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Product Name: 7-Amino-3-Chloro-3-Cephem-4-Carboxylic Acid Ethyl Ester
Synonyms: ACC; ACC-ethyl ester
Chemical Formula: C10H11ClN2O3S
Molecular Weight: 274.73 g/mol
Chemical Family: Cephem antibiotics intermediate
Intended Use: Research, pharmaceutical development
Supplier Contact Info: Address, telephone, email provided by manufacturer
Emergency Contact: Local and national emergency numbers, CHEMTREC when shipping in the US
GHS Classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 2, Eye Damage Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Wash skin thoroughly after handling, avoid contact with eyes and skin, do not eat or drink around the material, use in well-ventilated area
Overexposure Symptoms: Redness, itching, eye watering, upset stomach, headache
Aggravated Medical Conditions: Asthma, skin disorders, chronic respiratory diseases can increase risk of side effects
Chemical Identity: 7-Amino-3-Chloro-3-Cephem-4-Carboxylic Acid Ethyl Ester
CAS Number: 58706-81-5
Purity: More than 98%
Impurities: Trace by-products (usually less than 2%) from synthesis
Stabilizers/Additives: None in standard material
Formulation: Pure substance, used as solid or in solution depending on application
General: Remove from exposure, seek fresh air or well-ventilated place, check for discomfort
Inhalation: Move person to fresh air, loosen tight clothing, give oxygen if breathing is difficult, seek immediate medical attention if symptoms persist
Skin Contact: Remove contaminated clothes, wash skin with soap and plenty of water for at least 15 minutes, monitor for irritation, seek medical attention if rash or discomfort occurs
Eye Contact: Flush with plenty of lukewarm water for 20 minutes, hold eyelids apart, remove contact lenses, do not rub eyes, seek medical advice immediately
Ingestion: Rinse mouth, give water if person is conscious, never induce vomiting unless instructed by medical personnel, seek medical attention immediately
Information for Doctors: Treat symptomatically, monitor vitals, support respiratory and cardiovascular functions
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: During fire, toxic and irritating gases (hydrogen chloride, nitrogen oxides, sulfur oxides, carbon monoxide) can form
Protective Equipment: Full protective suit, self-contained breathing apparatus, gloves, boots
Procedures: Move containers away if safe to do so, prevent run-off into drains and water sources, control fire with minimum personnel
Fire/Explosion Risk: Powder or dust can form explosive mixtures with air, avoid dust accumulation
Decomposition Products: Fumes of HCl, nitrogen oxides, and sulfur dioxide
Personal Precautions: Avoid breathing dust, wear eye protection, use chemical-resistant gloves and protective clothing, ventilate area
Environmental Precautions: Prevent release into drains, soil, or any natural water bodies, alert local authorities if large spill occurs
Cleanup Methods: Sweep up with minimal dust generation, use vacuum with HEPA filter for fine particles, transfer to labeled container for disposal, wash area with mild detergent and water
Decontamination: Wipe surfaces, dispose cleaning materials as hazardous waste
Special Instructions: Use only tools and equipment that prevent spark formation
Handling: Use in fume hood or well-ventilated area, avoid dust generation, handle with proper PPE (gloves, goggles, lab coat), keep away from incompatible materials like strong oxidizers and acids
Hygiene Practices: Wash hands before eating or drinking, do not smoke or eat in work area, keep chemical away from open flames or heat sources
Storage Conditions: Store in tightly closed original container, keep in cool, dry, well-ventilated area, avoid direct sunlight, protect from moisture, refrigerate at 2–8°C for best stability
Incompatibility: Strong oxidizing agents, acids, bases, reducing agents, moisture
Container Materials: Use glass, HDPE, or compatible chemical-resistant plastic containers
Respiratory Protection: Use NIOSH-approved respirators for dust exposure, preferably P100 or FFP3 masks
Hand Protection: Wear chemical-resistant nitrile, neoprene, or latex gloves, change gloves when contaminated
Eye Protection: Safety goggles with side shields, face shield during bulk handling
Skin Protection: Wear lab coat, apron, full-sleeve shirt and pants, closed footwear
