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Product Name: 5-Hydroxy-L-Tryptophan
Chemical Formula: C11H12N2O3
Synonyms: 5-HTP, Oxitriptan, Grifonin
CAS Number: 56-69-9
Recommended Use: Laboratory chemicals, dietary supplement manufacturing
Supplier Details: Contact details of manufacturer or distributor, including emergency contact number and address, for direct communication in case an immediate concern arises about safety or exposure.
GHS Classification: Not classified as hazardous under GHS criteria
Potential Health Hazards: May cause mild irritation to eyes, skin, or respiratory system upon contact or inhalation; accidental ingestion can upset the stomach in large quantities; repeated overexposure could lead to cumulative nervous system impact.
Environmental Hazards: Not identified as highly toxic to aquatic environments, but large spills can disrupt local water biota.
Label Elements: None required by GHS, but precautionary and exposure guidance is still advisable.
Chemical Identity: 5-Hydroxy-L-Tryptophan
Purity: ≥ 98% (by HPLC or supplier's certificate of analysis)
Impurities: Minor organic impurities less than 2% by total weight, can include minor tryptophan derivatives
Additives: No additives provided under standard laboratory-grade product.
Inhalation: Remove individual to fresh air; monitor breathing; provide oxygen if breathing shows difficulty.
Skin Contact: Wash skin thoroughly with soap and water; remove contaminated clothing; monitor for irritation.
Eye Contact: Rinse eyes with water for at least 15 minutes; keep eyelids apart and seek medical attention if irritation continues.
Ingestion: Rinse mouth; do not induce vomiting without medical consultation; monitor for nausea or distress; seek medical help if significant quantities consumed.
Medical Attention: Present product label or safety data to health professionals for reference.
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam fire extinguishers.
Specific Hazards: Combustion may release oxides of carbon, nitrogen oxides, and other unidentified organic compounds.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear.
Firefighting Procedures: Avoid inhaling combustion gases; use water to cool containers; prevent contaminated water runoff from entering drains.
Personal Precautions: Use gloves, goggles, mask, and protective clothing to prevent contact with spill.
Environmental Precautions: Prevent material from entering surface water, soil, and sewers.
Cleanup Methods: Collect spillage with inert absorbent (sand, vermiculite); transfer to suitable labeled waste container; wash surface with water to remove residues.
Handling: Keep container tightly closed; use in well-ventilated area; avoid dust formation and direct contact with eyes, skin, and clothing; do not eat or drink while handling.
Storage: Store in cool, dry place away from incompatible materials such as strong oxidizers; protect from direct sunlight and moisture; maintain temperature between 2–8°C (refrigerated preferable); secure against unauthorized access.
Engineering Controls: Use local exhaust ventilation or appropriate containment to control airborne levels below recommended exposure limits.
Personal Protective Equipment: Wear safety goggles, gloves, and lab coat; use dust mask or respiratory protection if indicated by work conditions.
Exposure Limits: No established occupational exposure limits for 5-Hydroxy-L-Tryptophan.
Hygiene Measures: Wash hands and face thoroughly after handling and before eating or drinking.
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 293–296 °C (with decomposition)
Boiling Point: Decomposition occurs before boiling
Solubility: Slightly soluble in water, ethanol, and DMSO
pH: Neutral to slightly acidic in aqueous solutions
Vapor Pressure: Not applicable
Partition Coefficient: Log P (octanol/water) −2.5
Flash Point: No flash point determinable under normal conditions
Density: 1.54 g/cm³ at 25°C
Chemical Stability: Stable under normal temperatures and conditions; avoid elevated heat or direct sunlight exposure.
Hazardous Reactions: Can react with strong oxidizing agents forming hazardous byproducts.
Conditions to Avoid: Excessive heat, moisture, ultraviolet light (can accelerate decomposition).
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, and potentially toxic organic fragments on combustion or thermal breakdown.
Acute Toxicity: LD50 (oral, rat) > 2000 mg/kg; low acute oral toxicity
Chronic Effects: No comprehensive chronic toxicity data, but excessive prolonged intake linked in some studies to gastrointestinal discomfort, possible serotonin syndrome in sensitive individuals or combined with certain drugs.
Skin and Eye Irritation: Low potential for irritation, though individual sensitivity varies.
Respiratory Effects: Inhalation of dust may cause transient respiratory irritation.
Carcinogenicity/Mutagenicity: No evidence supporting carcinogenic or mutagenic risk under typical exposure.
Sensitization: Not classed as a skin sensitizer.
Ecotoxicity: Practically non-toxic to aquatic life at environmental concentrations; large quantities may change pH locally or add biological load.
Biodegradability: Readily biodegradable in soil and water over time.
Bioaccumulation Potential: Low; compound expected to not build up in animal tissue due to rapid metabolic breakdown.
Mobility in Soil: Moderately mobile; soluble residues can leach or disperse, especially in sandy soils.
Other Harmful Effects: None documented for common environmental exposure scenarios.
Disposal Requirements: Collect and package excess product, contaminated absorbents, and packaging for delivery to qualified hazardous or chemical waste disposal facility.
Waste Codes: Not regulated as hazardous waste under US RCRA or EU regulations.
Precautions: Do not pour chemical slurries or solutions into public drains or surface water; comply with local waste disposal regulations.
UN Number: Not regulated as dangerous goods
Transport Hazard Class: Not classified as hazardous for ground, air, or sea transport under international ADR/RID, IATA, IMO codes
Packing Group: Not applicable
Environmental Hazards: Not considered an environmental hazard in transport
Special Precautions: Ensure containers are intact, tightly closed, clearly labeled, and protected from impact or excessive vibration.
National Inventory Status: Listed in TSCA inventory, REACH compliant in EU, included in Canadian DSL, AICS in Australia, and similar major inventories worldwide.
Labeling: No mandatory hazard symbol, but safety advisory language recommended.
Workplace Use: No occupational exposure limit, but standard chemical hygiene and laboratory safety practices apply.
Other Regulations: Sale for human consumption as a dietary supplement may be controlled or restricted in some countries; always follow applicable health, safety, and import/export guidelines.
