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Product Name: 4-Nitrobenzyl Cyanide
Chemical Formula: C8H6N2O2
CAS Number: 619-28-7
Synonyms: p-Nitrobenzyl cyanide, 1-(4-nitrophenyl)acetonitrile
Manufacturer/Supplier: Refer to supplier label
Intended Uses: Laboratory reagent, chemical synthesis intermediate
Emergency Contact: Contact local poison control center or emergency services immediately in case of accidental exposure
Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye irritation, long-term environmental hazard
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, toxic if inhaled, causes skin and eye irritation, may cause respiratory tract irritation
Precautionary Statements: Avoid breathing dust or vapors, wash skin thoroughly after handling, use protective equipment including gloves, goggles and suitable clothing, avoid release to the environment
Symptoms of Exposure: Headache, dizziness, confusion, cyanosis, respiratory distress, nausea, vomiting, eye and skin redness
Potential Environmental Effects: Highly toxic to aquatic organisms, may persist in soil and water
Chemical Identity: 4-Nitrobenzyl Cyanide
Purity: Above 98% (varies by supplier)
Impurities: None known that contribute to hazard
Molecular Weight: 162.15 g/mol
Physical Form: Crystalline powder, pale yellow
Inhalation: Move exposed individual to fresh air, keep relaxed, provide oxygen if breathing is difficult, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse exposed skin with water for at least 20 minutes, do not use solvent, seek medical advice if irritation persists
Eye Contact: Rinse eyes with running water for a minimum of 20 minutes uplifting eyelids occasionally, remove contact lenses if present, seek prompt medical care
Ingestion: Rinse mouth with water, do not induce vomiting, never give anything by mouth to an unconscious person, seek urgent medical attention
Most Important Symptoms and Effects: Cyanosis, respiratory depression, serious irritation
Notes for Medical Provider: Monitor for methemoglobinemia; treat symptomatically
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray (cooling only, do not use water jet directly on chemical)
Hazards from Combustion: Emits toxic gases including hydrogen cyanide, oxides of nitrogen, carbon oxides under fire conditions
Special Protective Actions: Use self-contained breathing apparatus and fully protective clothing
Specific Procedures: Move products from fire area if it is safe to do so, keep containers cool using water spray
Explosion Sensitivity: No known explosive properties under normal handling
Personal Precautions: Evacuate area, wear full protective clothing, control dust formation, avoid inhalation and contact
Environmental Precautions: Prevent run-off into drains, surface or ground waters, notify environmental authorities if larger spill enters waterway
Containment: Use non-sparking tools to minimize static, avoid generating dust, cover spilled material with absorbent material (sand, dry earth), shovel into suitable container
Cleanup Methods: Collect and seal in properly labeled chemical waste container, decontaminate area with soap and water
Decontamination: Ventilate area thoroughly after cleanup
Handling: Use in chemical fume hood with adequate ventilation, avoid dust and vapor formation, avoid contact with skin, eyes and clothing, employ good laboratory practices, wash hands after handling
Storage: Store in tightly closed, corrosion-resistant container in a cool, dry, well-ventilated place away from incompatible substances (strong acids, strong bases, oxidizers and reducing agents), keep out of direct sunlight, segregate from food and animal feed
Occupational Hygiene: Do not eat, drink or smoke near material, store personal protective equipment separately
Exposure Limits: None established by OSHA, ACGIH, or NIOSH for this compound; minimize all exposures
Engineering Controls: Chemical fume hood, local exhaust ventilation, use enclosed processes wherever possible
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, laboratory coat, long sleeves, suitable respirator (approved for toxic dust/vapors) if exposure is likely
Hygiene Practices: Remove contaminated clothing and wash before reuse, maintain eye wash station and safety shower in immediate work area
Appearance: Pale yellow crystalline solid
Odor: Faint, sweetish, not pungent
pH: Not applicable (solid substance)
Melting Point: 106–108°C
Boiling Point: Decomposes before boiling
Flash Point: Not available, expected above 100°C
Evaporation Rate: Not applicable
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: Low (practically nonvolatile at room temperature)
Solubility: Slightly soluble in water, soluble in organic solvents (acetone, ethanol, ether)
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: >200°C
Molecular Formula: C8H6N2O2
Molecular Weight: 162.15 g/mol
Chemical Stability: Stable under recommended storage conditions
Reactivity: Non-reactive with most laboratory materials
Incompatible Materials: Strong acids, bases, oxidizers, reducing agents; avoid moisture and sunlight
Hazardous Decomposition: Emits hazardous gases (hydrogen cyanide, nitrogen oxides) under heating or fire
Polymerization: No dangerous polymerization
Acute Toxicity: Oral, dermal, and inhalation toxicity confirmed in rodents; estimated LD50 (oral, rat) approx. 150 mg/kg
Skin Corrosion/Irritation: Causes redness, inflammation, possible burns with prolonged or repeated exposure
Serious Eye Damage/Irritation: Causes eye irritation and possible injury on contact
Respiratory Effects: Exposure can cause shortness of breath, coughing, cyanosis, in severe cases, risk of respiratory depression
Chronic Effects: Potential for cumulative toxicity not excluded, long-term data lacking
Carcinogenicity/Mutagenicity/Reproductive Effects: No human data, no IARC, NTP or OSHA listing
Sensitization: Not documented in published literature
Additional Information: Symptoms of exposure can be delayed, serious effects require immediate attention
Ecotoxicity: Highly toxic to aquatic life, may cause long lasting adverse effects in aquatic environments, avoid contamination of water bodies
Persistence and Degradability: Not readily biodegradable, likely to persist in soil and surface waters
Bioaccumulation Potential: May bioaccumulate; log Kow not available, similar substances show moderate-to-high bioconcentration factors
Mobility in Soil: Moderately mobile if released; risk of contamination of groundwater cannot be excluded
Other Adverse Effects: Potential impacts on soil bacteria and invertebrates
Waste Disposal Recommendations: Handle as hazardous chemical waste, store in sealed, properly labeled containers, dispose at licensed hazardous waste facility
Contaminated Packaging: Rinse thoroughly, dispose as hazardous chemical waste, do not reuse containers
Disposal Must Follow: All local, regional, and national regulations; open burning or landfill disposal not appropriate
Do Not Release: Do not pour into drains, soil, or aquatic environment
UN Number: Not classified under major shipping codes, consult transport authority for hazard class
Shipment Name: Consult with supplier, may be shipped as “toxic solid, organic, n.o.s.” depending on jurisdiction
Hazard Class: 6.1 (Toxic substances, if classified)
Packing Group: II or III depending on quantity and jurisdiction
Environmental Hazards: Marine pollutant according to international guidelines
Transport Precautions: Ship in tightly sealed packaging, keep segregated from incompatible materials, do not transport with food or feedstuffs, emergency response guide available from supplier
US Regulations: Not listed specifically under SARA Title III; regulated as a hazardous substance under OSHA and EPA for acute toxicity
TSCA: Listed in the Toxic Substances Control Act Inventory
EU Regulations: REACH registered or pre-registered, classified as hazardous per CLP/GHS
International Inventories: Listed in EINECS (EC Number: 210-604-0), included in Japanese ENCS and other chemical inventories
Labeling: Must display hazard pictograms, signal word Danger, and relevant hazard/precautionary statements
Other: Lab use only unless specific permission for wider use; notify authorities if spilled in significant quantity
