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Product Name: 5-Difluoromethoxy-2-Mercapto-1H-Benzimidazole
Synonyms: DFMBI, 2-Mercapto-5-(difluoromethoxy)-1H-benzimidazole
CAS Number: 127832-09-3
Molecular Formula: C8H6F2N2OS
Molecular Weight: 216.21 g/mol
Recommended Use: Chemical intermediate, research
Supplier Identification: Example Chemicals Corp., 123 Innovation Way, Chicago, IL 60601 USA, +1-800-555-9191
GHS Classification: Acute Toxicity (Oral, Category 4); Skin Sensitization (Category 1); Eye Damage/Irritation (Category 2A); Aquatic Toxicity (Acute Category 2, Chronic Category 3)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin irritation; May cause an allergic skin reaction; Causes serious eye irritation; Toxic to aquatic life; May cause long-term adverse effects in the aquatic environment.
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid breathing dust, avoid release to the environment, wash thoroughly after handling, wear protective gloves/protective clothing/eye protection/face protection.
Chemical Identity: 5-Difluoromethoxy-2-Mercapto-1H-Benzimidazole
Common Name: Same as above
CAS Number: 127832-09-3
Concentration: >98%
Impurities: Possible trace benzimidazole derivatives and solvents <1% (non-hazardous)
General Advice: Seek medical attention immediately if symptoms persist.
Inhalation: Move to fresh air. If breathing is difficult, administer oxygen by qualified personnel. Seek medical assistance right away.
Skin Contact: Wash exposed area with soap and water for a minimum of 15 minutes. Remove contaminated clothing and wash before reuse. Consult a physician if irritation or sensitization occurs.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek immediate medical care if irritation persists.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Never give anything by mouth to an unconscious person. Call poison control or local emergency number for advice.
Suitable Extinguishing Media: CO₂, dry chemical, foam, or water spray designed for chemical fires
Unsuitable Extinguishing Media: Water jet, as it may spread burning material
Hazards from Combustion: May emit toxic fumes, including nitrogen oxides, sulfur oxides, carbon oxides, fluorine-containing gases
Protective Equipment: Wear full protective gear and self-contained breathing apparatus.
Fire Fighting Instructions: Move containers from fire area if safe. Remain upwind and prevent runoff into drains.
Personal Precautions: Avoid breathing dust. Avoid contact with skin, eyes, and clothing. Wear suitable protective equipment.
Environmental Precautions: Prevent entry into sewers, surface or ground water. Notify authorities if product contaminates environment.
Cleanup Methods: Scoop up without raising dust. Sweep or shovel material into a suitable container for proper disposal. Ventilate area and wash spill site after material pickup is complete.
Handling: Use in a chemical fume hood or well-ventilated area. If allergies or sensitivities have occurred with similar substances, take extra precautions. Avoid generation of dust and minimize contact.
Storage: Store tightly sealed in a cool, dry, well-ventilated place away from incompatible materials such as oxidizers and acids. Protect from direct sunlight and sources of ignition. Keep original container.
Engineering Controls: Use with local exhaust ventilation or in a fume hood to minimize exposure. Eyewash stations and safety showers required near handling area.
Personal Protective Equipment (PPE): Safety glasses or chemical splash goggles; chemical-resistant gloves (such as nitrile); laboratory coat; suitable respiratory protection if dust concentrations become significant.
Exposure Limits: No specific occupational exposure limits established.
General Hygiene Practices: Do not eat, drink, or smoke when handling. Wash hands thoroughly after use. Remove contaminated clothing and wash before reuse.
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic
pH: Not applicable (solid)
Melting Point: Approximately 175-178°C
Boiling Point: Not determined
Flash Point: Not determined
Flammability: May form combustible dust concentrations in air
Vapor Pressure: Negligible under normal conditions
Vapor Density: Not applicable
Solubility: Sparingly soluble in water; soluble in organic solvents such as DMSO and acetone
Partition Coefficient (log Kow): Not determined
Decomposition Temperature: Not determined
Viscosity: Not applicable
Chemical Stability: Stable under recommended handling and storage conditions.
Reactivity: Reacts with strong acids and oxidizing agents.
Possibility of Hazardous Reactions: No dangerous reactions known under normal conditions.
Conditions to Avoid: Excessive heat, moisture, sources of ignition.
Incompatible Materials: Oxidizing agents, acids, strong bases
Hazardous Decomposition Products: May release toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, and hydrogen fluoride.
Acute Toxicity: May cause harmful effects if swallowed, inhaled, or in contact with skin. Exact LD₅₀ values are not established, but data from similar benzimidazole derivatives suggest moderate toxicity.
Skin Corrosion/Irritation: Causes irritation and possible sensitization in susceptible individuals.
Serious Eye Damage/Irritation: Causes eye irritation, may result in redness, tearing or pain.
Respiratory or Skin Sensitization: Sensitization reactions have been reported with benzimidazole compounds.
Germ Cell Mutagenicity: No data available.
Carcinogenicity: No component present at levels greater than 0.1% identified as probable, possible, or confirmed human carcinogen by IARC, ACGIH, NTP, or OSHA.
Reproductive Toxicity: No information available for this material.
STOT-Single/Repeated Exposure: Not classified for specific target organ toxicity.
Aspiration Hazard: Not identified as an aspiration hazard.
Ecotoxicity: Toxic to aquatic organisms. Due to structural similarity with other benzimidazole derivatives, potential for chronic effects exists in aquatic environments.
Persistence and Degradability: Persistence likely in soil and water due to aromatic structure and fluorinated group.
Bioaccumulative Potential: Bioaccumulation not expected to be significant, but data are limited.
Mobility in Soil: Not highly mobile; may adsorb to soil/sediment particles.
Other Adverse Effects: Discharge into the environment must be avoided. Large spills may impact local ecology.
Waste Disposal: Collect and transfer to a suitable, labeled chemical waste container for disposal in accordance with local, regional, and national regulations. Do not dispose of via public sewers or municipal waste streams.
Contaminated Packaging: Dispose of as unused product. Decontaminate containers before recycling or disposal.
Special Precautions: Avoid uncontrolled surface or groundwater releases.
UN Number: Not regulated for transport as hazardous material under standard international transport regulations.
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Avoid accidental release during transport; product remains toxic to aquatic organisms.
Special Precautions: Secure and seal containers; prevent movement or vibration during transit that could result in spillage or dust generation.
OSHA Status: Not specifically regulated; handle as a hazardous chemical
SARA Title III Sections 302/304, 311/312, 313: Not subject to reporting requirements under SARA Titles; general chemical inventory compliance applies
TSCA Inventory: Listed or exempt
EU Regulations: REACH registration may be required for use in EEA; non-classified for Workplace Exposure Limit (WEL) in UK
Canada: DSL/NDSL listing should be checked
Other Information: Always refer to local, federal, provincial/state rules as regulations and chemical status may change.
