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Product Name: 4-Nitroso-N,N-Dimethylaniline
Chemical Formula: C8H10N2O
CAS Number: 99-59-2
EC Number: 202-769-6
Synonyms: p-Nitrosodimethylaniline; N,N-Dimethyl-4-nitrosoaniline
Intended Use: Laboratory reagent, chemical synthesis, dye intermediate
Supplier Identification: Manufacturer or distributor address and emergency contact number needed for clear communication in the case of incidents
Classification: Acute oral toxicity (Category 3), Skin irritation (Category 2), Eye irritation (Category 2A), Suspected of causing cancer (Category 2); Hazardous to aquatic life (Category 3)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; causes skin and eye irritation; suspected of carcinogenic effects; harmful to aquatic organisms
Pictograms: Skull and crossbones, exclamation mark, health hazard
Route of Exposure: Inhalation, ingestion, skin and eye contact
Precautionary Statements: Avoid all unnecessary exposure, keep away from open flames, food, and animals, wash thoroughly after handling, use only outdoors or in a well-ventilated area
Chemical Name: 4-Nitroso-N,N-Dimethylaniline
Concentration: >98% pure
Impurities and stabilizing additives: Trace related aromatic amines or nitroso compounds possible due to synthesis
Other Information: Not mixed with additional solvents unless specified, absence of intentional additives
Molecular Weight: 150.18 g/mol
Inhalation: Move to fresh air, seek medical attention if symptoms persist, provide oxygen if breathing feels difficult
Skin Contact: Remove contaminated clothing, wash affected area with soap and plenty of water for at least 15 minutes, consult a physician
Eye Contact: Rinse cautiously with water for up to twenty minutes, remove contact lenses if present and easy, avoid rubbing, get medical help
Ingestion: Do not induce vomiting, rinse mouth with water, seek medical attention immediately, do not offer anything by mouth to an unconscious person
Symptoms/Effects: Burning sensation, nausea, dizziness, headache, skin or eye redness, possible difficult breathing, delayed symptoms possible
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide; water spray can be used for cooling but avoid water jets
Unsuitable Media: Strong water jets might disperse chemical
Specific Hazards: Releases toxic fumes of nitrogen oxides and carbon monoxide under combustion
Protective Equipment: Firefighters need self-contained breathing apparatus, full protective gear
Fire/Explosion Risk: Moderate, though not highly flammable; closed containers exposed to fire can rupture violently
Additional Info: Move undamaged containers from fire area, avoid breathing fumes, keep away from runoff to prevent environmental spread
Personal Precautions: Wear appropriate protective equipment including gloves, goggles, lab coat, NIOSH-approved respirator
Environmental Precautions: Contain spillage, avoid contamination of water sources and soil, do not allow to enter drains
Methods for Clean Up: Absorb spill with inert material like vermiculite or sand, place in sealed chemical waste container, dispose as hazardous waste
Decontamination: Wash spill area with soap and water after material pick-up
Additional Measures: Use ventilation in enclosed areas, restrict access to spill site, notify designated personnel immediately
Handling: Use only in fume hood or well-ventilated area, avoid contact with skin and eyes, prevent inhalation of dust or vapors, wear standard chemical-resistant PPE, keep away from heat, sparks, and open flame
Storage Conditions: Store at ambient temperature, dry, tightly-closed containers, protect from light, segregate from incompatible substances (strong oxidizers, acids, alkalis), label area clearly for hazardous chemicals
Incompatibilities: Reacts with oxidizing agents, strong acids, and strong bases
Special Requirements: Keep storage area secure, maintain proper ventilation, post warning signage, periodic inspection for container integrity
Exposure Limits: No established ACGIH or OSHA limits known
Engineering Controls: Use chemical fume hoods, local exhaust ventilation
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, lab coat, half-mask respirator with organic vapor cartridge (if exposure risk is present)
Hygiene Measures: Wash hands thoroughly before breaks and after handling, avoid eating or drinking in area
Other Protection: Ensure eyewash stations and safety showers are easily accessible
Appearance: Solid, crystalline powder, often yellow or greenish
Odor: Faint amine-like odor
Melting Point: 137-140°C
Boiling Point: Not readily available, decomposes before boiling
Solubility: Limited solubility in water; good solubility in most organic solvents
Vapor Pressure: No significant vapor pressure at room temperature
Density: Approx. 1.10-1.15 g/cm³
Flash Point: Not determined, but unlikely to be low
pH: Not applicable (neutral compound in solid form)
Chemical Stability: Stable under recommended storage; avoid sunlight, moisture
Chemical Stability: Stable in original packaging, protected from light
Incompatible Materials: Oxidizing agents, strong acids and bases can trigger hazardous decomposition
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, and possibly toxic nitroso or amine derivatives
Conditions to Avoid: Exposure to heat, moisture, light, and reactive chemicals
Polymerization: Not expected to occur under normal handling
Potential Routes of Exposure: Inhalation, ingestion, dermal and eye contact
Acute Effects: Toxic if swallowed, skin and respiratory tract irritation, eye damage possible
Chronic Effects: Possible carcinogenicity (IARC listed as Group 2B: possibly carcinogenic to humans)
LD50 (Oral, rat): Approx. 175 mg/kg
Symptoms: Headache, nausea, dizziness, fatigue, methemoglobinemia
Sensitization: Not known to cause skin sensitization, but repeated exposure can increase risk
Mutagenicity/Carcinogenicity: Evidence of genotoxicity in some animal studies, more research ongoing
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence & Degradability: Not readily biodegradable, can persist in nature
Bioaccumulation: Potential for bioaccumulation exists due to chemical structure
Mobility: Low water solubility limits movement through soil, but spills risk local contamination
Additional Hazards: Discharges can threaten aquatic life and biodiversity, impacts on microorganisms possible
Disposal Methods: Handle as hazardous waste, use an approved chemical waste incinerator, follow local, state, and federal hazardous waste regulations
Container Disposal: Triple-rinse and offer clean containers for recyclables, or incinerate empty container if residues remain
Precautions: Avoid release to the environment, keep separated from regular trash collection
Waste Code: EPA hazardous waste number for nitroso compounds may apply; consult local regulations
UN Number: UN 2811 (Toxic solid, organic, n.o.s.)
Transport Class: 6.1 (Toxic substances)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 4-Nitroso-N,N-Dimethylaniline)
Packing Group: II
Labels Required: Toxic, keep away from incompatible substances
Marine Pollutant: Yes, potential risk
Special Precautions: Secure tightly, handle with protective gloves, keep well separated from food and animal feed, provide documentation along with shipment
Labeling: According to GHS and OSHA HCS 2012, toxic and environmentally hazardous
Chemical Inventory Status: Listed in TSCA (US), EINECS (EU), DSL (Canada)
Restrictions: Not approved for food, drug, or cosmetic use
Right-to-Know Information: Listed substances under SARA Title III; subject to reporting in many regions
Workplace Control: Must comply with worker right-to-know and chemical safety implementation rules; chemical hygiene plans and documented risk assessments required
Additional Compliance: Employers obligated to conduct training on handling toxic or suspected carcinogens; annual inventory review recommended
