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Product Name: 4-Toluidine Hydrochloride
Other Names: p-Toluidine hydrochloride, para-Toluidine hydrochloride
CAS Number: 636-21-5
EC Number: 211-245-2
Molecular Formula: C7H10ClN
Molecular Weight: 143.62 g/mol
Recommended Use: Intermediate for dyes, research, lab reagent
Supplier Details: Refer to manufacturer for contact and address
Emergency Phone: Local poison center or national emergency numbers
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritant, suspected carcinogen
Hazard Pictograms: Skull and crossbones, exclamation mark, health hazard
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic if inhaled, may cause skin irritation, may cause eye irritation, suspected of causing cancer
Precautionary Statements: Avoid breathing dust or vapors, wear protective equipment, wash hands after handling, do not eat or drink while using
Potential Health Effects: Exposure can cause respiratory irritation, dizziness, headaches, nausea, damage to blood, kidneys, or liver after repeated contact
Chemical Name: 4-Toluidine Hydrochloride
Synonyms: para-Toluidine hydrochloride
CAS Number: 636-21-5
Concentration: 98-100%
Impurities: Trace-level possible, unregulated ingredients not anticipated
Stabilizers/Preservatives: None reported
Inhalation: Move person to fresh air, provide oxygen if breathing is difficult, seek immediate medical attention
Skin Contact: Remove contaminated clothing, wash affected skin with plenty of water and soap, consult a physician if irritation persists
Eye Contact: Rinse eyes continuously with water for at least 15 minutes, lift eyelids, remove contact lenses if present, get medical help right away
Ingestion: Rinse mouth without swallowing, do not induce vomiting, never give anything by mouth to an unconscious person, contact poison control immediately
Symptoms: Shortness of breath, coughing, skin reddening, headaches, blue tint on lips or nail beds, confusion, dizziness
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or alcohol-resistant foam
Specific Hazards: Gives off irritating or toxic gases, such as hydrogen chloride, nitrogen oxides, and carbon monoxide when burned
Advice for Firefighters: Wear self-contained breathing apparatus, full protective clothing, keep containers cool with water spray
Fire/Explosion Hazard: Dust may form explosive mixture in air, avoid thermal decomposition
Special Procedures: Avoid runoff from fire control entering drains or waterways
Personal Precautions: Evacuate area, avoid breathing dust, use proper respiratory and skin protection
Environmental Precautions: Prevent further leakage or spillage, do not allow runoff to reach sewers, water bodies, or soil
Methods for Cleaning Up: Sweep up material without generating dust, place in suitable, sealed containers for proper disposal, ventilate area, wash spill site after material pickup
Reporting: Notify health, safety, or environmental authorities if significant amounts are released
Safe Handling Advice: Avoid contact with skin, eyes, and clothing, use personal protective equipment, prevent dust generation and accumulation, wash hands thoroughly after handling
Storage Conditions: Keep container tightly closed in a cool, dry, well-ventilated place away from acids, oxidizers, and foodstuff
Incompatible Materials: Strong oxidizers, acids, reducing agents, bases
Hygiene Measures: No eating, drinking, or smoking during use, store separately from household and incompatible chemicals
Occupational Exposure Limits: Consult regional, govemment or local exposure standards for workplace limits, avoid exposures above recommended values
Engineering Controls: Use chemical fume hood, adequate local exhaust to minimize dust exposure
Eye/Face Protection: Safety goggles or face shield
Skin Protection: Chemical-resistant gloves, lab apron or protective clothing
Respiratory Protection: Suitable mask or respirator for dusts or contaminated atmospheres
Workplace Controls: Wash hands before breaks and after use, remove contaminated clothing immediately
Appearance: White to pale pink crystalline powder
Odor: Slightly aromatic or amine-like
Odor Threshold: No data available
pH: 4–6 (10g/L water at 20°C)
Melting Point: 230–240°C (decomposition occurs)
Boiling Point: Decomposes before boiling
Solubility: Soluble in water
Density: About 1.2 g/cm³
Partition Coefficient (n-octanol/water): No data available
Vapor Pressure: Negligible at room temperature
Viscosity: Not applicable
Evaporation Rate: Not applicable
Decomposition Temperature: Above 230°C
Flash Point: Not flammable in solid state
Stability: Stable under normal conditions of storage and use
Reactivity: Non-reactive at room temperature in dry, inert environments
Conditions to Avoid: High temperatures, open flames, sources of ignition, moisture
Materials to Avoid: Strong oxidizing agents, acids, bases, reducing substances
Hazardous Decomposition Products: Hydrogen chloride gas, carbon monoxide, carbon dioxide, nitrogen oxides, various organochlorinated compounds on thermal decomposition
Hazardous Polymerization: Does not occur
Corrosivity: Non-corrosive to metals under recommended storage
Acute Toxicity: Harmful to swallow, inhale, or in contact with skin; LD50 oral (rats): 750 mg/kg
Skin Corrosion/Irritation: Causes mild to moderate skin irritation on contact
Serious Eye Damage/Irritation: Causes irritation, temporary pain, possible corneal injury
Respiratory Sensitization: May cause respiratory tract irritation when dust or fumes inhaled
Carcinogenicity: Classified as a possible human carcinogen by IARC (Group 2B), some evidence in animal studies
Reproductive Toxicity: Not enough information; precaution advised
Specific Target Organ Toxicity: Blood, kidneys, liver can be affected by repeated exposure
Other Effects: Can cause methemoglobinemia, resulting in cyanosis, fatigue, headache
Eco-toxicity: Toxic to aquatic life, risk of damaging algae, invertebrates, and fish at high concentrations
Persistence and Degradability: Slowly biodegraded in environment, risk of accumulation
Bioaccumulation Potential: Unlikely to significantly bioaccumulate due to water solubility
Mobility in Soil: Expected to be mobile in moist soil due to water solubility
Other Effects: Avoid release into surface water, sewage, soil; adverse effects expected for aquatic organisms even at low levels
Regulatory Reporting: Some regions require immediate notification of environmental discharges
Waste Disposal Methods: Treat as hazardous waste, follow federal, state, and local guidelines for chemical disposal, do not mix with common trash or pour down the drain
Contaminated Packaging: Empty containers must be treated as hazardous, triple rinse, dispose through licensed hazardous waste handler
Incineration: Considered safe if conducted in a chemical incinerator equipped with scrubbers to prevent emission of gases
Disposal Precautions: Label waste packages clearly, store waste in sealed drums until collection
Recommendations: Consult waste authority or chemical supplier for guidance
UN Number: 2811 (Toxic solid, organic, n.o.s., containing 4-Toluidine Hydrochloride)
UN Proper Shipping Name: Toxic solid, organic, n.o.s.
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (minor hazard)
Labels: Toxic
Environmental Hazards: Dangerous to aquatic environment; special handling required
Special Precautions for User: Keep away from incompatible substances, secure containers for transport to prevent leaks
Transport Regulations: Refer to local, national, and international transportation guidelines (ADR, IMDG, IATA)
Safety, Health, and Environmental Regulations: Subject to regional, national, and international chemical safety regulations
OSHA: Classified as hazardous; standard hazard communication applies
TSCA: Listed on the Toxic Substances Control Act Inventory
REACH Registration: Supply chain tracking under REACH regulation in Europe
SARA Title III: Subject to immediate notification for accidental release under some circumstances
DSL/NDSL (Canada): Listed/regulated
Other Relevant Regulations: Controlled for workplace exposure, disposal, and transportation due to carcinogenic and toxic potential
Labeling: Must carry hazard pictograms and warning statements in accordance with GHS
