chemical Name: Acemetacin
Purity: Typically > 98%
Impurities: Related compounds < 2%
Molecular Weight: 415.83 g/mol
Other Ingredients: None within pharmaceutical grade; consult supplier for excipients in formulated products
Inhalation: Move person to fresh air, seek medical attention if symptoms occur
Ingestion: Rinse mouth, never give anything by mouth if unconscious, seek immediate medical assistance
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, get medical attention if irritation persists
Eye Contact: Flush eyes gently with water for several minutes, remove contact lenses if present and easy to do, get medical evaluation
Note to Physicians: Treat symptomatically, monitor for gastrointestinal or allergic complications
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Direct water jet if large spill; may spread powder
Fire Hazards: Combustion forms toxic fumes such as nitrogen oxides, chlorine, hydrogen chloride, carbon oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, chemical resistant gloves and suit
Special Hazards: Powder dust may form explosive mixtures with air under high concentrations
Personal Precautions: Use personal protective equipment, avoid inhaling powders or dusts
Environmental Precautions: Prevent further leakage or spillage, do not allow to enter drains, surface water, or soil
Methods for Cleaning Up: Sweep up carefully to avoid dust formation, place in secure chemical waste container, wipe with damp cloth, neutralize residue with appropriate cleaner
Reference to Other Sections: Refer to sections on handling, storage, and disposal for additional guidance
Precautions for Safe Handling: Handle in well-ventilated environments, use safety goggles and chemical-resistant gloves, avoid generating dust, practice good industrial hygiene
Storage Conditions: Store in tightly closed original container, away from light, heat sources, and incompatible substances such as strong oxidizing agents
Storage Temperature: Room temperature, between 15°C and 25°C, keep dry
Incompatibilities: Avoid strong acids, bases, oxidizing agents
Special Storage Requirements: Clearly labeled containers, lockable storage recommended in research or medical settings
Exposure Limits: Occupational limits are not established specifically for Acemetacin—minimize exposure as good practice
Engineering Controls: Work in fume hood or well-ventilated area, use dust extraction for powder handling
Personal Protective Equipment: Chemical-resistant gloves, lab coat, eye protection (goggles), dust mask or respirator when handling powders
Hygiene Measures: Wash hands thoroughly after handling, avoid eating, drinking, or smoking in work areas, change contaminated clothing promptly
Appearance: White to off-white crystalline powder
Odor: Odorless or slight characteristic odor
pH (solution): Not applicable, insoluble in water
Solubility: Partially soluble in organic solvents such as methanol, ethanol, DMSO
Melting Point: Range of 190–195°C
Boiling Point: Decomposes before boiling
Vapor Pressure: Not measurable at ambient conditions
Flash Point: Not established—considered non-volatile
Partition Coefficient: logP ~3.4
Density: Approximately 1.42 g/cm³
Reactivity: Not reactive under recommended storage and handling conditions
Chemical Stability: Stable under ambient conditions if unopened
Hazardous Reactions: No dangerous reactions known if used as intended
Decomposition Products: Produces carbon monoxide, carbon dioxide, nitrogen oxides, and hydrochloric acid when heated strongly
Polymerization: No hazardous polymerization expected
Acute Toxicity: Harmful if swallowed; oral toxicity (rat) estimated at LD50 > 150 mg/kg
Skin Corrosion/Irritation: May cause mild irritation on prolonged contact
Eye Damage/Irritation: May induce transient eye irritation
Respiratory Sensitization: Dust may trigger reactions in sensitive individuals
Chronic Effects: May affect liver and kidneys after prolonged exposure; gastrointestinal ulceration risk
Carcinogenicity: No evidence of carcinogenic potential in available studies
Reproductive Toxicity: Not recommended during pregnancy or breastfeeding due to effects on fetal health—based on class effects for NSAIDs
Additional Information: Common NSAID side effects such as gastrointestinal distress and allergic skin rash can occur
Toxicity to Aquatic Life: Harmful to fish, invertebrates, and algae even at low concentrations
Persistence & Degradability: Not readily biodegradable in the environment
Bioaccumulative Potential: Moderate potential for bioaccumulation found in experimental models
Mobility in Soil: Limited mobility owing to poor water solubility, risk of accumulation near point of discharge
Environmental Precautions: Do not discharge into drains, water courses, or soil; may pose hazard to aquatic ecosystems
Waste Disposal Methods: Collect for chemical waste disposal via licensed hazardous waste contractor
Unused Product: Incinerate at high temperature in authorized facility, review local regulations for pharmaceutical waste
Contaminated Packaging: Dispose as chemical waste; triple rinse containers; follow local regulations for hazardous material disposal
Environmental Impact: Prevent large quantities from entering the environment or sewage systems
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Not regulated by ADR/RID/IMDG/IATA
Transport Hazard Class: Non-hazardous; pack securely to prevent release of powder
Packing Group: Not assigned
Special Precautions for Transport: Keep container tightly closed; avoid damage or spillage during shipment
International Regulation: Controlled substance regulations apply as per local jurisdiction for pharmaceuticals
United States: Not listed under OSHA HazCom; included in FDA pharmaceutical database
Europe: Included under REACH as an existing chemical; comply with CLP guidelines for labeling
Canada: Subject to WHMIS regulations as a hazardous chemical
Other Regulations: Comply with relevant laws regarding pharmaceutical precursor materials; local workplace safety and environmental protection standards apply
