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Material Safety Data Sheet – 7-Amino-3-Desacetoxy-3-Cephem-4-Carboxylic Acid

Identification

Product Name: 7-Amino-3-Desacetoxy-3-Cephem-4-Carboxylic Acid
Chemical Formula: C8H9N3O3S
Synonyms: 7-ADCA, 7-Amino-3-desacetoxycephalosporanic acid
CAS Number: 3736-08-1
Intended Use: Intermediate for antibiotics production
Supplier: Manufacturer contact details displayed on final packaging
Emergency Contact: Refer to supplier emergency contact system or local poison control authority

Hazard Identification

Hazard Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Respiratory sensitization (Category 1)
GHS Label Elements: Exclamation mark, Health hazard pictogram
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation, may cause allergy or asthma symptoms if inhaled, may cause respiratory irritation
Precautionary Statements: Avoid contact with skin, eyes, and clothing, use only with adequate ventilation, keep container tightly closed, wash hands thoroughly after handling
Routes of Exposure: Inhalation, skin and eye contact

Composition / Information on Ingredients

Chemical: 7-Amino-3-Desacetoxy-3-Cephem-4-Carboxylic Acid
Concentration: ≥ 97% by weight
Other Components: Inert processing residues, ≤ 1%
Impurities: Minimal levels of organic solvent residues (from synthesis)

First Aid Measures

Inhalation: Move person to fresh air, provide oxygen if breathing is difficult, seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, consult physician if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if easy to do, continue rinsing and seek medical advice
Ingestion: Rinse mouth, do not induce vomiting, consult medical advice immediately
Important Symptoms: Cough, redness, rash, respiratory discomfort, possible allergic reactions

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Specific Hazards: May emit hazardous nitrogen oxides, sulfur oxides, carbon oxides when burned
Protective Equipment and Precautions: Use full protective gear, self-contained breathing apparatus, avoid breathing dust or fumes
Advice for Firefighters: Stay upwind, move containers from fire area if it can be done safely, avoid contamination of water sources with run-off

Accidental Release Measures

Personal Precautions: Evacuate area, avoid dust generation, use personal protective equipment as indicated
Environmental Precautions: Prevent spillage from entering drains, surface or groundwater, report releases following regulations
Cleanup Procedures: Collect spillage using damp cloth or vacuum equipped with HEPA filter, transfer to labeled waste containers, ventilate spill area

Handling and Storage

Safe Handling: Handle in a chemical fume hood, avoid contact with skin, eyes, and clothing, do not eat, drink, or smoke when using this product
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated place, protect from light and moisture, segregate from incompatible substances
Incompatibilities: Strong oxidizing agents, acids, strong bases, reducing agents
Special Precautions: Ensure containers remain properly labeled, avoid breathing dust, use only with adequate ventilation

Exposure Controls and Personal Protection

Occupational Exposure Limit: No established value (observe good laboratory hygiene practices)
Engineering Controls: Use chemical fume hood, eye wash stations and emergency showers available
Personal Protection: Wear appropriate laboratory gloves (nitrile recommended), chemical splash goggles, lab coat, respiratory protection if dust likely
Hygiene Measures: Wash hands and face after handling, remove contaminated clothing and launder before reuse, do not touch face during work

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: Decomposes above 180°C
Solubility: Sparingly soluble in water, slightly soluble in organic solvents (methanol, ethanol)
pH: Slightly acidic in aqueous suspension (approx. 5.2)
Boiling Point: Data unavailable (decomposes before boiling)
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable
Density: Approx. 1.5 g/cm³
Partition Coefficient: Not determined

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Decomposition Products: Nitrogen oxides, sulfur oxides, carbon oxides
Conditions to Avoid: Exposure to heat, moisture, light
Reactivity: May react with strong oxidizing agents
Polymerization: Does not occur under normal laboratory conditions

Toxicological Information

Acute Toxicity: Inhalation of dust may cause respiratory tract irritation, single dose oral toxicity data not thoroughly documented
Chronic Effects: Prolonged or repeated exposure may cause sensitization, possible allergic reactions, skin or respiratory effects
Carcinogenicity: No data available on carcinogenic effects
Reproductive Toxicity: No conclusive studies found
Symptoms: Skin redness, itching, swelling, coughing, wheezing in sensitive individuals
Target Organs: Skin, eyes, respiratory system

Ecological Information

Ecotoxicity: Expected to be low toxicity to aquatic organisms but direct contamination can have adverse effects
Persistence and Degradability: Not easily biodegradable, persistence in water or soil possible
Bioaccumulative Potential: Bioaccumulation not anticipated based on structural properties
Mobility in Soil: Likely low, compound not highly water soluble, binds to soil particulates
Other Adverse Effects: Avoid release into environment, follow local environmental regulations

Disposal Considerations

Disposal Methods: Collect waste in sealed containers, label as chemical waste, send for incineration or managed chemical waste processing
Contaminated Packaging: Dispose of as unused product, rinse containers thoroughly before recycling when allowed
Special Precautions: Follow governmental and environmental disposal guidelines, avoid direct release to drains or surface waters

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not assigned
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not assigned
Special Transport Precautions: Keep containers closed, avoid jostling, shield from mechanical and thermal stress during transit

Regulatory Information

Inventory Status: Listed or exempt on main chemical inventories (TSCA, EINECS, DSL)
Hazard Labeling: Required according to GHS and local regulations
Workplace Control: OSHA Laboratory Standard applies if used in workplace labs
Restrictions: Subject to use for research, manufacturing, or specified processes only
Other Information: Observe workplace safety regulations, report any significant spillage or exposure as mandated by law