Engineering Controls: Use exhaust ventilation and fume hood, implement dust control measures, install eyewash station and safety shower nearby
Exposure Limits: Not established specifically for this compound, but minimize exposure according to best practices
Monitoring: Periodic air sampling in production or research areas advised
Appearance: White to off-white crystalline powder
Odor: Nearly odorless or faint chemical scent
pH: 3 to 5 in 1% aqueous solution
Melting Point: 158–164°C (destructive decomposition possible)
Boiling Point: Not measurable (decomposes before boiling)
Solubility: Slightly soluble in water; readily dissolves in certain organic solvents like DMSO, methanol
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.5 g/cm³
Partition Coefficient (Log Kow): Not available
Flash Point: Not available; handle as non-flammable solid
Evaporation Rate: Not volatile
Autoignition Temperature: Not determined
Upper/Lower Flammability Limit: Not applicable
Chemical Stability: Stable at recommended storage conditions, degrades with prolonged exposure to light, air, heat, or moisture
Reactivity: No hazardous reactivity under normal laboratory conditions
Decomposition: Releases toxic or irritating fumes under fire or extreme heat
Polymerization: No hazardous polymerization expected
Incompatible Materials: Strong oxidizers, acids, bases, reducing agents, moisture
Other Hazards: May be sensitive to light and humidity, potential for dust-related respiratory irritation
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) greater than 2000 mg/kg; dust inhalation can cause irritation
Skin Corrosion/Irritation: Causes redness, itching, possible rash
Eye Damage/Irritation: Produces pain, watering, redness
Chronic Effects: Prolonged/repeated exposure may cause sensitization or allergic reactions in some individuals
Carcinogenicity: Components not listed by IARC, NTP, OSHA as carcinogenic
Reproductive Toxicity: Insufficient data on animal or human reproductive risk
Mutagenicity: No genotoxic effects recorded for this substance at workplace exposure levels
Target Organs: Eyes, skin, mucous membranes, respiratory tract
Medical Conditions Exacerbated: Asthma, dermatitis, allergy increases vulnerability
Ecotoxicity: No detailed ecotoxicological data available for this compound; related beta-lactam compounds can be hazardous to aquatic organisms at high concentrations
Aquatic Toxicity: Estimated LC50 for fish and invertebrates >100 mg/L (low acute risk for accidental release in small amounts)
Mobility in Soil: Possible slow mobility, low volatility, some risk of leaching in moist environments
Persistence/Degradability: Not rapidly degradable in natural environments; breaks down slowly via microbial activity
Bioaccumulation Potential: Low; chemical structure and solubility suggest minimum risk of biomagnification
Other Effects: Potential for antibiotic resistance genes to enter environment if not properly handled
Waste Treatment: Treat as hazardous laboratory waste, contain in appropriate drum or container
Disposal Methods: Incinerate in licensed facility, follow all federal, state, and local environmental regulations, avoid disposing into drains or general waste streams
Packaging: Destroy or clean containers before recycling, label as hazardous waste
Regulatory Waste Codes: Check local and regional requirements for pharmaceutical intermediate residues
Contaminated Materials: Dispose gloves, wipes, and safety gear as chemically contaminated waste
UN Number: Not classified
DOT/ADR/RID/IMDG/IATA: Not regulated for transport, handle as limited quantity chemical
Packing Group: None specified
Proper Shipping Name: Non-hazardous for most routes under 500g bottle sizes, check current regulations for bulk shipments
Special Transport Precautions: Avoid vibration, drops, temperature extremes, secure packaging to avoid leaks
TSCA Status: Not listed for commercial application under US TSCA
REACH/EC: Registered as research use intermediate only, subject to control in Europe
SARA Title III: Not subject to SARA Title III reporting
OSHA Hazard Chemicals: Classified as hazardous under OSHA Hazard Communication Standard
California Proposition 65: Not listed
Other National Regulations: Refer to country-specific chemical inventories, applicable worker protection and environmental frameworks
Labeling Requirements: GHS-compliant labels showing hazard classification, signal words, hazard pictogram, and supplier details
