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Product name: 7-Aminocephalosporanic Acid
Synonyms: 7-ACA
CAS No.: 37517-28-5
EC No.: 253-309-1
Molecular formula: C10H12N2O5S
Molecular weight: 272.28 g/mol
Recommended use: Antibiotic intermediate, pharmaceutical synthesis
Manufacturer contact: Emergency phone numbers, company address, and responsible person for safety issues should be present on the original MSDS document
Emergency telephone: Refer to the company-specific details
GHS Classification: Eye irritation (Category 2A), Skin sensitization (Category 1), Respiratory sensitization (Category 1)
Signal word: Warning
Hazard statements: Causes serious eye irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled
Pictograms: Exclamation mark, Health hazard
Precautionary statements: Avoid breathing dust, wear protective gloves and eye protection, wash hands thoroughly after handling, use in a well-ventilated area, if in eyes rinse cautiously with water
Potential health effects: Sensitization through inhalation and skin contact, possible exacerbation of asthma, known cross-sensitivity with penicillins and other beta-lactam antibiotics
Label elements: Clearly marked for workplace hazards
Immediate hazards: Exposure can provoke allergic response and irritation
Chemical name: 7-Aminocephalosporanic Acid
Purity: >98%
Impurities: Residual solvents, related cephalosporin derivatives under accepted limits
Hazard components: No other hazardous ingredients according to GHS or OSHA standards
Formulation: Pure powder, no added excipients or preservatives
Ingredient category: Primary active ingredient
Inhalation: Move individual to fresh air, seek medical attention if symptoms appear, monitor for respiratory distress
Skin contact: Remove contaminated clothing, rinse skin thoroughly for at least 15 minutes, watch for irritation or allergic reaction, seek medical help if symptoms persist
Eye contact: Irrigate eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, seek immediate medical advice
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, seek medical attention, monitor for signs of allergic response
Notes to physician: Treat symptomatically, monitor for delayed allergic reaction or asthma symptoms
Self-protection for first responders: Wear gloves and mask, avoid direct contact with powder
Suitable extinguishing media: Water spray, dry chemical, carbon dioxide, foam
Special hazards: Thermal decomposition releases toxic vapors including sulfur oxides, nitrogen oxides, carbon oxides
Protective equipment: Firefighters should use self-contained breathing apparatus and protective clothing
Explosion hazards: Dust accumulation can create explosion risk in poorly ventilated or enclosed spaces
Precautions: Prevent runoff from fire control from entering drains, sewers, or waterways
Unusual fire or explosion hazards: Powder may become airborne and ignite, use caution with ventilation
Personal precautions: Wear suitable respiratory protection, gloves, and protective clothing, ventilate area, prevent generation of dust
Environmental precautions: Avoid discharge to environment or drains, prevent further leakage or spillage
Containment methods: Cover and collect spillage using damp cloth or absorbent, avoid dry sweeping
Cleanup methods: Collect and place in suitable, labeled container for disposal according to local regulations, wash spill area thoroughly after collection
Reporting: Inform appropriate environmental agency if larger spills occur or contamination of water systems is possible
Handling: Minimize dust generation and accumulation, use local exhaust ventilation, employ safe laboratory practices, avoid inhalation and contact with skin or eyes, keep containers tightly closed when not in use
Storage conditions: Store at 2-8°C (refrigerator temperature), avoid exposure to heat and moisture, store in original container, keep away from incompatible substances such as strong oxidizers or acids
Special requirements: Ensure storage area is secure, restrict access to trained personnel, label container clearly with hazard information
Safe handling advice: Do not eat, drink, or smoke while handling, practice good hygiene
Shelf life: Stable for at least 2 years under recommended storage conditions, monitor for signs of degradation
Occupational exposure limits: No established limit for 7-ACA, handle as a sensitizer
