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Product Name: 4-Tert-Butylphenol
Chemical Formula: C10H14O
CAS Number: 98-54-4
Synonyms: PTBP, 4-tert-Butylphenol, p-tert-Butylphenol
Recommended Use: Used in resins, varnishes, dyes, and as a chemical intermediate
Manufacturer: Details depend on supplier, consult supplied MSDS sheets
Contact: Refer to supplier's emergency number and address
Emergency Telephone: Check on distributed document by supplier
Hazard Classification: Eye damage/irritation Category 1, Skin irritation Category 2, Acute toxicity (oral, dermal, inhalation) Category 4, Hazardous to aquatic environment - acute Category 1, chronic Category 2
Signal Word: Danger
Hazard Statements: Causes serious eye damage, May cause respiratory irritation, Toxic to aquatic life with long lasting effects, Causes skin irritation, Harmful if swallowed or inhaled
Pictograms: Corrosive, Exclamation mark, Environment
Precautionary Statements: Avoid breathing dust/fumes, Wear protective gloves/eye protection, Wash hands thoroughly after handling, Do not release to the environment, Use only outdoors or in well-ventilated area
Specific Target Organ Toxicity: May cause damage to eyes and skin
Chemical Name: 4-Tert-Butylphenol
Concentration: 99% or more (commercial purity often above 98%)
Impurities: May include low levels of phenol derivatives; trace impurities depend on specific manufacturer
Other Ingredients: None present at concentrations that contribute to hazard
Inhalation: Move to fresh air, keep at rest, seek medical attention if symptoms persist (such as coughing, choking, breathing difficulty, sore throat)
Skin Contact: Remove contaminated clothing and wash skin thoroughly with plenty of water for at least 15 minutes, use soap if available, seek medical advice for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and get immediate medical advice, permanent eye injury may result without prompt action
Ingestion: Rinse mouth, do not induce vomiting, drink water slowly, seek immediate medical attention, show MSDS or chemical container to emergency personnel
Most Important Symptoms/Effects: Severe eye injury, skin burns, gastrointestinal discomfort, respiratory tract irritation
Suitable Extinguishing Media: Use foam, dry chemical powder, carbon dioxide, or water spray (do not use strong jets of water as these may spread the chemical)
Specific Hazards Arising from Chemical: Emits toxic fumes of carbon oxides on combustion; can release irritating and corrosive vapors
Protective Equipment for Firefighters: Use self-contained breathing apparatus, chemical protective suit, gloves and boots
Firefighting Instructions: Approach from upwind, remove containers from area if safe, avoid water runoff into drains
Explosion Hazard: Not explosive, but can combust with strong oxidizers
Special Hazards: Heated containers may rupture; residue and vapors can re-ignite
Personal Precautions: Wear protective clothing including gloves, safety goggles, face shield, chemical-resistant footwear, avoid inhaling fumes or direct contact with skin or eyes
Environmental Precautions: Prevent chemical run-off into drains, sewers or waterways, notify authorities if a large spill enters environment
Clean-Up Methods: Scoop or sweep spilled material into suitable, labelled containers for disposal, absorb small quantities with inert material such as sand or earth, wash affected area with large amounts of water after bulk removal, ventilate area
Decontamination: Do not allow tools or implements to remain contaminated; clean properly after use
Emergency Procedures: Keep unauthorized people away until clean-up is complete
Handling: Use only in well-ventilated areas, avoid contact with skin and eyes, keep chemicals in original container, use chemical fume hoods if possible, avoid breathing vapors/dust
Storage: Store in cool, dry, well-ventilated area away from direct sunlight, heat, and sources of ignition, keep container tightly closed, segregate from acids, oxidizers, and foodstuffs
Specific End Uses: For industrial and laboratory use under controlled conditions
Incompatible Materials: Strong oxidizing agents, strong acids, halogens, anhydrides
Additional Protection: Install spill control and eye wash stations in storage and work areas
Engineering Controls: Provide adequate local exhaust ventilation, safety showers, closed-system transfer if possible
Exposure Limits: No specific occupational exposure limits established globally; minimize exposure as a potential irritant
Respiratory Protection: Wear approved respirator if exposure to vapors or dust is likely
Eye Protection: Tight-fitting chemical safety goggles or full face shield
Skin Protection: Chemical-resistant gloves (nitrile or neoprene), long sleeves, lab apron or chemical suit
