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Chemical Name: 7-Amino-3-vinylcephalosporanic acid
Synonyms: 7-ACA-3-Vinyl, 7-ACA derivative
Chemical Formula: C13H14N4O4S
CAS Number: 52514-52-4
Recommended Use: Intermediate for cephalosporin antibiotics
Supplier: Details available on request
Contact Information: Emergency number, supplier contact, and local poison center provided on shipment paperwork
GHS Classification: Irritant, Sensitizer
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, may cause respiratory irritation, possible eye damage, can cause irritation to mucous membranes
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use only outdoors or in well-ventilated area, wear protective gloves and eye protection, avoid contact with skin and eyes, do not eat, drink, or smoke when using product
Chemical: 7-Amino-3-vinylcephalosporanic acid
Concentration: 98% minimum purity
Impurities: Residual solvents and related cephalosporin derivatives, typically below 2% combined
Other Components: None considered hazardous in concentrations present
Molecular Structure: Beta-lactam cephalosporin ring with vinyl and amino functional groups
Contact with Eyes: Rinse gently with water for at least 15 minutes holding eyelids open, remove contact lenses, seek medical attention if irritation persists
Contact with Skin: Wash thoroughly with water and soap, remove contaminated clothing, seek medical attention if symptoms continue
Inhalation: Move person to fresh air, keep at rest, obtain medical attention for breathing difficulties
Ingestion: Rinse mouth thoroughly, drink water if conscious, do not induce vomiting, get medical help immediately
Most Important Symptoms: Allergic reaction, respiratory tract irritation, eye redness, skin rash
Suitable Extinguishing Media: Water spray, CO2, dry chemical, foam
Unsuitable Media: Direct water jet can spread product
Fire Hazards: Produces toxic fumes including nitrogen oxides, sulfur oxides, carbon oxides on decomposition
Protective Equipment: Full protective gear, self-contained breathing apparatus
Special Precautions: Evacuate area, stay upwind, prevent runoff into water sources
Personal Precautions: Wear respiratory protection, chemical-resistant gloves, safety goggles, avoid dust formation
Environmental Precautions: Prevent entry into drains, waterways, and soil
Containment: Avoid generating dust, sweep up carefully, place into suitable containers for disposal
Cleanup Methods: Use damp cloths or HEPA filter vacuuming for residue, ventilate area thoroughly, dispose of waste via licensed contractor
Safe Handling: Use local exhaust ventilation, minimize dust and aerosol formation, avoid skin and eye contact, handle in closed system or with containment
Storage Conditions: Keep tightly sealed in original containers, store at 2-8°C, protect from light and moisture
Incompatible Materials: Strong acids, alkalies, oxidizing agents, certain metal ions
Special Precautions: Label all containers, keep away from food and drink, restrict access to trained personnel
Engineering Controls: Chemical fume hood, local exhaust extraction, safety shower and eyewash nearby
Respiratory Protection: Approved dust mask or respirator (N95 or higher)
Skin Protection: Disposable nitrile gloves, lab coat, long sleeves
Eye Protection: Tight-fitting safety goggles or face shield
Environmental Controls: Prevent release to environment, use containment where practical
Appearance: White to pale yellow powder
Odor: Odorless to faintly chemical
Melting Point: Decomposes before melting over 200°C
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, soluble in polar organic solvents
pH: Neutral to slightly acidic (5.5–7.0) in aqueous suspension
Vapor Pressure: Not measurable at ambient conditions
Partition Coefficient (log Kow): Data not available
Flash Point: Not flammable under standard conditions
Auto-ignition Temp: Data not available
Chemical Stability: Stable under recommended storage conditions, sensitive to hydrolysis
Conditions to Avoid: Excessive heat, humidity, exposure to air and light
Incompatible Materials: Strong oxidizers, acids, bases, metals like iron and copper
Hazardous Decomposition Products: May release CO2, CO, NOx, SOx on thermal decomposition
Hazardous Reactions: Polymerization not known to occur, cephalosporin ring may react with strong nucleophiles
Acute Toxicity: Data limited, related compounds show low oral toxicity in rodents (LD50 > 2000 mg/kg)
Skin Corrosion/Irritation: Possible skin irritant, may trigger allergic dermatitis
Eye Damage/Irritation: May cause redness, pain, conjunctival irritation
Respiratory Sensitization: Can cause asthma-like symptoms in susceptible individuals
Carcinogenicity: No data for compound, not listed as carcinogen by IARC, NTP or OSHA
Mutagenicity: Not tested, related beta-lactams negative or weakly positive in standard tests
Other Chronic Effects: Risk of allergy and sensitization in repeated or occupational exposure
Ecotoxicity: Aquatic toxicity not fully characterized, beta-lactams can affect aquatic microbiota
Persistence and Degradability: Degrades slowly under environmental conditions, susceptible to hydrolysis
Bioaccumulation Potential: Low, based on structure and physicochemical properties
Mobility in Soil: Likely low-moderate due to water solubility and ionizable groups
Other Hazards: Potential for antibiotic resistance development if released in significant quantities to environment
Waste Disposal Method: Treat as hazardous chemical waste, incinerate or use licensed chemical disposal facility
Container Disposal: Triple rinse containers, puncture, dispose according to local regulations
Special Precautions: Avoid release to environment, do not flush to sewer, consult local authorities for exact requirements
Recycling/Reuse: Not recommended, product is typically single-use
UN Number: Not classified under major transport regulations
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Precautions for Transport: Store in well-sealed packaging, temperature-controlled, secondary containment recommended to prevent loss during accident
Special Requirements: Avoid extreme temperatures and mechanical shocks during transit, keep separate from incompatible materials
Labeling: GHS-compliant labeling with hazard pictograms and warning statements
TSCA Status: Not listed as of current database update
REACH Status: Not registered, use covered under research or intermediate exemption
OSHA Hazard Category: Irritant, sensitizer
SARA Title III: Not reportable in routine commercial quantities
Other International Regulations: Subject to local chemical inventory and health and safety legislation
User Requirements: Handle only with appropriate training, documentation kept for audits and traceability, report spills to authorities as required by law
