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Product Name: 5,6,7,8-Tetrahydro-1-Naphthylamine
Chemical Formula: C10H13N
CAS Number: 2243-62-1
Synonyms: 1-Amino-5,6,7,8-tetrahydronaphthalene, Tetrahydronaphthylamine
Recommended Uses: Laboratory chemical, research, synthesis
Manufacturer: Supplied upon request through standard chemical distributors
Contact Information: Emergency assistance and technical data through local poison control and supplied manufacturer phone numbers
Emergency Numbers: Local poison control centers and regional fire departments, listed on supplier shipping documents
GHS Classification: Acute toxicity (Oral, Dermal), Skin irritation, Serious eye irritation, Specific target organ toxicity, Category determined by regulatory guidance
Label Elements: Signal word: Warning; Pictograms: Exclamation Mark
Hazard Statements: Harmful if swallowed. Harmful in contact with skin. Causes skin and eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust, fumes or vapors. Wash thoroughly after handling. Use gloves, safety glasses, and lab coats. Avoid unprotected contact with eyes or skin.
GHS Physical Hazards: Not classified for physical hazard
Hazards Not Otherwise Classified: Prolonged exposure could affect nervous system or organs
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Potential Health Effects: Irritation of skin and eyes. May induce cough, nausea, dizziness, and headaches upon inhalation of vapors or dust.
Chemical Identity: 5,6,7,8-Tetrahydro-1-Naphthylamine
CAS Number: 2243-62-1
Purity: Usually supplied at >97% assay by suppliers
Impurities: Minor secondary aromatic amines, hydrogenated derivatives, water content negligible for purity >97%
Other Additives: None intentionally added. Trace solvents possible if shipped as a solution.
Molecular Weight: 147.22 g/mol
Eye Contact: Flush thoroughly with water for at least 15 minutes. Remove contact lenses if present. Seek medical attention if irritation persists.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water. Use soap if available.
Inhalation: Move individual to fresh air. Keep at rest. Get medical attention if symptoms continue.
Ingestion: Rinse mouth with water. Do not induce vomiting. Call medical help or poison control immediately.
Advice for Medical Personnel: Treat symptomatically. Monitor for respiratory or neurological symptoms.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or foam. Water spray can cool exposed containers.
Specific Hazards in Fire: May release irritating or toxic gases such as nitrogen oxides and carbon monoxide under combustion.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus (SCBA), full protective gear.
Special Firefighting Procedures: Move containers from fire area if safe. Use water spray for cooling. Avoid runoff into sewers.
Explosion Sensitivity: Not classified as explosive, but dust or vapor presence in enclosed space can pose danger in severe fire conditions.
Personal Precautions: Evacuate unnecessary personnel. Avoid inhalation of dust or vapor. Wear gloves and chemical-resistant goggles.
Environmental Precautions: Prevent product from entering drains, soil, or waterways. Alert environmental authorities if large spill enters the environment.
Methods for Cleanup: Absorb with non-combustible absorbents (sand, earth, diatomaceous earth). Sweep up and collect for disposal.
Decontamination: Wash spilled area with soap and water after removal. Ventilate area.
Disposal: Place waste in appropriate chemical disposal containers for licensed hazardous waste treatment.
Safe Handling: Work in a well-ventilated location. Do not eat, drink, or smoke in areas where handled.
Personal Hygiene: Wash hands thoroughly after use. Remove and wash contaminated clothing before reuse.
Storage Conditions: Store in tightly closed original container in cool, dry, well-ventilated place. Keep away from incompatible substances—acids, oxidizers.
Incompatible Materials: Avoid contact with strong acids, oxidizing agents; possible reactivity issues reported in literature.
Packaging Recommendations: Use containers resistant to aromatic amines, such as glass or lined metal drums.
Occupational Exposure Limits: No established ACGIH or OSHA values; hold to general aromatic amine guidance, minimize exposure as much as feasible.
Engineering Controls: Use fume hood, safety showers, eyewash stations, exhaust ventilation to keep airborne levels low.
Personal Protective Equipment (PPE): Wear NIOSH-approved respiratory protection for scattered dust or fume. Use nitrile or neoprene gloves. Laboratory coats or chemical aprons strongly advised. Safety goggles or face shield for eye protection.
General Hygiene: Change out of contaminated clothing. Avoid direct skin contact. Maintain strict laboratory cleanliness.