Hygiene Measures: Wash hands before eating, smoking, or using restroom, do not eat or drink in areas where substance is handled
Environmental Exposure Controls: Prevent release to environment through spill containment and correct disposal procedures
Appearance: White to light yellow crystalline solid
Odor: Characteristic phenolic odor, sometimes described as medicinal
Odor Threshold: Not defined (irritant properties can be detected at low levels)
pH: Not available
Melting Point: 98–103°C
Boiling Point: 237–240°C
Flash Point: 113–120°C (closed cup method)
Evaporation Rate: Not established
Flammability: Combustible solid, burns with smoky flame
Vapor Pressure: Very low at room temperature
Vapor Density: 5.07 (air = 1)
Relative Density: 0.89–0.91 g/cm³
Solubility: Slightly soluble in water; soluble in organic solvents such as alcohol, benzene, and ether
Partition Coefficient (n-octanol/water): log Kow: 3.33
Autoignition Temperature: Not determined
Decomposition Temperature: Above 200°C
Viscosity: Not applicable (solid at room temperature)
Molecular Weight: 150.22 g/mol
Chemical Stability: Stable under standard storage and handling conditions
Reactivity: Reacts with strong acids, oxidizing agents, and some anhydrides
Hazardous Reactions: Can polymerize or decompose violently in presence of strong oxidizers
Conditions to Avoid: High temperatures, direct sunlight, open flame, sparks, incompatible substances
Incompatible Materials: Strong oxidizing agents (peroxides, chlorates), sulfuric acid, nitric acid, acid anhydrides
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, phenolic compounds, irritating and toxic fumes
Polymerization: Will not occur under normal industrial conditions
Acute Toxicity: Oral LD50 (rat): 3250 mg/kg; Dermal LD50 (rat): 2288 mg/kg, Inhalation LC50: Data not well established
Skin Irritation: Causes moderate to severe irritation, risk of burns and dermatitis
Eye Damage: Causes serious eye damage, risk of permanent loss of vision
Respiratory Irritation: Prolonged exposure can irritate mucous membranes of nose and throat
Ingestion Effects: May lead to gastrointestinal pain, nausea, vomiting, abdominal cramps
Sensitization: Can provoke allergic response in sensitized individuals
Chronic Effects: Long-term or repeated exposure can lead to skin sensitization and dermatitis, possible liver and kidney effects
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity: In vitro data do not suggest mutagenicity at tested concentrations
Reproductive Toxicity: Insufficient evidence in humans or animals
Aquatic Toxicity: Very toxic to aquatic organisms, LC50 (fish, 96hr): 2.5 mg/L; EC50 (Daphnia, 48hr): 3 mg/L; can damage aquatic habitats
Persistence and Degradability: Partial biodegradation observed in water and soil; may persist in sediment
Bioaccumulative Potential: High due to log Kow >3; potential to build up in aquatic food chains
Mobility in Soil: Moderately mobile, may migrate to groundwater only to a limited extent
Other Adverse Effects: Disrupts aquatic ecosystems, can cause toxicity in non-target species at low concentrations, strong hazard to algae
Waste Treatment Methods: Dispose of as hazardous waste in accordance with local, national, and international regulations, incineration is preferred route
Disposal of Packaging: Empty containers may retain hazardous residue, must be disposed of as hazardous waste, reconditioning or reuse not advised
Special Precautions: Do not pour into drains or waterways, avoid release to the environment, do not mix in unapproved landfills
Disposal Guidance: Use licensed chemical waste contractor, retain documentation for regulatory compliance
UN Number: 2430
UN Proper Shipping Name: 4-tert-Butylphenol
Transport Hazard Class: 8 – Corrosive substances
Packing Group: III
Environmental Hazard: Marine pollutant
Special Precautions for User: Avoid spillage and keep containers upright, label and seal containers according to international transport regulations
Transport Labels: Corrosive, Marine pollutant mark
Regulated by: ADR/RID (land), IMDG (sea), IATA (air)
Labeling Requirements: Corrosive, environmental hazard, comply with national chemical safety labeling laws
OSHA: Falls under Hazard Communication Standard as hazardous chemical
TSCA: Listed in US Toxic Substances Control Act Inventory
ECHA: Listed on European Union REACH regulation, subject to safety data sheet provision
Other National Inventories: Listed in AICS (Australia), DSL/NDSL (Canada), ENCS (Japan), PICCS (Philippines), ECL (Korea)
Risk Phrases: R34 (Causes burns), R50/53 (Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment)
Safety Phrases: S26, S36/37/39, S61 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing, gloves, and eye/face protection; Avoid release to the environment)
Restriction: Subject to workplace exposure monitoring and controls according to local law
