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Product Name: 4-Vinylpyridine
CAS Number: 100-43-6
Synonyms: 4-Ethenylpyridine, p-vinylpyridine, 1-vinyl-4-pyridine
Recommended Uses: Intermediate for chemical manufacturing, polymer synthesis, research applications
Supplier: [Manufacturer’s Contact Details Required]
Emergency Contact: Chemtrec 1-800-424-9300 (US)
GHS Classification: Flammable liquid (Category 3), Acute toxicity–oral (Category 3), Skin irritation (Category 2), Eye irritation (Category 2A), Acute aquatic toxicity (Category 3)
Danger Symbol: Flame, Exclamation mark
Signal Word: Danger
Hazard Statements: Harmful if swallowed, flammable liquid and vapor, causes skin and serious eye irritation, toxic to aquatic life
Precautionary Statements: Keep well away from heat, sparks, open flames; avoid breathing vapors; wash thoroughly after handling; use only outdoors or in well-ventilated area; avoid release to the environment
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: 4-Vinylpyridine
Percentage: >98%
Molecular Formula: C7H7N
Molecular Weight: 105.14 g/mol
Impurities/ Additives: May contain trace inhibitors (for example, tert-butylcatechol at <0.1%) to prevent polymerization
Inhalation: Move exposed person to fresh air. Restore breathing if necessary and seek medical help right away. Remove any contaminated clothing.
Skin Contact: Wash thoroughly with soap and water for at least 15 minutes. Get medical advice if irritation persists. Remove contaminated clothing and shoes, then launder before reuse.
Eye Contact: Rinse eyes immediately with plenty of water, lifting upper and lower eyelids occasionally. Seek medical attention if irritation or redness continue.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting unless advised by medical personnel. Seek medical care as soon as possible.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam. Water spray can cool exposed containers, but avoid direct stream which can spread fire.
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen cyanide
Special Protective Equipment: Firefighters require self-contained breathing apparatus and protective gear to limit exposure to vapors and combustion gases.
Unusual Fire Hazards: Vapors may form explosive mixtures with air. Product can produce irritating and toxic fumes in a fire.
Personal Precautions: Evacuate poorly ventilated areas. Eliminate all ignition sources. Ventilate spill area. Use proper protective equipment (respirator, gloves, goggles, protective clothing).
Environmental Precautions: Prevent from entering drains, soil, surface and groundwater. Notify authorities in case of major spill.
Clean Up Methods: Absorb spill with inert material (sand, earth, vermiculite). Sweep up and place in a suitable container for proper waste disposal. Decontaminate area with water and detergent.
Handling: Keep containers tightly closed. Use in well-ventilated spaces to minimize vapor inhalation risk. Ground all equipment for static discharge protection. Do not handle near open flames, sparks, or hot surfaces.
Storage: Store in cool, dry, fireproof area out of direct sunlight. Keep away from strong acids, alkalis, and oxidizers. Avoid temperatures above 25°C (77°F). Store in original, clearly labeled containers. Check regularly for leaks and expiration of stabilizers.
Exposure Limits: No specific OSHA PEL or ACGIH TLV assigned; minimize exposure as much as possible.
Engineering Controls: Install local exhaust ventilation and process enclosures to minimize vapor concentrations. Laboratory chemical fume hood use encouraged.
Personal Protective Equipment:
- Respiratory: NIOSH-approved organic vapor respirators if exposure limits risk being exceeded
- Skin: Chemical resistant gloves (butyl rubber, nitrile, neoprene recommended) and long sleeves/lab coat
- Eyes: Chemical splash goggles or face shield
- Other: Emergency eyewash and safety shower in work area
Appearance: Clear, colorless to pale yellow liquid
Odor: Fishy, amine-like odor
Melting Point: -38°C (-36.4°F)
Boiling Point: 148°C (298.4°F)
Flash Point: 57°C (135°F)
Evaporation Rate: Not available
Flammability: Flammable
Vapor Pressure: 1.3 mm Hg at 25°C
Vapor Density (air=1): 3.7
Specific Gravity: 0.976 at 20°C
Solubility: Miscible with water, alcohols, ether
pH: Not determined
Partition Coefficient (n-octanol/water): 1.16
Autoignition Temperature: 445°C (833°F)
Chemical Stability: Stable under recommended storage and handling conditions. May polymerize if exposed to heat, light, or without stabilizers.
Possibility of Hazardous Reactions: Polymerization can occur violently in presence of high temperatures, peroxides, or absence of inhibitors.
Incompatible Materials: Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides
Hazardous Decomposition Products: Toxic vapors such as nitrogen oxides, carbon monoxide, carbon dioxide.
Conditions to Avoid: Heat, sunlight, open flame, lack of inhibitor.
Acute Toxicity: Oral LD50 (rat): 150 mg/kg
Inhalation: Vapors irritate respiratory tract, can cause nausea, headache, dizziness at high concentrations.
Skin: Causes moderate to severe irritation.
Eyes: Causes pain, irritation, watering, redness.
Chronic Exposure: Prolonged exposure can cause skin sensitization and allergic reactions.
Mutagenicity: Positive in several microbial assays.
Carcinogenicity: Not classified as a human carcinogen by IARC, NTP, or OSHA.
Reproductive Toxicity: No significant data in humans, animal studies inconclusive.
Toxicity to Aquatic Life: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence/Degradability: Not extensively bio-degradable under typical environmental conditions.
Bioaccumulation Potential: Low to moderate based on partition coefficient data.
Mobility in Soil: Product is mobile in soil and can contaminate groundwater.
Other Adverse Effects: No ozone depletion or global warming potential identified.
Waste Disposal Methods: Incinerate in approved facility or dispose according to local, regional, and national regulations. Do not release to sewer, surface, or ground water.
Contaminated Packaging: Triple-rinse containers before offering for recycling or disposal. Follow label and regulatory requirements.
Special Precautions: Avoid uncontrolled discharge, wear appropriate protective equipment during disposal.
UN Number: UN 2810
UN Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (contains 4-vinylpyridine)
Transport Hazard Class(es): 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant
Transport in Bulk: Not recommended except in approved containers.
Special Precautions for User: Ensure containers remain well sealed and upright. Follow all local, national, and international regulations for hazardous materials transport.
OSHA HazCom Standard: Hazardous chemical, full compliance required
TSCA Listing: Listed on US TSCA Inventory
EINECS/ELINCS: Listed (EINECS No. 202-848-9)
Canada DSL/NDSL: Listed on DSL
SARA Title III: Section 313 subject chemical
WHMIS Classification: D1B (Toxic), B2 (Flammable)
California Prop 65: Not listed
Other Regulatory Information: Local and international workplace, safety, and environmental regulations apply. Users should check regional requirements prior to acquisition, use, or transport.
