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Product Name: 7-ADCA (7-Amino-3-Deacetoxycephalosporanic Acid)
Synonyms: 7-ADCA
CAS Number: 33605-67-9
Molecular Formula: C11H12N2O4S
Molecular Weight: 268.29 g/mol
Recommended Uses: Chemical intermediate for cephalosporin antibiotics
Supplier Details: Company address, phone, and emergency contact information listed directly on shipping containers and datasheets
Classification: May cause allergic reactions, irritation to skin and eyes, respiratory tract sensitivity
Label Elements: Hazard pictograms as standard for irritants and health hazards
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation; respiratory sensitizer; may cause allergy or asthma symptoms on inhalation
Precautionary Statements: Avoid breathing dust; use personal protective equipment; handle in a well-ventilated area; wash exposed skin thoroughly after handling; keep container tightly closed
Other Dangers: Prolonged exposure without adequate protection can increase risk of allergic response and may trigger severe reactions in sensitive individuals
Chemical Name: 7-Amino-3-deacetoxycephalosporanic acid
CAS Number: 33605-67-9
Content: >97% purity
Impurities: Related cephalosporin derivatives in trace amounts
Inhalation: Move person to fresh air; administer oxygen if breathing is difficult; seek medical advice immediately for any persistent discomfort or respiratory symptoms
Skin Contact: Remove any contaminated clothing; wash area thoroughly with soap and water; seek medical advice if irritation or allergic response develops
Eye Contact: Rinse cautiously with water for at least 15 minutes, keeping eyelids open; remove contact lenses if present and easy to do; get medical attention
Ingestion: Rinse mouth with water; do not induce vomiting; seek prompt medical attention; provide symptomatic and supportive care
Note to Physician: Monitor for allergic symptoms and treat as anaphylaxis if severe reaction occurs; consider corticosteroids and antihistamine therapy if indicated
Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, foam
Unsuitable Extinguishing Media: Do not use high-volume water jet in confined spills
Specific Hazards: Combustion may release nitrogen oxides, sulfur oxides, carbon monoxide, and other toxic fumes
Firefighter Protection: Use self-contained breathing apparatus and protective clothing in hazardous conditions; approach from upwind to avoid exposure to combustion gases
Explosion Risk: Not classified as explosive, dust in high concentrations may form explosive mixtures with air
Personal Precautions: Avoid contact with skin and eyes; wear personal protective equipment including gloves, goggles, and particulate respirator
Emergency Procedures: Restrict access to contaminated area; ventilate location; evacuate any unnecessary personnel
Environmental Precautions: Prevent spill from entering drains, surface water, or soil; contain any runoff with inert material such as earth or sand
Cleaning Methods: Collect solid material by vacuum or careful sweeping; clean contaminated area with damp cloth and dispose of all cleaning materials as hazardous waste; avoid creating dusty conditions
Handling: Avoid contact with skin, eyes, and clothing; do not inhale dust; handle in well-ventilated area or fume hood when possible; use dedicated equipment to limit potential for cross-contamination
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in the work area; remove contaminated clothing and wash before reuse
Storage: Store in tightly sealed containers, protected from light, moisture, and incompatible materials; keep at 2–8°C in dry conditions; segregate from strong acids, bases, and oxidizers
Packaging Materials: Use chemically compatible, sealed, and labeled packaging
Exposure Guidelines: No established occupational exposure limit; minimize exposure to dust
Engineering Controls: Use local exhaust ventilation, process enclosures, or chemical fume hood for dust control
Personal Protective Equipment: Nitrile gloves, lab coat, chemical safety goggles, disposable dust mask or N95 respirator
Environmental Controls: Prevent material from escaping into environment by using proper waste and air filtration systems
Work Practices: Use nonbreakable containers, minimize dust generation, keep containers closed except during transfer, label all working solutions clearly
Physical State: Solid, crystalline powder
Color: White to off-white
Odor: Odorless
pH: Neutral to slightly acidic (in water)
Melting Point: Approximately 194°C (decomposition)
Solubility: Slightly soluble in water; soluble in dilute acids
Boiling Point: Not applicable (decomposes on melting)
Vapor Pressure: Negligible
Partition Coefficient (log Kow): Not determined
Flash Point: Not flammable
Auto-Ignition Temperature: Not self-igniting
Evaporation Rate: Not applicable
Density: Similar to other cephalosporin intermediates
Chemical Stability: Stable under recommended storage and handling conditions; moisture and light sensitive
Possibility of Hazardous Reactions: May react with strong oxidizing agents, acids, and bases
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Conditions to Avoid: High humidity, elevated temperatures, exposure to light
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, and other toxic gases upon thermal decomposition
Acute Toxicity: Low acute toxicity based on available data; specific values may vary (oral LD50 in rats >2000 mg/kg)
Skin Contact: Causes irritation, can trigger allergic reactions with repeated exposure
Eye Contact: Irritating to eyes, may cause redness and tearing
Inhalation: Dust may cause respiratory irritation or asthma-like symptoms, especially in sensitized individuals
Skin Sensitization: Classified as a skin sensitizer
Chronic Toxicity: Repeated handling may result in increased risk of allergic dermatitis or respiratory sensitization
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Mutagenicity/Teratogenicity: No data indicating genotoxicity or developmental risks
Other Information: Medical surveillance may be advisable in workplaces with repeated use; avoid long-term contact
Ecotoxicity: Not expected to be highly toxic to aquatic organisms; data limited, but antibiotic intermediates often require containment to prevent resistance spread
Persistence and Degradability: Slow degradation in environment; risk of persistence depending on local conditions
Bioaccumulation Potential: Low bioaccumulation risk based on chemical structure
Mobility in Soil: Moderate; can move with surface water or leach through soil in larger spills
Other Effects: Antibiotic-related compounds can affect microbial populations if discharged to environment; proper containment and wastewater management should be in place
Waste Disposal Methods: Treat as hazardous chemical waste; collect in properly labeled containers for disposal; incineration at licensed facility recommended
Contaminated Packaging: Rinse with water and dispose as hazardous waste or incinerate empty containers
Disposal Precautions: Follow local, regional, national, and international regulations for disposal; do not allow substance to enter drains, surface water, or soil
Special Considerations: Document all disposal procedures; maintain records as required for audit and regulatory compliance
UN Number: Not classified as dangerous good for transport under most regional/national transport regulations
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Labels Required: No transport-specific warning labels required; safety labeling required on containers
Special Transport Precautions: Protect from rough handling, moisture, and direct sunlight during shipment; keep container closed and upright
Inventory Status: Listed or exempted on major chemical inventories (e.g., US TSCA, EU REACH, China IECSC, Japan ENCS)
OSHA Status: Not specifically regulated as hazardous by OSHA, but falls under general chemical hygiene requirement
WHMIS Classification: May be regulated as irritant and sensitizer under Canadian regulations
Other Regulations: Complies with international standards for pharmaceutical intermediate handling; workplace exposure should follow occupational safety rules for allergens and chemical intermediates
Labeling Requirements: GHS hazard pictograms and statements required, as well as workplace hazard communication
Customs and Import: Importers and exporters must ensure declaration in accordance with chemical and pharmaceutical controls in relevant jurisdictions
Chemical Safety Assessment: Safety assessment and risk management measures documented for industrial use