Engineering controls: Use fume hood or local exhaust, ensure eyewash stations and safety showers are accessible
Respiratory protection: Wear certified particulate respirator if dust exposure possible
Eye protection: Chemical safety goggles or face shield
Skin protection: Laboratory coat, gloves made from nitrile or other chemical-resistant material
Hygiene measures: Regular hand washing, avoid contact with skin and eyes, remove contaminated clothing before leaving work area
Monitoring methods: Regular cleaning of worksite, monitor for dust levels in the air
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor threshold: Not available
Melting point: 195°C - 198°C (decomposes)
Boiling point: Not applicable (decomposes before boiling)
Vapor pressure: Not applicable
Solubility: Slightly soluble in water, insoluble in organic solvents such as ether
Partition coefficient (log Kow): Not available
pH: 4.0 - 6.0 (1% aqueous solution at 25°C)
Flash point: Not applicable
Evaporation rate: Not available
Flammability (solid, gas): May be combustible as fine dust
Autoignition temperature: Not determined
Decomposition temperature: Above 195°C
Viscosity: Not applicable
Explosive properties: Dust can form explosive mixtures with air
Chemical stability: Stable under specified conditions (cool, dry, well-sealed)
Possibility of hazardous reactions: Reacts with strong oxidizers, acids
Conditions to avoid: Exposure to heat, moisture, direct sunlight
Incompatible materials: Oxidizing agents, acids, strong bases
Hazardous decomposition products: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Does not occur under normal storage or handling conditions
Information on likely routes of exposure: Inhalation, skin contact, eye contact, ingestion
Acute toxicity: Oral LD50 (rat): >2000 mg/kg (low toxicity)
Skin corrosion/irritation: May cause mild to moderate irritation
Serious eye damage/irritation: Severe irritation possible
Respiratory sensitization: Can provoke asthmatic symptoms or allergic response through inhalation
Skin sensitization: Sensitizer through skin contact
Carcinogenicity: No components listed as carcinogen by IARC, NTP, OSHA
Mutagenicity: No conclusive data on mutagenic effects
Reproductive toxicity: Data not sufficient to assess risk
Symptoms: Rash, redness, swelling, shortness of breath, exaggerated for individuals with beta-lactam allergy
Chronic effects: Prolonged or repeated exposure may worsen allergy, asthma-like symptoms
Eco-toxicity: Harmful in high concentrations to aquatic life, chronic effects not well established
Persistence and degradability: Not rapidly biodegradable under standard conditions
Bioaccumulation potential: Not expected to bioaccumulate
Mobility in soil: Low mobility, binds to soil particles
Other adverse effects: No evidence of significant long-term environmental hazard outside localized spills
Precaution: Prevent discharges into water bodies, soil, and sewers to reduce ecological impact
Waste disposal methods: Incinerate by licensed chemical incineration facility, follow national and local regulations
Unused product: Dispose as hazardous chemical waste
Contaminated packaging: Dispose as hazardous waste, fully empty container before disposal, remove or deface labeling before discarding
Prohibited disposal methods: Do not dump into sewers, waterways, or open environment
Special considerations: Consult environmental authorities to ensure compliance
UN number: Not regulated as a dangerous good
Proper shipping name: Not classified as hazardous for transport by ADR, IMDG, IATA
Transport hazard class: None
Packing group: Not assigned
Special precautions for transport: Keep away from foodstuffs, avoid heat and moisture, pack securely to prevent breakage or spills
Environmental hazards: Not a marine pollutant
Bulk transport: Avoid dust generation in bulk handling
OSHA: Not regulated as a hazardous substance in the workplace under OSHA standards
TSCA (USA): Not listed
REACH (EU): Substance registered, use and handling subject to compliance
California Proposition 65: Does not contain chemicals known to cause cancer or reproductive harm
WHMIS (Canada): Pharmaceutical/Research exempt, but treat as sensitizer
Other regulations: Observe all applicable international, national, and local laws and regulations regarding chemical safety
Label requirements: Mark containers with physical and health hazard warnings