Appearance: White to pale yellow crystalline solid
Odor: Mild amine-type odor
Melting Point: Reported range: 55–58°C
Boiling Point: About 255–265°C at reduced pressure
Density: About 1.07 g/cm³ at 25°C
Solubility: Slightly soluble in water, more soluble in alcohols and organic solvents
Vapor Pressure: Negligible at room temperature
pH (solution): Not applicable for solid
Partition Coefficient (log Kow): Estimated 2–3 based on amine structure
Viscosity: Not applicable
Flash Point: >110°C (closed cup, estimated)
Auto-ignition Temperature: Not tested
Explosive Limits: Not readily determinable for vapors
Chemical Stability: Stable under normal lab storage and handling temperature. Avoid excessive heat, light exposure.
Conditions to Avoid: Sources of ignition, incompatible chemicals, moisture if purity or stability could be affected.
Incompatible Substances: Strong acids, oxidizers (such as hydrogen peroxide, nitric acid), chloroformates; forms hazardous byproducts.
Hazardous Decomposition: Nitrogen oxides, low molecular weight amines, carbon monoxide upon combustion or severe decomposition.
Polymerization: Not expected under recommended conditions; literature supports thermal and chemical stability up to moderate temperatures.
Acute Toxicity: Oral LD50 (rat) estimated 200–500 mg/kg; Toxicity data based on structural analogues.
Skin Corrosion/Irritation: Causes mild to moderate irritation; prolonged exposure may worsen.
Eye Damage/Irritation: Causes moderate irritation, redness, tearing.
Respiratory Sensitization: May irritate respiratory tract—do not inhale dust.
Skin Sensitization: Limited reports; handle as a possible sensitizer.
Chronic Toxicity: Prolonged or repeated exposure could affect liver, kidneys, or nervous system functions.
Carcinogenicity: Not listed by IARC, US NTP, or OSHA. Tertiary amines may raise suspicion; always exercise caution.
Mutagenicity and Reproductive Toxicity: No specific data; prudent practice: avoid unnecessary exposure.
Other Information: Individuals with pre-existing conditions (respiratory, skin disorders) may be at increased risk from exposure.
Ecotoxicity: Limited direct data; structurally similar amines can be toxic to aquatic organisms at high concentrations.
Persistence and Degradability: Partial biodegradability expected; full breakdown in environment may take time, and intermediate degradation products may appear.
Bioaccumulation Potential: Moderate, based on log Kow and structure.
Mobility in Soil: Likely to exhibit moderate mobility; binds to soil matrix due to structure.
Other Adverse Effects: Avoid discharge into waterways; follow chemical waste protocols as precautionary measure due to limited breakdown and persistence.
Methods of Disposal: Follow local, regional, or national regulations for hazardous chemical waste. Incinerate in licensed facility if appropriate.
Contaminated Packaging: Rinse with compatible solvent, dispose of as chemical waste. Glass, plastic, or lined metal containers may require restrictive handling.
Precautions: Reuse or recycle containers only after thorough decontamination and inspection.
Handling of Waste: Wear PPE for all handling; prevent environmental release.
Do Not: Dispose down the drain or regular refuse streams.
UN Number: Not specifically assigned; check local hazardous materials transport regulations
Proper Shipping Name: Laboratory chemical, n.o.s. (not otherwise specified), Amine derivative
Transport Hazard Class: Included under Class 6.1 (Toxic substances) if transported in bulk or under international regulations
Packing Group: III (if applicable—moderate hazards)
Environmental Hazards: Not marine pollutant under GHS; caution advised for spill response
Special Precautions: Clearly mark containers. Secure packaging. Carry documentation of technical description and hazard classification.
US Regulations: TSCA listed; not subject to SARA 313 or CERCLA reporting thresholds as specific compound
Europe: Registered or exempt under REACH, notification may be required for quantities over 1 ton/year
Other International Standards: Comply with local chemical inventory requirements in workplace jurisdiction
Workplace Controls: Subject to employer’s chemical hygiene plan, training, recordkeeping, and safe use policies according to OSHA Laboratory Standard
Labeling: Follow GHS, OSHA, and EU CLP regulations for hazard pictograms and signal words
Additional Restrictions: Monitor industry bulletins for updates; periodic review of regulatory status recommended.
