© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: 4-Nitrophenetole
Chemical Formula: C8H9NO3
CAS Number: 100-17-4
Synonyms: p-Nitrophenetole, 1-Ethoxy-4-nitrobenzene, para-Nitrophenetole
Recommended Use: Laboratory reagent, chemical synthesis intermediate
Supplier Details: Names, addresses, and contact phone numbers for reputable suppliers or chemical safety teams
Emergency Contact: 24-hour emergency phone number for chemical spill or exposure
Hazard Class: Acute Toxicity (oral, dermal, inhalation), Eye Irritation, Skin Irritation
GHS Classification: Acute Tox. 4, Eye Irrit. 2, Skin Irrit. 2
Pictograms: Exclamation mark for irritation, health hazard for organ damage
Signal Word: Warning
Hazard Phrases: Harmful by inhalation, skin contact or ingestion; causes serious eye and skin irritation, possible damage to organs
Precautionary Statements: Avoid breathing dust, use protective equipment, wash hands thoroughly after handling, keep away from food and drink
Chemical Name: 4-Nitrophenetole
Common Name: p-Nitrophenetole
Concentration: Greater than 99% by weight
Impurities: Trace phenetole, other nitroanisoles (less than 0.1%)
Additional Ingredients: No stabilizing additives commonly present
Inhalation: Move person to fresh air immediately, keep warm and still, provide oxygen if breathing becomes difficult, seek medical attention
Skin Contact: Wash area with plenty of water and mild soap, remove contaminated clothing, rinse for at least 15 minutes, call poison control or physician in case of rash or irritation
Eye Contact: Rinse eyes with running water for a minimum of 15 minutes, remove contact lenses if present, keep eyelids open and get prompt ophthalmological evaluation
Ingestion: Rinse mouth with water, do not induce vomiting, never give fluids to someone unconscious, get urgent medical help; monitor breathing and circulation
Most Important Symptoms: Nausea, headache, confusion, dizziness, skin rash, redness or irritation, possible delayed effects from organ toxicity
Notes for Medical Staff: Symptomatic treatment, monitor vital signs, treat as per nitroaromatic poisoning protocols
Suitable Extinguishing Agents: Use carbon dioxide, dry chemical powder, foam, or water spray for small fires; do not use water jet for larger spills as chemical may not be soluble
Specific Hazards Arising: May emit toxic fumes such as nitrogen oxides and carbon monoxide in fire
Firefighter Precautions: Wear self-contained breathing apparatus, chemical-resistant suit, approach from upwind side, avoid inhalation of combustion products
Explosion Data: Not considered highly flammable, dust may form explosive mixture with air at high concentrations
Special Instructions: Cool tanks with water spray, fight fire from safe distance
Personal Protection: Wear safety goggles, gloves, chemical splash apron, and NIOSH-approved respirator
Spill Procedure: Avoid dust formation, ventilate area, evacuate nonessential personnel
Containment: Sweep up with non-sparking tools, moisten spill to avoid dispersal, transfer to closed, labeled containers
Disposal: Place waste in designated chemical hazard containers for approved disposal
Environmental Precautions: Prevent run-off into drains, watercourses, or soil
Safe Handling: Avoid inhalation and contact with eyes, skin, or clothing; operate in fume hood or well-ventilated site; keep away from heat, sparks, ignition sources
Storage Conditions: Store in tightly sealed containers, in a cool, dry, and well-ventilated place, away from direct sunlight and incompatible substances
Incompatibilities: Strong acids, strong bases, reducing agents, oxidizing materials
Hygiene Practices: Wash hands and face thoroughly after handling; remove contaminated clothing and clean before reuse
Other Advice: Implement secondary containment and chemical spill preparedness
Exposure Limits: No OSHA or ACGIH PEL/TLV values established; minimize exposure as much as possible
Engineering Controls: Work inside fume hood, use local exhaust ventilation, maintain eye-wash stations and safety showers
Respiratory Protection: NIOSH-approved respirators for powder or vapor
Eye Protection: Chemical splash goggles, full-face shield if risk of splashing
Skin Protection: Nitrile or neoprene gloves, lab coat, closed-toed shoes; chemical-resistant apron for bulk work
Work Practice Controls: Prohibit eating, drinking, or smoking in work area
Appearance: Light yellow to pale brown solid, crystalline powder
Odor: Slight aromatic, sweetish smell
Melting Point: 53–56 °C
Boiling Point: 305–307 °C
Flash Point: 150 °C
Density: 1.26 g/cm³
Solubility: Slightly soluble in water, readily soluble in ethanol, chloroform, and most organic solvents
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): 2.2–2.5
pH: Not applicable; neutral solid
Chemical Stability: Stable under normal storage and usage conditions
Conditions to Avoid: Excess heat, open flame, strong oxidizing agents, strong acids, bases
Hazardous Decomposition: Decomposes upon heating, releasing toxic gases including nitrogen oxides, carbon oxides
Polymerization: Will not undergo hazardous polymerization
Incompatibility: Strong oxidizers, reducing agents, other nitro compounds
Acute Toxicity: Oral LD50 (rat) approximately 440 mg/kg; skin and eye irritant
Chronic Effects: Possible organ toxicity with prolonged exposure, mainly affects blood and methemoglobin levels
Potential Health Effects: Irritation of mucous membranes, skin, and respiratory tract; headaches, drowsiness, cyanosis, nausea, methemoglobinemia
Sensitization: Not a proven skin or respiratory sensitizer based on existing data
Carcinogenicity: No IARC, NTP, or OSHA listing as carcinogen; insufficient evidence for mutagenicity or reproductive harm
Other Information: Symptoms may be delayed; monitor for methemoglobinemia after exposures
Aquatic Toxicity: Likely toxic to aquatic organisms, low degradability, risk of bioaccumulation
Persistence and Degradability: Degrades slowly, not readily biodegradable
Bioaccumulative Potential: Moderate, with log Kow around 2–2.5
Mobility in Soil: May migrate through soil, moderate risk of groundwater contamination
Other Adverse Effects: Avoid uncontrolled release to surface water, soil or drains
Waste Methods: Do not pour down drain, place in sealed, properly labeled chemical waste containers
Incineration: High-temperature incineration with flue gas scrubbing preferred
Special Instructions: Dispose according to local, regional, and national regulations
Container Disposal: Triple rinse empty containers, puncture, and send to licensed chemical waste treatment facility
UN Number: 2811 (if applicable, for toxic solids, organic, n.o.s.)
UN Shipping Name: Toxic solid, organic, n.o.s. (contains 4-nitrophenetole)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (minor hazard)
Marine Pollutant: Not listed as a marine pollutant
Transport Precautions: Store in well-sealed containers upright, segregate from food or feedstuffs, keep away from incompatible materials
US Federal: Subject to SARA Section 313 reporting for certain uses; not a listed RCRA hazardous waste
OSHA: Considered hazardous under OSHA Hazard Communication Standard
TSCA: Listed in TSCA inventory
Global Inventories: Included in European (EINECS), Canadian (DSL), and Japanese (ENCS) chemical inventories
Labeling Requirements: GHS hazard phrases and pictograms on all containers
Other Statutes: Local, state, and international regulations may apply; always check site-specific requirements before storage, use, or disposal
