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Chemical Name: 7-Dehydrocholesterol
Synonyms: Provitamin D3, 7-DHC
CAS Number: 434-16-2
Available Forms: Solid, crystalline powder
Recommended Use: Laboratory chemical, vitamin D synthesis research
Supplier Details: Manufacturer and distributor contact information should be accessed directly from purchase label
Emergency Telephone: Provided by supplier—refer to the packaging for specific number
GHS Classification: Not classified as a hazardous substance by GHS standards for pure chemicals
Signal Word: None assigned under GHS guidelines
Pictogram: No pictogram required
Hazard Statements: May cause eye, skin, or respiratory irritation if exposed in sufficient quantities; possible impact from excessive ingestion
Risk Assessment: Handling generates dust that can cause respiratory irritation; skin and eye contact need to be limited through appropriate precautions
Precautionary Statements: Prevent ingestion, inhalation, and direct contact with eyes and skin; maintain use in well-ventilated settings
Substance: 7-Dehydrocholesterol
Molecular Formula: C27H44O
Molecular Weight: 384.6 g/mol
Purity: Typically ≥98% as provided by suppliers
Other Ingredients: No additional constituents present in concentrations that would classify as hazardous
General Advice: Move exposed individuals away from source of exposure and into fresh air
Inhalation: Move to fresh air; seek medical attention if symptoms develop or persist
Skin Contact: Wash affected area with plenty of water and mild soap; remove contaminated clothing
Eye Contact: Rinse with lukewarm water for at least 15 minutes; keep eyelids open and move eyes in all directions
Ingestion: Rinse mouth with water; never give anything by mouth to an unconscious person; contact medical personnel if unwell
Most Important Symptoms: Irritation of eyes, skin, and respiratory tract possible, but no long-term effects reported for typical laboratory exposures
Medical Attention: Seek medical care in the event of persistent adverse effects or accidental large-scale exposure
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, foam, or water spray as appropriate for surrounding materials
Specific Hazards: Combustible, may emit toxic fumes such as carbon monoxide and carbon dioxide during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Special Procedures: Approach fire from upwind direction and use water spray to cool containers exposed to fire
Explosion Risk: Not known to present significant explosion risk under normal laboratory conditions
Personal Precautions: Wear suitable protective clothing, including gloves, lab coat, goggles, and mask to avoid inhalation of dust
Environmental Precautions: Prevent undiluted product or large quantities from entering drains, sewers, or waterways
Methods for Containment and Clean Up: Avoid creating dust; sweep up material with minimal dust generation, collect in a clearly labeled closed container for proper disposal; ventilate area extensively
Decontamination: Clean spill area thoroughly after collection, ensuring no residue remains; dispose of waste in accordance with local regulations
Safe Handling: Work in a well-ventilated environment or chemical fume hood; avoid inhalation, ingestion, or direct contact with substance
Storage Conditions: Store tightly sealed in a cool, dry place away from direct light, moisture, and incompatible substances such as oxidizing agents; ideal storage temperature kept below 20°C
Handling Precautions: Use appropriate containment to avoid spread of dust; do not eat, drink, or smoke where the chemical is used or stored
Specific End Uses: Limit use to trained personnel following standard laboratory protocols
Occupational Exposure Limits: No specific exposure limits established; use good laboratory practice to minimize contact
Engineering Controls: Use chemical fume hood or adequate local exhaust ventilation
Eye/Face Protection: Safety goggles with side shields or face shield recommended
Skin Protection: Chemical-resistant gloves and a lab coat
Respiratory Protection: Dust mask or respirator (approved for particulate matter) where dust generation occurs
Hygiene Measures: Wash hands and exposed skin after handling; avoid touch to eyes and skin intentionally
Appearance: White or off-white crystalline solid
Odor: Mild, characteristic
Odor Threshold: Not established
pH: Not applicable (insoluble in water)
Melting Point: Around 150–156°C
Boiling Point: Not determined
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Low
Vapor Pressure: Extremely low at room temperature
Solubility: Insoluble in water, soluble in many organic solvents (ethanol, chloroform, diethyl ether)
Partition Coefficient: log Kow approximately 8.8 (highly lipophilic)
Vapor Density: Not applicable
Decomposition Temperature: Not fully established, but decomposes with heat
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to excessive heat, light, air, or moisture
Incompatible Materials: Strong oxidizing agents such as peroxides, acids; avoid reactive metals
Hazardous Decomposition Products: On combustion, releases toxic gases such as carbon monoxide and carbon dioxide
Polymerization: Not known to occur
Reactivity: No hazardous reactivity under normal laboratory conditions
Acute Toxicity: Data limited; considered low based on structural analogues and routine laboratory handling experience
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Effects from Short-Term Exposure: Dust may cause mild irritation to respiratory system, eyes, or skin; swallowing can induce mild gastrointestinal discomfort
Effects from Prolonged Exposure: Prolonged or repeated exposure by inhalation or contact not shown to cause significant adverse health effects, but should be avoided as a general safety practice
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Mutagenicity: No well-documented evidence to support mutagenic risk
Reproductive Toxicity: No known reproductive hazards
Sensitization: No data indicating potential for allergic response
Ecotoxicity: No substantial ecological risk identified for typical laboratory use; not classified as hazardous to aquatic environments
Persistence and Degradability: 7-Dehydrocholesterol is expected to undergo slow degradation in the environment, typical of many sterols
Bioaccumulation Potential: Data suggest that it could accumulate in organisms owing to high log Kow
Mobility in Soil: Likely to adsorb strongly to soil particles due to lipophilicity
Other Adverse Effects: None known under proper handling and disposal practices
Waste Treatment Methods: Collect material using clean, dry methods; avoid generation of dust
Waste Disposal: Dispose through licensed hazardous chemical waste contractors—refer to local, regional, and national regulations
Container Disposal: Empty containers should be triple rinsed and punctured before disposal, following institutional protocols
Environmental Considerations: Avoid direct release to environment or water bodies; never flush to drain
UN Number: Not classified under current UN transport codes
Proper Shipping Name: Not regulated for transport in most jurisdictions
Hazard Class: Not assigned
Packing Group: Not applicable
Special Precautions: Protect from physical damage and exposure to sunlight during transport
Environmental Hazards: Does not meet criteria for environmentally hazardous substances
Transport in Bulk: Not intended for bulk transport
Regulatory Status: 7-Dehydrocholesterol is not subject to specific national or regional chemical control laws
OSHA: Not specifically regulated; general laboratory safety standards apply
TSCA: Listed in the United States Toxic Substances Control Act Inventory
REACH: Exempt or not listed due to use as a research/laboratory chemical
Other Regulations: Not classified as hazardous under EU CLP, US SARA Title III, or Canadian WHMIS
Label Elements: General chemical label, hazard and precaution sentences reflecting irritation potential, recommended storage, and handling instructions
